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STIM1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-434675
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Stromal interaction molecule 1, STIM1_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1:TRPC1 [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 oligomerizes (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
STIM1:Calcium [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)
STIM1:TRPC1 [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)
STIM1:TRPC1 [plasma membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13586 STIM1
Gene Names
STIM1, GOK
Chain
signal peptide:1-22, chain:23-685
Reference Genes
BioGPS Gene:6786 STIM1
COSMIC (genes):STIM1 STIM1
CTD Gene:6786 STIM1
dbSNP Gene:6786 STIM1
ENSEMBL:ENSG00000167323.12 STIM1
HGNC:11386 STIM1
KEGG Gene (Homo sapiens):6786 STIM1
Monarch:6786 STIM1
NCBI Gene:6786 STIM1
OMIM:605921 STIM1
UCSC:Q13586 STIM1
Reference Transcript
RefSeq:NM_001277962.1 STIM1
RefSeq:NM_003156.3 STIM1
Other Identifiers
0003840040
11716845_at
16721085
202764_PM_at
202764_at
3317917
3317918
3317919
3317944
3317968
3317972
3317974
3317980
3317982
3317983
3317984
3317985
3317990
3317997
3317998
3317999
3318000
3318008
36900_at
67447_at
6786
7937900
A_21_P0007140
A_23_P53162
A_24_P889527
GE59228
GO:0002020
GO:0002115
GO:0005246
GO:0005509
GO:0005513
GO:0005515
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005856
GO:0005874
GO:0005886
GO:0005887
GO:0006811
GO:0006816
GO:0006874
GO:0008092
GO:0016020
GO:0016021
GO:0016529
GO:0030176
GO:0032237
GO:0032541
GO:0033017
GO:0042802
GO:0043226
GO:0043229
GO:0044853
GO:0045762
GO:0045766
GO:0046872
GO:0048856
GO:0051010
GO:0051924
GO:0055065
GO:0055085
GO:0070166
GO:0098772
GO:2001256
HMNXSV003023976
HMNXSV003049413
HMNXSV003051893
ILMN_1797502
ILMN_1880243
ILMN_2064694
PH_hs_0004255
TC11000088.hg
U52426_at
g4507268_3p_at
g4507268_3p_x_at
p2626
Participates
as a component of
STIM1:Calcium [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 Dimer [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
stim1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
STIM1 [endoplasmic reticulum membrane]
(Bos taurus)
STIM1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
STIM1 [endoplasmic reticulum membrane]
(Canis familiaris)
STIM1 [endoplasmic reticulum membrane]
(Danio rerio)
STIM1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
STIM1 [endoplasmic reticulum membrane]
(Gallus gallus)
STIM1 [endoplasmic reticulum membrane]
(Mus musculus)
STIM1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
STIM1 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001264891.1
,
NP_003147.2
OpenTargets
ENSG00000167323
GeneCards
Q13586
HPA
ENSG00000167323-STIM1
Ensembl
ENSG00000167323
,
ENST00000300737
,
ENSP00000300737
,
ENST00000527651
,
ENSP00000436208
PRO
Q13586
Pharos - Targets
Q13586
Orphanet
18444
HMDB Protein
HMDBP08015
PDB
2MAK
,
6YEL
,
4O9B
,
2MAJ
,
2K60
,
3TEQ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48995 TRPC1
1
TRPC1 [plasma membrane]
(R-HSA-2089937)
0.641
6
UniProt:P62157 CALM
1
Calmodulin [cytosol]
(R-BTA-74015)
0.558
2
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
UniProt:P30101 PDIA3
3
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.543
3
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.508
2
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