Reactome | LBR [nuclear envelope]

LBR [nuclear envelope]

Stable Identifier

R-HSA-194637

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

Lamin-B receptor

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        CDK1 phosphorylates LBR (Homo sapiens)
        
        LBR [nuclear envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14739 LBR

Gene Names

LBR

Chain

chain:1-615

Reference Genes

BioGPS Gene:3930 LBR

COSMIC (genes):LBR LBR

CTD Gene:3930 LBR

dbSNP Gene:3930 LBR

ENSEMBL:ENSG00000143815 LBR

HGNC:6518 LBR

KEGG:hsa:3930 LBR

Monarch:3930 LBR

NCBI Gene:3930 LBR

OMIM:600024 LBR

UCSC:Q14739 LBR

Reference Transcript

Other Identifiers

11716797_s_at

11751573_a_at

16699877

201795_PM_at

201795_at

2458290

2458291

2458292

2458293

2458295

2458296

2458298

2458299

2458301

2458303

2458304

2458305

2458306

2458310

2458311

2458312

2458313

2458314

2458315

2458316

2458320

2458321

2458322

288_s_at

3930

7924603

A_23_P200493

GE57697

GO:0003677

GO:0003723

GO:0003824

GO:0005515

GO:0005521

GO:0005634

GO:0005635

GO:0005637

GO:0005652

GO:0005737

GO:0005783

GO:0005789

GO:0006325

GO:0006629

GO:0006695

GO:0016020

GO:0016126

GO:0016491

GO:0016628

GO:0030154

GO:0030223

GO:0031965

GO:0043226

GO:0050613

GO:0060090

GO:0060816

GO:0070087

GO:0070402

GO:0140463

HMNXSV003005095

ILMN_1768969

ILMN_1810418

ILMN_2285480

L25931_s_at

PH_hs_0030224

TC01003887.hg

g4504960_3p_at

Participates

as a component of

MECP2:LBR [nuclear envelope] (Homo sapiens)

as an input of

Other forms of this molecule

p-S71,S86-LBR [nuclear envelope]

LBR [endoplasmic reticulum membrane]

LBR [endosome membrane]

Inferred To

LBR [nuclear envelope] (Bos taurus)

LBR [nuclear envelope] (Canis familiaris)

LBR [nuclear envelope] (Dictyostelium discoideum)

LBR [nuclear envelope] (Gallus gallus)

LBR [nuclear envelope] (Saccharomyces cerevisiae)

LBR [nuclear envelope] (Schizosaccharomyces pombe)

LBR [nuclear envelope] (Sus scrofa)

lbr [nuclear envelope] (Danio rerio)

lbr [nuclear envelope] (Xenopus tropicalis)

Lbr [nuclear envelope] (Mus musculus)

Lbr [nuclear envelope] (Rattus norvegicus)

Cross References

RefSeq

NP_002287.2, NP_919424.1, XP_011542487.1

OpenTargets

ENSG00000143815

ENSEMBL

ENST00000338179, ENSP00000339883, ENST00000272163, ENSP00000272163

HPA

ENSG00000143815-LBR

PRO

Q14739

Pharos - Targets

Q14739

Orphanet

LBR

GlyGen

Q14739

PDB

2DIG

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.749	5
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.617	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	4
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.605	4
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.564	2
UniProt:Q07021 C1QBP	3	C1QBP [plasma membrane] (R-HSA-158123) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [cytosol] (R-HSA-9645690)	0.564	2
UniProt:Q8NAF0 ZN579			0.564	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q15013 MD2BP			0.527	2
UniProt:Q7RTS1 BHLHA15	1	BHLHA15 [nucleoplasm] (R-HSA-9922593)	0.527	4
UniProt:P49761 CLK3			0.527	2
UniProt:O75596 CLC3A			0.527	2