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MBTPS1 [Golgi membrane]
Stable Identifier
R-HSA-381108
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
S1P
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
ATF6B (ATF6-beta) activates chaperones (Homo sapiens)
MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
CREB3 factors activate genes (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L1 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L3 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L4 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14703 MBTPS1
Gene Names
MBTPS1, KIAA0091, S1P, SKI1
Chain
signal peptide:1-17, propeptide:18-186, chain:187-1052
Reference Genes
BioGPS Gene:8720 MBTPS1
COSMIC (genes):MBTPS1 MBTPS1
CTD Gene:8720 MBTPS1
dbSNP Gene:8720 MBTPS1
ENSEMBL:ENSG00000140943 MBTPS1
HGNC:15456 MBTPS1
KEGG:hsa:8720 MBTPS1
Monarch:8720 MBTPS1
NCBI Entrez Gene:8720 MBTPS1
OMIM:603355 MBTPS1
UCSC:Q14703 MBTPS1
Reference Transcript
RefSeq:XM_054314251.1 MBTPS1
RefSeq:XM_047434831.1 MBTPS1
RefSeq:XM_054314252.1 MBTPS1
RefSeq:XM_047434830.1 MBTPS1
RefSeq:NM_003791.4 MBTPS1
Other Identifiers
11715952_a_at
11715953_a_at
11761238_at
16828734
201620_PM_at
201620_at
217543_3p_s_at
217543_PM_s_at
217543_s_at
36964_at
3702292
3702294
3702295
3702296
3702297
3702304
3702305
3702306
3702307
3702308
3702309
3702310
3702311
3702312
3702314
3702316
3702320
3702322
3702323
3702324
3702325
3702326
3702327
3702328
3702329
3702332
3702333
3702334
3702336
3702337
3702339
3702340
3702341
3702342
3702343
3702345
3702346
3702347
3702348
3702351
8003089
82482_r_at
8720
A_23_P14946
A_23_P14948
A_24_P378368
A_33_P3393941
D42053_at
GE57205
GE83849
GO:0000139
GO:0004252
GO:0005515
GO:0005783
GO:0005788
GO:0005789
GO:0005794
GO:0005795
GO:0006508
GO:0006607
GO:0006629
GO:0006886
GO:0006913
GO:0007040
GO:0007095
GO:0008202
GO:0008203
GO:0008233
GO:0008236
GO:0016020
GO:0016485
GO:0016787
GO:0030968
GO:0031293
GO:0034976
GO:0036500
GO:0045540
GO:0045542
GO:0051604
GO:0060627
HMNXSV003028178
Hs.314499.0.A1_3p_at
Hs.314499.0.A1_3p_x_at
ILMN_1651719
ILMN_1767256
PH_hs_0004384
TC16001307.hg
TC16001988.hg
g4506774_3p_s_at
Other forms of this molecule
MBTPS1 [endoplasmic reticulum membrane]
p-MBTPS1 [endoplasmic reticulum lumen]
MBTPS1 [endoplasmic reticulum lumen]
Inferred To
Mbtps1 [Golgi membrane]
(Mus musculus)
Mbtps1 [Golgi membrane]
(Rattus norvegicus)
S1P [Golgi membrane]
(Drosophila melanogaster)
MBTPS1 [Golgi membrane]
(Bos taurus)
MBTPS1 [Golgi membrane]
(Canis familiaris)
MBTPS1 [Golgi membrane]
(Dictyostelium discoideum)
MBTPS1 [Golgi membrane]
(Gallus gallus)
MBTPS1 [Golgi membrane]
(Sus scrofa)
mbtps1 [Golgi membrane]
(Danio rerio)
mbtps1 [Golgi membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_047290787.1
,
NP_003782.1
,
XP_054170226.1
,
XP_047290786.1
,
XP_054170227.1
Guide to Pharmacology - Targets
2381
ENSEMBL
ENST00000343411
,
ENSG00000140943
,
ENSP00000344223
OpenTargets
ENSG00000140943
ZINC - Substances
MBTP1_HUMAN
ZINC target
Q14703
PRO
Q14703
GlyGen
Q14703
PDB
8UW8
,
8UWC
GeneCards
MBTPS1
HPA
ENSG00000140943-MBTPS1
Pharos - Targets
Q14703
ZINC - Predictions - Purchasable
MBTP1_HUMAN
HMDB Protein
HMDBP02784
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
3
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum membrane]
(R-HSA-9932989)
0.643
3
UniProt:O14967 CLGN
0.527
2
UniProt:Q8IV16 GPIHBP1
3
GPIHBP1 [plasma membrane]
(R-HSA-5216067)
GPI-GPIHBP1 [plasma membrane]
(R-HSA-8940783)
cleaved GPI-GPIHBP1 [extracellular region]
(R-HSA-8941062)
0.527
3
UniProt:Q8WWF1 CA054
0.527
3
UniProt:Q9Y240 CLC11
0.527
2
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