Reactome | MTNR1A [plasma membrane]

MTNR1A [plasma membrane]

Stable Identifier

R-HSA-419316

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Melatonin receptor type 1A, MTR1A_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Melatonin receptors can bind melatonin (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48039 MTNR1A

Gene Names

MTNR1A

Chain

chain:1-350

Reference Genes

BioGPS Gene:4543 MTNR1A

COSMIC (genes):MTNR1A MTNR1A

CTD Gene:4543 MTNR1A

dbSNP Gene:4543 MTNR1A

ENSEMBL:ENSG00000168412 MTNR1A

ENSEMBL_homo_sapiens_GENE:ENSG00000168412.7 MTNR1A

HGNC:7463 MTNR1A

KEGG Gene (Homo sapiens):4543 MTNR1A

Monarch:4543 MTNR1A

NCBI Gene:4543 MTNR1A

OMIM:600665 MTNR1A

UCSC:P48039 MTNR1A

Reference Transcript

RefSeq:NM_005958.4 MTNR1A

Other Identifiers

11715262_at

16982264

221369_PM_at

221369_at

2797355

2797356

2797357

2797358

2797359

2797360

2797377

2797378

4543

8104074

ADDON002880.hg

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007193

GO:0007617

GO:0007623

GO:0008502

GO:0016020

GO:0022414

GO:0023052

GO:0042562

GO:0043235

GO:0060089

GO:0097159

HMNXSV003038319

ILMN_1708845

PH_hs_0013167

TC04002950.hg

g5174592_3p_at

Participates

as a member of

Melatonin receptors [plasma membrane] (Homo sapiens)

Inferred To

moody [plasma membrane] (Drosophila melanogaster)

mtnr1aa [plasma membrane] (Danio rerio)

MTNR1A [plasma membrane] (Bos taurus)

MTNR1A [plasma membrane] (Canis familiaris)

MTNR1A [plasma membrane] (Gallus gallus)

MTNR1A [plasma membrane] (Sus scrofa)

npr-25 [plasma membrane] (Caenorhabditis elegans)

Mtnr1a [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_005949.1

ZINC - World Drugs

MTR1A_HUMAN

Guide to Pharmacology - Targets

287

OpenTargets

ENSG00000168412

ZINC - FDA approved

MTR1A_HUMAN

ZINC - Substances

MTR1A_HUMAN

ZINC target

P48039

ZINC - Biogenic

MTR1A_HUMAN

PRO

P48039

PDB

7DB6, 6ME3, 7VGZ, 6ME5, 6ME2, 7VGY, 6ME4

ZINC - Investigational

MTR1A_HUMAN

ZINC - Metabolites

MTR1A_HUMAN

HPA

ENSG00000168412-MTNR1A

GeneCards

P48039

Ensembl

ENSP00000302811, ENST00000307161, ENSP00000515216, ENSG00000168412, ENST00000703170

Pharos - Targets

P48039

Orphanet

26875

ZINC - Predictions - Purchasable

MTR1A_HUMAN

HMDB Protein

HMDBP10872

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.659	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.527	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.527	2