Reactome | NRAS [plasma membrane]

NRAS [plasma membrane]

Stable Identifier

R-HSA-62725

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p21/N-Ras, Transforming protein N-Ras

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01111 NRAS

Gene Names

NRAS, HRAS1

Chain

chain:1-186, propeptide:187-189

Reference Genes

BioGPS Gene:4893 NRAS

COSMIC - genes:NRAS NRAS

CTD Gene:4893 NRAS

dbSNP Gene:4893 NRAS

ENSEMBL:ENSG00000213281 NRAS

HGNC:7989 NRAS

KEGG:hsa:4893 NRAS

Monarch:4893 NRAS

NCBI Gene:4893 NRAS

OMIM:164790 NRAS

UCSC:P01111 NRAS

Reference Transcript

RefSeq:NM_002524.5 NRAS

Other Identifiers

11719188_at

11719189_at

1539_at

16691262

202647_PM_s_at

202647_s_at

224985_PM_at

224985_at

2429260

2429262

2429263

2429264

2429265

2429266

2429267

2429268

2429270

2429271

4893

7918813

A_23_P63190

A_33_P3317825

GE79523

GO:0000139

GO:0000165

GO:0000166

GO:0001938

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005789

GO:0005794

GO:0005829

GO:0005886

GO:0007165

GO:0007265

GO:0016020

GO:0016787

GO:0019003

GO:0044877

GO:0070062

GO:0070821

GO:0098772

HMNXSV003016401

Hs.260523.1.A1_3p_at

ILMN_1775759

PH_hs_0013620

TC01003014.hg

X02751_at

g6006027_3p_a_at

Participates

as a member of

Other forms of this molecule

S-Farn-Me PalmS NRAS [plasma membrane]

S-Farn NRAS [endoplasmic reticulum membrane]

S-Farn-Me NRAS [endoplasmic reticulum membrane]

S-Farn-proNRAS [endoplasmic reticulum membrane]

proNRAS [cytosol]

S-Farn-Me PalmS NRAS [Golgi membrane]

S-Farn-Me NRAS [plasma membrane]

NRAS Q60E [plasma membrane]

NRAS G12D [plasma membrane]

NRAS G12S [plasma membrane]

NRAS G13D [plasma membrane]

NRAS Q61K [plasma membrane]

NRAS Q61L [plasma membrane]

NRAS Q61R [plasma membrane]

NRAS Q61P [plasma membrane]

NRAS G12A [plasma membrane]

NRAS G12R [plasma membrane]

NRAS G12C [plasma membrane]

NRAS G12V [plasma membrane]

NRAS G13C [plasma membrane]

NRAS G13V [plasma membrane]

NRAS G13R [plasma membrane]

NRAS Q61H [plasma membrane]

NRAS [tertiary granule membrane]

Inferred To

RAS85D [plasma membrane] (Drosophila melanogaster)

rsmA [plasma membrane] (Dictyostelium discoideum)

Homologues of NRAS [plasma membrane] (Dictyostelium discoideum)

Nras [plasma membrane] (Mus musculus)

rsmB [plasma membrane] (Dictyostelium discoideum)

HRAS [plasma membrane] (Caenorhabditis elegans)

NRAS [plasma membrane] (Bos taurus)

NRAS [plasma membrane] (Canis familiaris)

NRAS [plasma membrane] (Danio rerio)

NRAS [plasma membrane] (Dictyostelium discoideum)

NRAS [plasma membrane] (Gallus gallus)

NRAS [plasma membrane] (Rattus norvegicus)

NRAS [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2823

OpenTargets

ENSG00000213281

ENSEMBL

ENSP00000358548, ENST00000369535, ENSG00000213281

ZINC - Substances

RASN_HUMAN

ZINC target

P01111

PRO

P01111

GlyGen

P01111

PDB

6ZIZ, 3CON, 5UHV, 9BGD, 6ZIR, 6ZIO, 6ULK, 6MPP, 6ULI, 8VM2, 8TBI, 6E6H, 6ULN, 9BG3, 9BTM, 6UON, 6WGH, 2N9C, 9BG8, 7OW3, 7OW5, 7OW6, 7OW4, 7PB2, 9BG0, 6ULR, 7F68

