Reactome | STIM1 [endoplasmic reticulum membrane]

STIM1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-434675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Stromal interaction molecule 1, STIM1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13586 STIM1

Gene Names

STIM1, GOK

Chain

signal peptide:1-22, chain:23-685

Reference Genes

BioGPS Gene:6786 STIM1

COSMIC (genes):STIM1 STIM1

CTD Gene:6786 STIM1

dbSNP Gene:6786 STIM1

ENSEMBL:ENSG00000167323.12 STIM1

HGNC:11386 STIM1

KEGG Gene (Homo sapiens):6786 STIM1

Monarch:6786 STIM1

NCBI Gene:6786 STIM1

OMIM:605921 STIM1

UCSC:Q13586 STIM1

Reference Transcript

Other Identifiers

0003840040

11716845_at

16721085

202764_PM_at

202764_at

3317917

3317918

3317919

3317944

3317968

3317972

3317974

3317980

3317982

3317983

3317984

3317985

3317990

3317997

3317998

3317999

3318000

3318008

36900_at

67447_at

6786

7937900

A_21_P0007140

A_23_P53162

A_24_P889527

GE59228

GO:0002020

GO:0002115

GO:0005246

GO:0005509

GO:0005513

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005856

GO:0005874

GO:0005886

GO:0005887

GO:0006811

GO:0006816

GO:0006874

GO:0008092

GO:0016020

GO:0016021

GO:0016529

GO:0030176

GO:0032237

GO:0032541

GO:0033017

GO:0042802

GO:0043226

GO:0043229

GO:0044853

GO:0045762

GO:0045766

GO:0046872

GO:0048856

GO:0051010

GO:0051924

GO:0055065

GO:0055085

GO:0070166

GO:0098772

GO:2001256

HMNXSV003023976

HMNXSV003049413

HMNXSV003051893

ILMN_1797502

ILMN_1880243

ILMN_2064694

PH_hs_0004255

TC11000088.hg

U52426_at

g4507268_3p_at

g4507268_3p_x_at

p2626

Participates

as a component of

Inferred To

stim1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

STIM1 [endoplasmic reticulum membrane] (Bos taurus)

STIM1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

STIM1 [endoplasmic reticulum membrane] (Canis familiaris)

STIM1 [endoplasmic reticulum membrane] (Danio rerio)

STIM1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

STIM1 [endoplasmic reticulum membrane] (Gallus gallus)

STIM1 [endoplasmic reticulum membrane] (Mus musculus)

STIM1 [endoplasmic reticulum membrane] (Rattus norvegicus)

STIM1 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001264891.1, NP_003147.2

OpenTargets

ENSG00000167323

GeneCards

Q13586

HPA

ENSG00000167323-STIM1

Ensembl

ENSG00000167323, ENST00000300737, ENSP00000300737, ENST00000527651, ENSP00000436208

PRO

Q13586

Pharos - Targets

Q13586

Orphanet

18444

HMDB Protein

HMDBP08015

PDB

2MAK, 6YEL, 4O9B, 2MAJ, 2K60, 3TEQ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48995 TRPC1	1	TRPC1 [plasma membrane] (R-HSA-2089937)	0.641	6
UniProt:P62157 CALM	1	Calmodulin [cytosol] (R-BTA-74015)	0.558	2
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.543	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	2