Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LNPEP [early endosome lumen]
Stable Identifier
R-HSA-1236834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome lumen
Synonyms
IRAP, LAP, Leucyl-cystinyl aminopeptidase, LNPEP, LCAP_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Endosomal/Vacuolar pathway (Homo sapiens)
Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)
IRAP in complex with MHC class I [early endosome membrane] (Homo sapiens)
LNPEP [early endosome lumen] (Homo sapiens)
LNPEP [early endosome lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UIQ6 LNPEP
Gene Names
LNPEP, OTASE
Chain
chain:1-1025, chain:155-1025
Reference Genes
COSMIC (genes):LNPEP LNPEP
dbSNP Gene:4012 LNPEP
ENSEMBL:ENSG00000113441 LNPEP
Participates
as a component of
IRAP in complex with MHC class I [early endosome membrane] (Homo sapiens)
Other forms of this molecule
LNPEP [cytoplasmic vesicle membrane]
LNPEP [cytosol]
Inferred To
LNPEP [early endosome lumen]
(Bos taurus)
LNPEP [early endosome lumen]
(Canis familiaris)
LNPEP [early endosome lumen]
(Gallus gallus)
LNPEP [early endosome lumen]
(Mus musculus)
LNPEP [early endosome lumen]
(Rattus norvegicus)
LNPEP [early endosome lumen]
(Sus scrofa)
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.643
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text