CANX dissociates from IL12A:EBI3

Stable Identifier
Reaction [omitted]
Homo sapiens
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Interleukin-12 subunit alpha (IL12A, IL12p35) binds Interleukin-27 subunit beta (EBI3) forming the Interleukin-35 heterodimeric complex (IL12A:EBI3)(Devergne et al.). When expressed alone, human EBI3 is associated with the endoplasmic reticulum (ER) resident molecular chaperone calnexin (CANX) and is retained in the ER (Devergne et al. 1997). Co-expression of IL27 and EBI3 enables formation of IL27:EBI3, allowing secretion (Pflanz et al. 2002).

This is a Black Box event because there is not reported wich reaction occurs first: the association of IL12A to EBI3:CANX and later the Interleukin-35 heterodimeric protein formation.

Literature References
PubMed ID Title Journal Year
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Vaisberg, E, Gorman, DM, Timans, JC, Gilbert, J, Mattson, JD, Hibbert, L, Travis, M, Rennick, D, To, W, Kastelein, RA, Kanzler, H, Zurawski, S, Cheung, J, Rosales, R, Pflanz, S, Wagner, JL, Blumenschein, WM, Bazan, JF, de Waal Malefyt, R, Churakova, T, McClanahan, TK

Immunity 2002
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Birkenbach, M, Devergne, O, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
Orthologous Events
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