Reactome | p-S71,S86-LBR [nuclear envelope]

p-S71,S86-LBR [nuclear envelope]

Stable Identifier

R-HSA-9624811

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14739 LBR

Gene Names

LBR

Chain

chain:1-615

Reference Genes

BioGPS Gene:3930 LBR

COSMIC (genes):LBR LBR

CTD Gene:3930 LBR

dbSNP Gene:3930 LBR

ENSEMBL:ENSG00000143815 LBR

ENSEMBL_homo_sapiens_GENE:ENSG00000143815.15 LBR

HGNC:6518 LBR

KEGG Gene (Homo sapiens):3930 LBR

Monarch:3930 LBR

NCBI Gene:3930 LBR

OMIM:600024 LBR

UCSC:Q14739 LBR

Reference Transcript

Other Identifiers

11716797_s_at

11751573_a_at

16699877

201795_PM_at

201795_at

2458290

2458291

2458292

2458293

2458295

2458296

2458299

2458301

2458303

2458305

2458306

2458310

2458311

2458312

2458313

2458314

2458316

2458321

2458322

288_s_at

3930

7924603

A_23_P200493

GE57697

GO:0003677

GO:0003723

GO:0003824

GO:0005515

GO:0005521

GO:0005634

GO:0005635

GO:0005637

GO:0005737

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006695

GO:0008202

GO:0008203

GO:0016020

GO:0016126

GO:0016491

GO:0016628

GO:0030154

GO:0030223

GO:0031965

GO:0043226

GO:0048856

GO:0050613

GO:0070087

GO:0070402

HMNXSV003005095

ILMN_1768969

ILMN_1810418

ILMN_2285480

L25931_s_at

PH_hs_0030224

TC01003887.hg

g4504960_3p_at

Participates

as a component of

p-S71,S86-LBR:KPNB1 [nuclear envelope] (Homo sapiens)

as an input of

LBR binds KPNB1 (Homo sapiens)

as an output of

CDK1 phosphorylates LBR (Homo sapiens)

Other forms of this molecule

LBR [nuclear envelope]

LBR [endoplasmic reticulum membrane]

LBR [endosome membrane]

Inferred To

phospho-LBR [nuclear envelope] (Bos taurus)

phospho-LBR [nuclear envelope] (Canis familiaris)

phospho-LBR [nuclear envelope] (Sus scrofa)

phospho-Lbr [nuclear envelope] (Mus musculus)

phospho-Lbr [nuclear envelope] (Rattus norvegicus)

phospho-lbr [nuclear envelope] (Danio rerio)

phospho-lbr [nuclear envelope] (Xenopus tropicalis)

phospho-p-S71,S86-LBR [nuclear envelope] (Dictyostelium discoideum)

phospho-p-S71,S86-LBR [nuclear envelope] (Gallus gallus)

phospho-p-S71,S86-LBR [nuclear envelope] (Saccharomyces cerevisiae)

phospho-p-S71,S86-LBR [nuclear envelope] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-serine at 71

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 86

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_011542487.1, NP_002287.2, NP_919424.1

OpenTargets

ENSG00000143815

GeneCards

Q14739

HPA

ENSG00000143815-LBR

Ensembl

ENSP00000272163, ENST00000338179, ENST00000272163, ENSP00000339883, ENSG00000143815

PRO

Q14739

Pharos - Targets

Q14739

Orphanet

16340

PDB

2DIG

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.749	5
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.617	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	4
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.605	4
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.564	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.564	2
UniProt:Q8NAF0 ZN579			0.564	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.556	3
UniProt:O75596 CLC3A			0.527	2
UniProt:P49761 CLK3			0.527	2
UniProt:Q7RTS1 BHA15			0.527	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q15013 MD2BP			0.527	2

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