Reactome | CD3D [clathrin-coated endocytic vesicle membrane]

CD3D [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869079

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

T-cell surface glycoprotein CD3 delta chain, CD3D_HUMAN

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Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CD3D [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04234 CD3D

Gene Names

CD3D, T3D

Chain

signal peptide:1-21, chain:22-171

Reference Genes

BioGPS Gene:915 CD3D

COSMIC (genes):CD3D CD3D

CTD Gene:915 CD3D

dbSNP Gene:915 CD3D

ENSEMBL:ENSG00000167286 CD3D

HGNC:1673 CD3D

KEGG Gene (Homo sapiens):915 CD3D

Monarch:915 CD3D

NCBI Gene:915 CD3D

OMIM:186790 CD3D

UCSC:P04234 CD3D

Reference Transcript

Other Identifiers

0001770121

11723264_a_at

13055

16745016

1XIW

213539_at

3393754

3393755

3393756

3393758

3393759

3393760

3393764

3393765

38319_at

7952056

915

A_23_P138985

A_33_P3375541

AAA51792

AAH39035

AAH70321

ACA05962

AK311971

AP001582

B0YIY4

BAG34910

BC039035

BC070321

CAA25683

CAA27573

CAB013055

CCDS41724

CCDS8394

CD014058

CD3D

CD3D-201

CD3D-202

CH471065

E9PMT5

EAW67365

EF444964

ENSG00000167286

ENSP00000300692

ENSP00000376622

ENST00000300692

ENST00000300692.8

ENST00000392884

ENST00000392884.2

EntrezGene:915

EntrezGene:CD3D

GE60501

GO:0002250

GO:0002376

GO:0003674

GO:0003713

GO:0004888

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005886

GO:0007165

GO:0007166

GO:0008150

GO:0009058

GO:0009897

GO:0016020

GO:0016021

GO:0022607

GO:0030154

GO:0030217

GO:0030665

GO:0031410

GO:0032991

GO:0034641

GO:0042101

GO:0042105

GO:0042803

GO:0043226

GO:0045059

GO:0045944

GO:0046982

GO:0048856

GO:0050776

GO:0050852

GO:0051260

GO:0061024

GO:0065003

HGNC:1673

Hs.95327.0.S1_3p_at

ILMN_2261416

ILMN_2325837

IPR003110

IPR013783

IPR015484

IPR015485

IPR032052

IPR036179

LRG_37

LRG_37t1

M12726

M12727

MIM:186790

MIM:615617

NM_000732

NM_001040651

NP_000723

NP_001035741

PF02189

PF16680

PH_hs_0005206

PH_hs_0038333

SM00077

TC11002347.hg

UPI0000127356

UPI0000405484

X01451

X03934

X03934_at

Participant Of

hasMember

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

CD3D [plasma membrane]

p-Y149,Y160-CD3D [plasma membrane]

Inferred To

CD3D [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

CD3D [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

CD3D [clathrin-coated endocytic vesicle membrane] (Mus musculus)

CD3D [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

CD3D [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

CD3D [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001035741.1, XP_016874032.1, NP_000723.1

OpenTargets

ENSG00000167286

GeneCards

P04234

PRO

P04234

Orphanet

17285

PDB

1XIW, 6JXR