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ECE1 [plasma membrane]
Stable Identifier
R-HSA-8876866
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Endothelin-converting enzyme 1, ECE1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
ECE1 cleaves EDN1(53-90) (Homo sapiens)
ECE1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42892 ECE1
Gene Names
ECE1
Chain
chain:1-770
Reference Genes
BioGPS Gene:1889 ECE1
COSMIC (genes):ECE1 ECE1
CTD Gene:1889 ECE1
dbSNP Gene:1889 ECE1
ENSEMBL:ENSG00000117298 ECE1
HGNC:3146 ECE1
KEGG:hsa:1889 ECE1
Monarch:1889 ECE1
NCBI Gene:1889 ECE1
OMIM:600423 ECE1
UCSC:P42892 ECE1
Reference Transcript
RefSeq:XM_011540873.2 ECE1
RefSeq:NM_001113348.1 ECE1
RefSeq:XM_006710398.2 ECE1
RefSeq:NM_001113347.1 ECE1
RefSeq:NM_001113349.1 ECE1
RefSeq:XM_017000511.1 ECE1
RefSeq:NM_001397.2 ECE1
Other Identifiers
11716255_a_at
11716256_x_at
11737800_a_at
11737801_a_at
11739461_a_at
16682989
1889
201749_PM_at
201749_at
201750_PM_s_at
201750_s_at
2400521
2400522
2400523
2400524
2400525
2400526
2400528
2400529
2400530
2400531
2400533
2400534
2400535
2400538
2400539
2400541
2400542
2400548
2400549
2400552
2400553
2400555
2400556
2400557
2400566
2400569
2400570
2400571
2400573
2400574
2400575
2400576
2400577
2400590
2400591
41726_at
45721_at
7913357
A_24_P154080
A_24_P396375
GE60399
GE84643
GO:0001921
GO:0003013
GO:0003100
GO:0003824
GO:0004175
GO:0004222
GO:0005515
GO:0005765
GO:0005768
GO:0005769
GO:0005886
GO:0006508
GO:0007186
GO:0007411
GO:0007507
GO:0008237
GO:0008270
GO:0009897
GO:0010008
GO:0010467
GO:0010814
GO:0010815
GO:0010816
GO:0016020
GO:0016485
GO:0016486
GO:0016787
GO:0017046
GO:0019229
GO:0031175
GO:0031410
GO:0031982
GO:0033093
GO:0034959
GO:0035050
GO:0042447
GO:0042733
GO:0042803
GO:0043226
GO:0043583
GO:0046872
GO:0048471
GO:0048856
GO:0050886
GO:0051604
GO:0060037
GO:0060385
GO:0070062
GO:0097492
GO:0140096
GO:1902287
HMNXSV003022660
Hs.288203.0.S2_3p_at
ILMN_1672174
PH_hs_0023166
TC01002322.hg
TC01005311.hg
Z35307_at
g4503442_3p_a_at
Inferred To
ECE-1 [plasma membrane]
(Gallus gallus)
ECE1 [plasma membrane]
(Bos taurus)
ECE1 [plasma membrane]
(Canis familiaris)
ECE1 [plasma membrane]
(Mus musculus)
ECE1 [plasma membrane]
(Rattus norvegicus)
ECE1 [plasma membrane]
(Sus scrofa)
ece1 [plasma membrane]
(Danio rerio)
ece1 [plasma membrane]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
1615
OpenTargets
ENSG00000117298
ENSEMBL
ENSP00000405088
,
ENSP00000364028
,
ENSP00000264205
,
ENSP00000349581
,
ENST00000374893
,
ENST00000357071
,
ENST00000415912
,
ENST00000264205
ZINC - Substances
ECE1_HUMAN
ZINC - Biogenic
ECE1_HUMAN
ZINC target
P42892
PRO
P42892
GlyGen
P42892
PDB
3DWB
ZINC - Metabolites
ECE1_HUMAN
HPA
ENSG00000117298-ECE1
Pharos - Targets
P42892
ZINC - Predictions - Purchasable
ECE1_HUMAN
Orphanet
ECE1
HMDB Protein
HMDBP12656
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49760 CLK2
0.718
6
UniProt:P60370 KRTAP10-5
1
KRTAP10-5 [cytosol]
(R-HSA-6810260)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
IntAct:EBI-10173330 386677
0.556
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.527
2
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