Reactome | p-Y149,Y160-CD3D [plasma membrane]

p-Y149,Y160-CD3D [plasma membrane]

Stable Identifier

R-HSA-202329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD3 delta with phosphorylated ITAMs

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Costimulation by the CD28 family (Homo sapiens)
    - PD-1 signaling (Homo sapiens)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
  - TCR signaling (Homo sapiens)
    - Generation of second messenger molecules (Homo sapiens)
      - Phosphorylation of PLC-gamma1 (Homo sapiens)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
      - Phosphorylation of SLP-76 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
      - Phosphorylation of TBSMs in LAT (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
    - Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
      - Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
    - Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
      - Activation of ZAP-70 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
      - PTPN22 dephosphorylates ZAP70 (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
      - Phosphorylation of ZAP-70 by Lck (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04234 CD3D

Gene Names

CD3D, T3D

Chain

signal peptide:1-21, chain:22-171

Reference Genes

BioGPS Gene:915 CD3D

COSMIC (genes):CD3D CD3D

CTD Gene:915 CD3D

dbSNP Gene:915 CD3D

ENSEMBL:ENSG00000167286 CD3D

ENSEMBL:ENSG00000167286.11 CD3D

HGNC:1673 CD3D

KEGG Gene (Homo sapiens):915 CD3D

Monarch:915 CD3D

NCBI Gene:915 CD3D

OMIM:186790 CD3D

UCSC:P04234 CD3D

Reference Transcript

Other Identifiers

11723264_a_at

16745016

213539_PM_at

213539_at

3393754

3393755

3393756

3393758

3393759

3393760

3393764

3393765

38319_at

7952056

915

A_23_P138985

A_33_P3375541

GE60501

GO:0002250

GO:0002376

GO:0004888

GO:0005515

GO:0005737

GO:0005886

GO:0007166

GO:0009897

GO:0016020

GO:0023052

GO:0030154

GO:0030669

GO:0031410

GO:0042101

GO:0042105

GO:0042802

GO:0043226

GO:0045059

GO:0046631

GO:0048856

GO:0050852

GO:0060089

HMNXSV003022896

Hs.95327.0.S1_3p_at

ILMN_2261416

ILMN_2325837

PH_hs_0005206

PH_hs_0038333

TC11002347.hg

X03934_at

Participates

as a component of

CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)

Other forms of this molecule

CD3D [clathrin-coated endocytic vesicle membrane]

CD3D [plasma membrane]

Inferred To

phospho-Cd3d [plasma membrane] (Mus musculus)

phospho-Cd3d [plasma membrane] (Rattus norvegicus)

phospho-p-Y149,Y160-CD3D [plasma membrane] (Canis familiaris)

phospho-p-Y149,Y160-CD3D [plasma membrane] (Gallus gallus)

phospho-cd3g [plasma membrane] (Xenopus tropicalis)

phospho-CD3D [plasma membrane] (Bos taurus)

phospho-CD3D [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 149

Coordinate

149

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 160

Coordinate

160

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001035741.1, XP_016874032.1, NP_000723.1

OpenTargets

ENSG00000167286

GeneCards

P04234

HPA

ENSG00000167286-CD3D

Ensembl

ENST00000392884, ENSP00000376622, ENSG00000167286, ENSP00000300692, ENST00000300692

PRO

P04234

Pharos - Targets

P04234

Orphanet

17285

PDB

6JXR, 7FJE, 7PHR, 1XIW, 7FJD, 7FJF

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