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DCT [melanosome membrane]
Stable Identifier
R-HSA-5662685
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
melanosome membrane
Synonyms
L-dopachrome tautomerase, TYRP2_HUMAN, TRP2, Tyrosinase-related protein 2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M-dependent DCT gene expression (Homo sapiens)
DCT [melanosome membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Melanin biosynthesis (Homo sapiens)
Dopachrome is transformed to DHICA by DCT (Homo sapiens)
DCT:2xZn2+ [melanosome membrane] (Homo sapiens)
DCT [melanosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40126 DCT
Gene Names
DCT, TYRP2
Chain
signal peptide:1-23, chain:24-519
Reference Genes
BioGPS Gene:1638 DCT
COSMIC (genes):DCT DCT
CTD Gene:1638 DCT
dbSNP Gene:1638 DCT
ENSEMBL:ENSG00000080166 DCT
HGNC:2709 DCT
KEGG:hsa:1638 DCT
Monarch:1638 DCT
NCBI Gene:1638 DCT
OMIM:191275 DCT
UCSC:P40126 DCT
Reference Transcript
RefSeq:NM_001129889.2 DCT
RefSeq:NM_001922.4 DCT
Other Identifiers
11729446_a_at
11758553_s_at
11759082_at
1638
16780208
16780227
205337_PM_at
205337_at
205338_PM_s_at
205338_s_at
216512_PM_s_at
216512_s_at
216513_PM_at
216513_at
31464_at
31465_g_at
3520935
3520936
3520937
3520938
3520939
3520940
3520943
3520944
3520945
3520947
3520948
3520950
3520951
3520952
3520953
3520954
3520955
3520956
3520957
3520958
3520959
3520962
3520963
3520964
41182_at
48466_at
60487_at
7972259
A_23_P76622
A_24_P390150
A_24_P68381
D17547_at
GE80616
GO:0002052
GO:0003824
GO:0004167
GO:0005507
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006520
GO:0006583
GO:0007405
GO:0008544
GO:0009637
GO:0016020
GO:0016491
GO:0016853
GO:0021847
GO:0031410
GO:0033162
GO:0042438
GO:0042470
GO:0043226
GO:0043231
GO:0043473
GO:0046872
GO:0048066
GO:0048468
GO:0048856
HMNXSV003014998
Hs.301865.0.S2_3p_at
Hs.301865.1.S1_3p_a_at
ILMN_1701783
PH_hs_0015572
PH_hs_0039476
S69231_s_at
TC13000790.hg
TC13000791.hg
TC13001632.hg
g6041666_3p_a_at
Participates
as an output of
MITF-M-dependent DCT gene expression (Homo sapiens)
as a component of
DCT:2xZn2+ [melanosome membrane] (Homo sapiens)
Inferred To
dct [melanosome membrane]
(Danio rerio)
dct [melanosome membrane]
(Xenopus tropicalis)
tyr-2 [melanosome membrane]
(Caenorhabditis elegans)
tyr-5 [melanosome membrane]
(Caenorhabditis elegans)
tyr-4 [melanosome membrane]
(Caenorhabditis elegans)
Dct [melanosome membrane]
(Rattus norvegicus)
DCT [melanosome membrane]
(Bos taurus)
DCT [melanosome membrane]
(Caenorhabditis elegans)
DCT [melanosome membrane]
(Canis familiaris)
DCT [melanosome membrane]
(Dictyostelium discoideum)
DCT [melanosome membrane]
(Gallus gallus)
DCT [melanosome membrane]
(Mus musculus)
DCT [melanosome membrane]
(Sus scrofa)
tyr-6 [melanosome membrane]
(Caenorhabditis elegans)
Homologues of DCT [melanosome membrane]
(Caenorhabditis elegans)
Homologues of DCT [melanosome membrane]
(Dictyostelium discoideum)
Cross References
ENSEMBL
ENST00000446125
,
ENST00000377028
,
ENSP00000392762
,
ENSP00000366227
OpenTargets
ENSG00000080166
HPA
ENSG00000080166-DCT
PRO
P40126
Pharos - Targets
P40126
GlyGen
P40126
HMDB Protein
HMDBP00209
PDB
4HX1
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60201-2 PLP1
0.556
3
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.527
3
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