Reactome | CD3D [clathrin-coated endocytic vesicle membrane]

CD3D [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869079

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

T-cell surface glycoprotein CD3 delta chain, CD3D_HUMAN

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Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04234 CD3D

Gene Names

CD3D, T3D

Chain

signal peptide:1-21, chain:22-171

Reference Genes

BioGPS Gene:915 CD3D

COSMIC (genes):CD3D CD3D

CTD Gene:915 CD3D

dbSNP Gene:915 CD3D

ENSEMBL:ENSG00000167286 CD3D

HGNC:1673 CD3D

KEGG:hsa:915 CD3D

Monarch:915 CD3D

NCBI Gene:915 CD3D

OMIM:186790 CD3D

UCSC:P04234 CD3D

Reference Transcript

Other Identifiers

11723264_a_at

11758882_at

16745016

213539_PM_at

213539_at

2672576

3393752

3393753

3393754

3393755

3393756

3393757

3393758

3393759

3393760

3393761

3393762

3393763

3393764

3393765

38319_at

7952056

915

A_23_P138985

A_33_P3375541

GE60501

GO:0002250

GO:0002376

GO:0004888

GO:0005515

GO:0005737

GO:0005886

GO:0007166

GO:0009897

GO:0016020

GO:0030669

GO:0042101

GO:0042105

GO:0042802

GO:0045059

GO:0046631

GO:0050852

GO:0060089

HMNXSV003022896

Hs.95327.0.S1_3p_at

ILMN_1724643

ILMN_2261416

ILMN_2325837

PH_hs_0005206

PH_hs_0038333

TC11002347.hg

X03934_at

Participates

as a member of

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

p-Y149,Y160-CD3D [plasma membrane]

CD3D [plasma membrane]

Inferred To

CD3D [clathrin-coated endocytic vesicle membrane] (Bos taurus)

CD3D [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

CD3D [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

CD3D [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Cd3d [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Cd3d [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000723.1, NP_001035741.1, XP_016874032.1

OpenTargets

ENSG00000167286

ENSEMBL

ENSP00000376622, ENSP00000300692, ENST00000300692, ENST00000392884

HPA

ENSG00000167286-CD3D

PRO

P04234

Pharos - Targets

P04234

Orphanet

CD3D

GlyGen

P04234

PDB

8JC0, 6JXR, 1XIW, 7PHR, 7FJE, 7FJD, 7FJF, 8ES8, 8ES7, 8JCB, 8ES9, 8YC0, 8WXE, 8WYI, 8WY0

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	2

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