Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
N4GlycoAsn-PalmS WNT3A
Stable Identifier
R-HSA-3247784
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
N4GlycoAsn-O-palmitoleyl-L-serine-WNT3A, palmitoleyl-N-glycosyl WNT3A, palmitoleoyl-N-glycosyl WNT3A
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
RNF mutants show enhanced WNT signaling and proliferation (Homo sapiens)
RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)
RYK-binding WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
RYK:WNTs [plasma membrane] (Homo sapiens)
RYK-binding WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
FZD recruits DVL to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (Homo sapiens)
WIF1 binds WNTs (Homo sapiens)
WIF1-binding WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WIF1:WNT [extracellular region] (Homo sapiens)
WIF1-binding WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT3A:sFRP [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
WIF1:WNT [extracellular region] (Homo sapiens)
WIF1-binding WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT3A:sFRP [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
WNT ligand biogenesis and trafficking (Homo sapiens)
secretion of WNT ligands (Homo sapiens)
WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56704 WNT3A
Gene Names
WNT3A
Chain
signal peptide:1-18, chain:19-352
Reference Genes
BioGPS Gene:89780 WNT3A
COSMIC (genes):WNT3A WNT3A
CTD Gene:89780 WNT3A
dbSNP Gene:89780 WNT3A
ENSEMBL:ENSG00000154342 WNT3A
HGNC:15983 WNT3A
KEGG Gene (Homo sapiens):hsa:89780 WNT3A
Monarch:89780 WNT3A
NCBI Gene:89780 WNT3A
OMIM:606359 WNT3A
UCSC:P56704 WNT3A
Reference Transcript
RefSeq:NM_033131.3 WNT3A
Other Identifiers
0003140358
11734990_at
11734991_a_at
11745684_a_at
16678295
2383708
2383709
2383715
2383721
2383724
2383725
66281
7910217
89780
A_14_P122078
A_23_P385690
A_33_P3417502
CCDS1564
ENSG00000154342
ENSP00000284523
ENST00000284523
EntrezGene:89780
GE507271
GO:0001649
GO:0001701
GO:0001756
GO:0001819
GO:0001934
GO:0001947
GO:0002092
GO:0003136
GO:0003713
GO:0005102
GO:0005109
GO:0005110
GO:0005515
GO:0005576
GO:0005578
GO:0005615
GO:0005788
GO:0005796
GO:0005886
GO:0007275
GO:0007368
GO:0007409
GO:0007411
GO:0007498
GO:0008284
GO:0009952
GO:0009986
GO:0010387
GO:0010469
GO:0010628
GO:0010977
GO:0016055
GO:0019904
GO:0021527
GO:0021766
GO:0021846
GO:0021874
GO:0021904
GO:0022008
GO:0030097
GO:0030168
GO:0030182
GO:0030198
GO:0030666
GO:0030879
GO:0030890
GO:0030901
GO:0031901
GO:0032092
GO:0033138
GO:0033278
GO:0034613
GO:0035413
GO:0035914
GO:0036342
GO:0036465
GO:0039706
GO:0042472
GO:0043280
GO:0045595
GO:0045599
GO:0045860
GO:0045893
GO:0045944
GO:0048018
GO:0048103
GO:0048337
GO:0048343
GO:0048643
GO:0048697
GO:0048843
GO:0050768
GO:0050770
GO:0051091
GO:0060021
GO:0060070
GO:0060923
GO:0061098
GO:0061184
GO:0061317
GO:0070062
GO:0070507
GO:0070527
GO:0071300
GO:0090245
GO:0090263
GO:0090676
GO:0098793
GO:0099054
GO:1901215
GO:1903078
GO:1904339
GO:1904798
GO:1904886
GO:1904953
GO:1990851
GO:2000049
GO:2000081
GO:2000179
GO:2000347
GO:2000727
GO:2001141
HGNC:15983
HPA066281
Hs.336930
ILMN_1815700
MIM:606359
NM_033131
NP_149122
PF00110
PH_hs_0016549
PR01349
PR01843
SM00097
TC01001883.hg
uc001hrq.3
UPI000004F0E2
WNT3A
WNT3A-201
XM_011544319
XP_011542621
Participant Of
input
sFRP binds WNT3A and inhibits WNT:FZD binding
hasMember
canonical WNTs [extracellular region]
RYK-binding WNTs [extracellular region]
WIF1-binding WNTs [extracellular region]
WNTs [extracellular region]
hasComponent
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane]
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane]
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane]
WNT3A:sFRP [extracellular region]
Other forms of this molecule
WNT3A [extracellular region]
N4GlycoAsn-PalmS WNT3A [extracellular exosome]
N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane]
N4GlycoAsn-PalmS WNT3A [early endosome membrane]
WNT3A [endoplasmic reticulum lumen]
N4GlycoAsn-WNT3A [endoplasmic reticulum lumen]
N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen]
N4GlycoAsn-PalmS WNT3A [Golgi lumen]
N4GlycoAsn-PalmS WNT3A [plasma membrane]
Inferred To
Homologues of N4GlycoAsn-PalmS WNT3A [extracellular region] (Danio rerio)
Homologues of N4GlycoAsn-PalmS WNT3A [extracellular region] (Sus scrofa)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Bos taurus)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Canis familiaris)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Danio rerio)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Gallus gallus)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Mus musculus)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Rattus norvegicus)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Sus scrofa)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Taeniopygia guttata)
N4GlycoAsn-PalmS WNT3A [extracellular region] (Xenopus tropicalis)
Modified Residues
Name
O-palmitoleyl-L-serine at 209
Coordinate
209
PsiMod Name
O-palmitoleyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.
Name
N4-glycosyl-L-asparagine at unknown position
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Cross References
RefSeq
NP_149122.1
ZINC - Substances
WNT3A_HUMAN
GeneCards
P56704
ZINC target
P56704
PRO
P56704
ZINC - Predictions - Purchasable
WNT3A_HUMAN
Orphanet
21408
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75581 LRP6
8
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
LRP6 [early endosome membrane]
(R-HSA-5368481)
LRP6N [extracellular region]
(R-HSA-5334021)
LRP6 [plasma membrane]
(R-HSA-206252)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
0.609
2
UniProt:Q8J025 APCD1
0.524
3
UniProt:Q9H461 FZD8
2
FZD8 [plasma membrane]
(R-HSA-443947)
ub-FZD8 [plasma membrane]
(R-HSA-4641183)
0.499
2
© 2018
Reactome