Reactome | IGF2R [plasma membrane]

IGF2R [plasma membrane]

Stable Identifier

R-HSA-6806532

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cation-independent mannose-6-phosphate receptor, MPRI_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - AP-2 directly binds some endocytic cargo (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IGF2R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11717 IGF2R

Gene Names

IGF2R, MPRI

Chain

signal peptide:1-40, chain:41-2491

Reference Genes

BioGPS Gene:3482 IGF2R

COSMIC (genes):IGF2R IGF2R

CTD Gene:3482 IGF2R

dbSNP Gene:3482 IGF2R

ENSEMBL:ENSG00000197081 IGF2R

HGNC:5467 IGF2R

KEGG:hsa:3482 IGF2R

Monarch:3482 IGF2R

NCBI Gene:3482 IGF2R

OMIM:147280 IGF2R

UCSC:P11717 IGF2R

Reference Transcript

RefSeq:NM_000876.3 IGF2R

Other Identifiers

11716128_at

11716129_at

11753961_a_at

1569052_PM_at

1569052_at

160027_s_at

17014364

17014421

201392_PM_s_at

201392_s_at

201393_PM_s_at

201393_s_at

2934310

2934311

2934312

2934314

2934319

2934320

2934322

2934327

2934329

2934332

2934338

2934339

2934340

2934341

2934342

2934349

2934351

2934352

2934353

2934354

2934355

2934356

2934360

2934361

2934362

2934363

2934365

2934367

2934368

2934370

2934372

2934373

2934374

2934375

2934377

2934379

2934381

2934382

2934383

2934384

2934388

2934391

2934392

2934394

2934395

2934396

2934397

2934398

2934401

2934402

2934403

2934405

2934407

2934408

2934409

2934410

2934418

2934419

2934420

2934421

2934422

2934423

2934424

2934425

2934426

2934427

2934428

2934429

2934431

2934432

2934433

2934435

2934436

2934437

2934438

2934439

2934440

2934442

2934443

2934445

2934447

2934449

2934450

2934452

2934453

3482

8123181

8123230

972_s_at

A_14_P119493

A_23_P156953

A_23_P334021

A_24_P27415

A_33_P3410859

GE60227

GE613451

GO:0000139

GO:0001889

GO:0001965

GO:0001972

GO:0003824

GO:0005010

GO:0005515

GO:0005520

GO:0005537

GO:0005615

GO:0005634

GO:0005641

GO:0005768

GO:0005769

GO:0005770

GO:0005794

GO:0005802

GO:0005886

GO:0005925

GO:0006898

GO:0007041

GO:0007165

GO:0007186

GO:0007283

GO:0008289

GO:0009791

GO:0009986

GO:0010008

GO:0016020

GO:0016192

GO:0016740

GO:0019899

GO:0022414

GO:0030118

GO:0030133

GO:0030139

GO:0030140

GO:0030667

GO:0030669

GO:0031100

GO:0031410

GO:0031995

GO:0032526

GO:0032588

GO:0038023

GO:0042802

GO:0042981

GO:0043065

GO:0043226

GO:0044794

GO:0048009

GO:0048471

GO:0048856

GO:0051219

GO:0060089

GO:0070062

GO:0140096

GO:1904772

GO:1905394

HMNXSV003007415

HMNXSV003035406

Hs.76473.0.S1_3p_a_at

Hs2.391924.1.S1_3p_at

Hs2.391924.1.S1_3p_x_at

ILMN_1807662

ILMN_2180519

PH_hs_0004415

PH_hs_0018933

TC06001152.hg

TC06001153.hg

TC06003169.hg

Y00285_s_at

g4504610_3p_a_at

p34647

Participates

as a member of

Other forms of this molecule

IGF2R [secretory granule membrane]

IGF2R [trans-Golgi network membrane]

IGF2R [transport vesicle]

IGF2R [cytoplasmic vesicle membrane]

IGF2R [Golgi membrane]

IGF2R [clathrin-coated endocytic vesicle membrane]

Inferred To

Igf2r [plasma membrane] (Mus musculus)

Igf2r [plasma membrane] (Rattus norvegicus)

IGF2R [plasma membrane] (Bos taurus)

IGF2R [plasma membrane] (Dictyostelium discoideum)

IGF2R [plasma membrane] (Gallus gallus)

IGF2R [plasma membrane] (Sus scrofa)

Lerp [plasma membrane] (Drosophila melanogaster)

CI-MPR/IGF2R [plasma membrane] (Canis familiaris)

igf2r [plasma membrane] (Danio rerio)

igf2r [plasma membrane] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000197081

ENSEMBL

ENSP00000349437, ENST00000356956

HPA

ENSG00000197081-IGF2R

ZINC - Substances

MPRI_HUMAN

ZINC target

P11717

PRO

P11717

Pharos - Targets

P11717

GlyGen

P11717

ZINC - Predictions - Purchasable

MPRI_HUMAN

HMDB Protein

HMDBP01754

PDB

8AFZ, 2M6T, 1JWG, 2V5O, 1LF8, 2V5P, 2M68, 1JPL, 1GP0, 6Z30, 1GQB, 2L29, 1E6F, 6P8I, 6V02, 6Z32, 5IEI, 6Z31, 6N5X, 2CNJ, 1GP3, 2L2A, 6N5Y, 2V5N

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.761	8
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	2

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