Reactome | AGT(34-43) [extracellular region]

AGT(34-43) [extracellular region]

Stable Identifier

R-HSA-2022346

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Angiotensin-(1-10), Angiotensin I, Angiotensin-1, ANGT_HUMAN, AGT, ANG1-10

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External Reference Information

External Reference

UniProt:P01019 AGT

Gene Names

AGT, SERPINA8

Chain

signal peptide:1-24, chain:25-476, peptide:25-34, peptide:25-33, peptide:25-32, peptide:25-31, peptide:25-29, peptide:25-28, peptide:26-32, peptide:27-32

Reference Genes

BioGPS Gene:183 AGT

COSMIC (genes):AGT AGT

CTD Gene:183 AGT

dbSNP Gene:183 AGT

ENSEMBL:ENSG00000135744 AGT

HGNC:333 AGT

Monarch:183 AGT

NCBI Gene:183 AGT

OMIM:106150 AGT

UCSC:P01019 AGT

Reference Transcript

RefSeq:NM_000029.3 AGT

Participates

as an input of

as an output of

Other forms of this molecule

AGT(34-41) [extracellular region]

AGT [extracellular region]

AGT(34-42) [extracellular region]

AGT(34-40) [extracellular region]

AGT(35-41) [extracellular region]

AGT(36-41) [extracellular region]

Inferred To

AGT(34-43) [extracellular region] (Caenorhabditis elegans)

AGT(34-43) [extracellular region] (Gallus gallus)

Spn42Da [extracellular region] (Drosophila melanogaster)

Agt [extracellular region] (Mus musculus)

Agt [extracellular region] (Rattus norvegicus)

srp-6 [extracellular region] (Caenorhabditis elegans)

Spn28Da [extracellular region] (Drosophila melanogaster)

AGT [extracellular region] (Bos taurus)

AGT [extracellular region] (Canis familiaris)

AGT [extracellular region] (Sus scrofa)

Spn88Eb [extracellular region] (Drosophila melanogaster)

Spn27A [extracellular region] (Drosophila melanogaster)

srp-2 [extracellular region] (Caenorhabditis elegans)

Acp76A [extracellular region] (Drosophila melanogaster)

Spn100A [extracellular region] (Drosophila melanogaster)

Spn42Dd [extracellular region] (Drosophila melanogaster)

srp-8 [extracellular region] (Caenorhabditis elegans)

Spn43Aa [extracellular region] (Drosophila melanogaster)

Spn47C [extracellular region] (Drosophila melanogaster)

Dmel\CG43366 [extracellular region] (Drosophila melanogaster)

srp-7 [extracellular region] (Caenorhabditis elegans)

Spn42Db [extracellular region] (Drosophila melanogaster)

Spn75F [extracellular region] (Drosophila melanogaster)

Spn28Db [extracellular region] (Drosophila melanogaster)

Spn55B [extracellular region] (Drosophila melanogaster)

nec [extracellular region] (Drosophila melanogaster)

Spn31A [extracellular region] (Drosophila melanogaster)

Spn43Ab [extracellular region] (Drosophila melanogaster)

Spn53F [extracellular region] (Drosophila melanogaster)

Spn88Ea [extracellular region] (Drosophila melanogaster)

Homologues of AGT(34-43) [extracellular region] (Caenorhabditis elegans)

Homologues of AGT(34-43) [extracellular region] (Drosophila melanogaster)

srp-1 [extracellular region] (Caenorhabditis elegans)

Spn38F [extracellular region] (Drosophila melanogaster)

agt [extracellular region] (Danio rerio)

agt [extracellular region] (Xenopus tropicalis)

srp-3 [extracellular region] (Caenorhabditis elegans)

Spn42Dc [extracellular region] (Drosophila melanogaster)

Spn42De [extracellular region] (Drosophila melanogaster)

Spn28B [extracellular region] (Drosophila melanogaster)

Spn85F [extracellular region] (Drosophila melanogaster)

Spn28F [extracellular region] (Drosophila melanogaster)

Spn43Ad [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_000020.1

OpenTargets

ENSG00000135744

ENSEMBL

ENST00000680041, ENSP00000505985, ENSP00000505963, ENSP00000355627, ENST00000681269, ENSG00000135744, ENSP00000505063, ENST00000681514, ENST00000366667, ENST00000679738, ENSP00000504866

HPA

ENSG00000135744-AGT

GeneCards

AGT

PRO

P01019

Pharos - Targets

P01019

GlyGen

P01019

Orphanet

AGT

HMDB Protein

HMDBP02609

PDB

1N9U, 5M3Y, 4AA1, 5E2Q, 4FYS, 2JP8, 3WOO, 6I3I, 2WXW, 5XJM, 3WOR, 4APH, 6JOD, 2X0B, 3CK0, 6I3F, 5M3X, 6OS0, 7C6A, 1N9V

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00797 REN	3	REN [extracellular region] (R-HSA-2022343) REN(24-406) [plasma membrane] (R-HSA-2065391) REN [plasma membrane] (R-HSA-2022352)	0.558	2
UniProt:Q10714	2	ACE(30-1232) [extracellular region] (R-DME-2065414-2) ACE(30-1306) [plasma membrane] (R-DME-508496-2)	0.558	2
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:Q8TAS3 Q8TAS3			0.556	3
UniProt:Q8NFB2 T185A			0.556	3
UniProt:CCDC26 A0A024R9H7			0.556	3
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:C9J082 C9J082			0.556	3
UniProt:O43493-5 O434935			0.556	3
UniProt:Q9UI10 EIF2B4	1	EIF2B4 [cytosol] (R-HSA-72521)	0.556	3
UniProt:Q9UMY4 SNX12			0.556	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.527	2
UniProt:O95167 NDUFA3	1	NDUFA3 [mitochondrial inner membrane] (R-HSA-60180)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2

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