Reactome | PON2 [extracellular region]

PON2 [extracellular region]

Stable Identifier

R-HSA-8932636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Serum paraoxonase/arylesterase 2, PON2_HUMAN

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonic acid metabolism (Homo sapiens)
      - Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
        
        PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)
        
        PON1,2,3:2xCa2+ dimers [extracellular region] (Homo sapiens)
        
        PON2:2xCa2+ dimer [extracellular region] (Homo sapiens)
        
        PON2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15165 PON2

Gene Names

PON2

Chain

chain:1-354, signal peptide:1-

Reference Genes

BioGPS Gene:5445 PON2

COSMIC (genes):PON2 PON2

CTD Gene:5445 PON2

dbSNP Gene:5445 PON2

ENSEMBL:ENSG00000105854 PON2

ENSEMBL_homo_sapiens_GENE:ENSG00000105854.13 PON2

HGNC:9205 PON2

KEGG Gene (Homo sapiens):5445 PON2

Monarch:5445 PON2

NCBI Gene:5445 PON2

OMIM:602447 PON2

UCSC:Q15165 PON2

Reference Transcript

Other Identifiers

11737479_a_at

11737480_x_at

11741354_a_at

17059932

201876_PM_at

201876_at

210830_PM_s_at

210830_s_at

3061998

3061999

3062000

3062001

3062003

3062006

3062012

3062013

3062017

3062018

3062020

3062021

3062022

3062028

3062033

3062040

3062041

3062042

40504_at

5445

8141076

A_23_P31399

GE54041

GO:0003824

GO:0004064

GO:0005576

GO:0005886

GO:0009636

GO:0016020

GO:0016787

GO:0019439

GO:0042802

GO:0046872

GO:0102007

HMNXSV003006756

ILMN_1714158

ILMN_2354381

L48513_at

PH_hs_0022782

PH_hs_0031950

TC07001617.hg

TC07003069.hg

g2228776_3p_a_at

g4505952_3p_at

Participates

as a component of

PON2:2xCa2+ dimer [extracellular region] (Homo sapiens)

Inferred To

PON2 [extracellular region] (Bos taurus)

PON2 [extracellular region] (Caenorhabditis elegans)

PON2 [extracellular region] (Canis familiaris)

PON2 [extracellular region] (Danio rerio)

PON2 [extracellular region] (Gallus gallus)

PON2 [extracellular region] (Mus musculus)

PON2 [extracellular region] (Rattus norvegicus)

PON2 [extracellular region] (Sus scrofa)

PON2 [extracellular region] (Xenopus tropicalis)

Homologues of PON2 [extracellular region] (Caenorhabditis elegans)

Homologues of PON2 [extracellular region] (Danio rerio)

poml-3 [extracellular region] (Caenorhabditis elegans)

mec-6 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001018171.1, NP_000296.2

Guide to Pharmacology - Targets

3053

OpenTargets

ENSG00000105854

GeneCards

Q15165

HPA

ENSG00000105854-PON2

Ensembl

ENST00000222572, ENSG00000105854, ENST00000433091, ENSP00000404622, ENSP00000488838, ENSP00000222572, ENST00000633531

PRO

Q15165

Pharos - Targets

Q15165

Orphanet

19321

HMDB Protein

HMDBP00092

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.499	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439)	0.462	2

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