Reactome | STIM1 [endoplasmic reticulum membrane]

STIM1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-434675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Stromal interaction molecule 1, STIM1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13586 STIM1

Gene Names

STIM1, GOK

Chain

signal peptide:1-22, chain:23-685

Reference Genes

BioGPS Gene:6786 STIM1

COSMIC (genes):STIM1 STIM1

CTD Gene:6786 STIM1

dbSNP Gene:6786 STIM1

ENSEMBL:ENSG00000167323 STIM1

HGNC:11386 STIM1

KEGG:hsa:6786 STIM1

Monarch:6786 STIM1

NCBI Gene:6786 STIM1

OMIM:605921 STIM1

UCSC:Q13586 STIM1

Reference Transcript

Other Identifiers

11716845_at

16721085

202764_PM_at

202764_at

3317916

3317917

3317918

3317919

3317923

3317924

3317938

3317944

3317945

3317968

3317972

3317974

3317975

3317980

3317982

3317983

3317984

3317985

3317986

3317987

3317988

3317989

3317990

3317991

3317992

3317993

3317994

3317995

3317997

3317998

3317999

3318000

3318002

3318003

3318008

3318010

3318011

3318012

3318013

3318014

36900_at

67447_at

6786

7937900

ADDON000101.hg

A_21_P0007140

A_23_P53162

A_24_P889527

GE59228

GE620916

GO:0002020

GO:0002115

GO:0005246

GO:0005509

GO:0005513

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005856

GO:0005874

GO:0005886

GO:0006816

GO:0006874

GO:0008092

GO:0016020

GO:0016529

GO:0032237

GO:0032541

GO:0033017

GO:0042802

GO:0043226

GO:0044853

GO:0045762

GO:0045766

GO:0046872

GO:0048856

GO:0051010

GO:0051049

GO:0051924

GO:0070166

GO:0098772

GO:2001256

HMNXSV003019704

HMNXSV003023976

HMNXSV003049413

HMNXSV003051893

ILMN_2064694

PH_hs_0004255

TC11000088.hg

TC11002532.hg

TC11002533.hg

U52426_at

g4507268_3p_at

g4507268_3p_x_at

p2626

Participates

as a component of

Inferred To

stim1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

STIM1 [endoplasmic reticulum membrane] (Bos taurus)

STIM1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

STIM1 [endoplasmic reticulum membrane] (Canis familiaris)

STIM1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

STIM1 [endoplasmic reticulum membrane] (Gallus gallus)

STIM1 [endoplasmic reticulum membrane] (Mus musculus)

STIM1 [endoplasmic reticulum membrane] (Rattus norvegicus)

STIM1 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001264891.1, NP_003147.2

ENSEMBL

ENST00000300737, ENSP00000300737, ENSP00000436208, ENSG00000167323, ENST00000527651

OpenTargets

ENSG00000167323

GeneCards

STIM1

HPA

ENSG00000167323-STIM1

PRO

Q13586

Pharos - Targets

Q13586

GlyGen

Q13586

Orphanet

STIM1

HMDB Protein

HMDBP08015

PDB

3TEQ, 2MAJ, 2MAK, 2K60, 6YEL, 4O9B

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48995 TRPC1	1	TRPC1 [plasma membrane] (R-HSA-2089937)	0.641	6
UniProt:P62157 CALM	1	Calmodulin [cytosol] (R-BTA-74015)	0.558	2
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P30101 PDIA3	3	PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.543	3
UniProt:Q9NRM6 IL17RB	1	IL17RB [plasma membrane] (R-HSA-447257)	0.527	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	3