GeneCards

NRAS

HPA

ENSG00000213281-NRAS

Pharos - Targets

P01111

Orphanet

NRAS

ZINC - Predictions - Purchasable

RASN_HUMAN

HMDB Protein

HMDBP08527

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.932	15
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.863	8
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.615	4
UniProt:Q658P3 STEAP3	2	STEAP3 [endosome membrane] (R-HSA-917861) STEAP3 [plasma membrane] (R-HSA-9714848)	0.615	4
UniProt:P49354 FNTA	3	FNTA(2-379) [cytosol] (R-HSA-2530516) FNTA(1-59) [cytosol] (R-HSA-202869) FNTA(59-379) [cytosol] (R-HSA-202872)	0.564	3
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [secretory granule lumen] (R-HSA-6801479) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.547	2
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.527	2
UniProt:P53611 RABGGTB	2	RABGGTB [plasma membrane] (R-HSA-6801098) RABGGTB [cytosol] (R-HSA-8870419)	0.527	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.519	2
UniProt:Q99N57	11	phospho-p-S338,Y340,Y341-RAF1 [cytosol] (R-MMU-5624465) phospho-p-S338-RAF1 [cytosol] (R-MMU-5624469) phospho-hyperphosphorylated RAF1 [plasma membrane] (R-MMU-5675193) phospho-p-S621-RAF1 [plasma membrane] (R-MMU-206222) phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5675420) phospho-p-S259,S621-RAF1 [cytosol] (R-MMU-109786) RAF1 [cytosol] (R-MMU-167205) phospho-p-Y-RAF1 [cytosol] (R-MMU-9732747) phospho-p-S621-RAF1 [cytosol] (R-MMU-206028) phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5672665) phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-MMU-5672664)	0.499	2
UniProt:P28028	6	BRAF [cytosol] (R-MMU-167224) phospho-hyperphosphorylated BRAF [plasma membrane] (R-MMU-5675199) phospho-p-S365,S446,S729 BRAF [cytosol] (R-MMU-5672667) phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (R-MMU-5672679) phospho-p-S446,S729-BRAF [cytosol] (R-MMU-5672673) phospho-p-S446,T599,S602,S729 BRAF [cytosol] (R-MMU-5672676)	0.499	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.483	3
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.483	2
UniProt:O00400 SLC33A1	4	SLC33A1 A110P [Golgi membrane] (R-HSA-5649754) SLC33A1 S113R [Golgi membrane] (R-HSA-5649751) SLC33A1 Y366* [Golgi membrane] (R-HSA-5649750) SLC33A1 [Golgi membrane] (R-HSA-727745)	0.483	2
UniProt:P20020 ATP2B1	1	ATP2B1 [plasma membrane] (R-HSA-418301)	0.483	2
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.483	2
UniProt:P60468 SEC61B	3	SEC61B [cytosol] (R-HSA-5250571) SEC61B [endoplasmic reticulum membrane] (R-HSA-264899) SEC61B [phagocytic vesicle membrane] (R-HSA-1236882)	0.483	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.483	3
UniProt:Q15758 SLC1A5	1	SLC1A5 [plasma membrane] (R-HSA-352376)	0.483	3
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.483	2
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.483	2
UniProt:P41440 SLC19A1	1	SLC19A1 [plasma membrane] (R-HSA-200737)	0.483	2
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.483	3
UniProt:Q96AA3 RFT1	2	RFT1 R67C [endoplasmic reticulum membrane] (R-HSA-4570578) RFT1 [endoplasmic reticulum membrane] (R-HSA-449255)	0.483	2
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.483	3
UniProt:Q96QD8 SLC38A2	1	SLC38A2 [plasma membrane] (R-HSA-352093)	0.483	2
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.483	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.483	2

Cite Us!