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STIM1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-434675
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Stromal interaction molecule 1, STIM1_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1:TRPC1 [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 oligomerizes (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1:Calcium [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)
STIM1:TRPC1 [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)
STIM1:TRPC1 [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13586 STIM1
Gene Names
STIM1, GOK
Chain
signal peptide:1-22, chain:23-685
Reference Genes
BioGPS Gene:6786 STIM1
COSMIC (genes):STIM1 STIM1
CTD Gene:6786 STIM1
dbSNP Gene:6786 STIM1
ENSEMBL:ENSG00000167323 STIM1
HGNC:11386 STIM1
KEGG:hsa:6786 STIM1
Monarch:6786 STIM1
NCBI Gene:6786 STIM1
OMIM:605921 STIM1
UCSC:Q13586 STIM1
Reference Transcript
RefSeq:NM_001277962.1 STIM1
RefSeq:NM_003156.3 STIM1
Other Identifiers
11716845_at
16721085
202764_PM_at
202764_at
3317916
3317917
3317918
3317919
3317923
3317924
3317938
3317944
3317945
3317968
3317972
3317974
3317975
3317980
3317982
3317983
3317984
3317985
3317986
3317987
3317988
3317989
3317990
3317991
3317992
3317993
3317994
3317995
3317997
3317998
3317999
3318000
3318002
3318003
3318008
3318010
3318011
3318012
3318013
3318014
36900_at
67447_at
6786
7937900
ADDON000101.hg
A_21_P0007140
A_23_P53162
A_24_P889527
GE59228
GE620916
GO:0002020
GO:0002115
GO:0005246
GO:0005509
GO:0005513
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005856
GO:0005874
GO:0005886
GO:0006816
GO:0006874
GO:0008092
GO:0016020
GO:0016529
GO:0032237
GO:0032541
GO:0033017
GO:0042802
GO:0043226
GO:0044853
GO:0045762
GO:0045766
GO:0046872
GO:0048856
GO:0051010
GO:0051049
GO:0051924
GO:0070166
GO:0098772
GO:2001256
HMNXSV003019704
HMNXSV003023976
HMNXSV003049413
HMNXSV003051893
ILMN_2064694
PH_hs_0004255
TC11000088.hg
TC11002532.hg
TC11002533.hg
U52426_at
g4507268_3p_at
g4507268_3p_x_at
p2626
Participates
as a component of
STIM1:Calcium [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
stim1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
STIM1 [endoplasmic reticulum membrane]
(Bos taurus)
STIM1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
STIM1 [endoplasmic reticulum membrane]
(Canis familiaris)
STIM1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
STIM1 [endoplasmic reticulum membrane]
(Gallus gallus)
STIM1 [endoplasmic reticulum membrane]
(Mus musculus)
STIM1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
STIM1 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001264891.1
,
NP_003147.2
ENSEMBL
ENST00000300737
,
ENSP00000300737
,
ENSP00000436208
,
ENSG00000167323
,
ENST00000527651
OpenTargets
ENSG00000167323
GeneCards
STIM1
HPA
ENSG00000167323-STIM1
PRO
Q13586
Pharos - Targets
Q13586
GlyGen
Q13586
Orphanet
STIM1
HMDB Protein
HMDBP08015
PDB
3TEQ
,
2MAJ
,
2MAK
,
2K60
,
6YEL
,
4O9B
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48995 TRPC1
1
TRPC1 [plasma membrane]
(R-HSA-2089937)
0.641
6
UniProt:P62157 CALM
1
Calmodulin [cytosol]
(R-BTA-74015)
0.558
2
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.556
3
UniProt:P30101 PDIA3
3
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.543
3
UniProt:Q9NRM6 IL17RB
1
IL17RB [plasma membrane]
(R-HSA-447257)
0.527
2
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.508
2
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.483
3
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