Reactome | RPTOR [cytosol]

RPTOR [cytosol]

Stable Identifier

R-HSA-3006727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Regulatory-associated protein of mTOR, RPTOR_HUMAN

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Active MTORC1 binds the ULK1 complex (Homo sapiens)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Active MTORC1 phosphorylates ULK1 (Homo sapiens)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Amino acids regulate mTORC1 (Homo sapiens)
      - RRAGA,B hydrolyzes GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1 binds RHEB:GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN gene transcription (Homo sapiens)
        
        MAF1 translocates to the nucleus (Homo sapiens)
        
        MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
        
        mTORC1 phosphorylates MAF1 (Homo sapiens)
        
        MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
- MTOR signalling (Homo sapiens)
  - AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
    - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Formation of active mTORC1 complex (Homo sapiens)
    - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
      - mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)
    - mTORC1 [cytosol] (Homo sapiens)
      - RPTOR [cytosol] (Homo sapiens)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
      - mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - mTORC1 phosphorylates AKT1S1 (Homo sapiens)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - mTORC1-mediated signalling (Homo sapiens)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N122 RPTOR

Gene Names

RPTOR, KIAA1303, RAPTOR

Chain

chain:1-1335

Reference Genes

BioGPS Gene:57521 RPTOR

COSMIC (genes):RPTOR RPTOR

CTD Gene:57521 RPTOR

dbSNP Gene:57521 RPTOR

ENSEMBL:ENSG00000141564 RPTOR

ENSEMBL_homo_sapiens_GENE:ENSG00000141564.16 RPTOR

HGNC:30287 RPTOR

KEGG Gene (Homo sapiens):57521 RPTOR

Monarch:57521 RPTOR

NCBI Gene:57521 RPTOR

OMIM:607130 RPTOR

UCSC:Q8N122 RPTOR

Reference Transcript

Other Identifiers

11722496_a_at

11722497_a_at

11722498_s_at

11745456_a_at

11752252_a_at

16838698

225715_PM_at

225715_at

3737489

3737490

3737491

3737500

3737502

3737519

3737528

3737534

3737539

3737551

3737552

3737553

3737560

3737563

3737565

3737568

3737578

3737581

3737582

3737583

3737584

3737585

3737586

3737593

3737601

3737602

3737604

3737608

3737614

3737615

3737617

3737621

3737623

3737624

3737625

3737626

3737627

3737628

56274_at

57521

8010512

A_14_P113638

A_14_P125470

A_23_P384499

GE53894

GO:0000278

GO:0001558

GO:0001938

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0006629

GO:0006914

GO:0006974

GO:0008361

GO:0009267

GO:0009410

GO:0010494

GO:0010506

GO:0010507

GO:0010800

GO:0016020

GO:0019901

GO:0023052

GO:0030154

GO:0030291

GO:0030295

GO:0030307

GO:0030425

GO:0030674

GO:0031267

GO:0031669

GO:0031929

GO:0031931

GO:0032008

GO:0033138

GO:0035176

GO:0036211

GO:0038202

GO:0042325

GO:0043025

GO:0043226

GO:0044877

GO:0045672

GO:0045821

GO:0045945

GO:0046889

GO:0048856

GO:0055086

GO:0060090

GO:0071230

GO:0071233

GO:0071333

GO:0071456

GO:0071470

GO:0071889

GO:0098772

GO:0140767

GO:1900087

GO:1901135

GO:1901331

GO:1905857

HMNXSV003041280

Hs.20677.0.S1_3p_at

ILMN_1793514

ILMN_1797816

PH_hs_0023108

TC17000921.hg

Participates

as a component of

mTORC1 [cytosol] (Homo sapiens)

Other forms of this molecule

RPTOR [nucleoplasm]

p-S722,S792-RPTOR [cytosol]

Inferred To

mip1 [cytosol] (Schizosaccharomyces pombe)

rptor [cytosol] (Danio rerio)

rptor [cytosol] (Xenopus tropicalis)

RPTOR [cytosol] (Bos taurus)

RPTOR [cytosol] (Canis familiaris)

RPTOR [cytosol] (Gallus gallus)

RPTOR [cytosol] (Sus scrofa)

raptor [cytosol] (Dictyostelium discoideum)

raptor [cytosol] (Drosophila melanogaster)

KOG1 [cytosol] (Saccharomyces cerevisiae)

Rptor [cytosol] (Mus musculus)

Rptor [cytosol] (Rattus norvegicus)

daf-15 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_065812.1, NP_001156506.1

OpenTargets

ENSG00000141564

HPA

ENSG00000141564-RPTOR

GeneCards

Q8N122

Ensembl

ENST00000570891, ENSP00000460136, ENSP00000442479, ENST00000306801, ENSG00000141564, ENST00000544334, ENSP00000307272

PRO

Q8N122

Pharos - Targets

Q8N122

HMDB Protein

HMDBP13901

PDB

7OWG, 6SB0, 7UXC, 5H64, 6BCU, 7PEB, 6BCX, 6U62, 7UX2, 7UXH, 6SB2, 7PEA, 7PEC, 8ERA

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13541 EIF4EBP1	2	EIF4EBP1 [cytosol] (R-HSA-72580) p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685)	0.711	5
UniProt:Q96B36 AKT1S1	4	AKT1S1 [nucleoplasm] (R-HSA-5083637) p-T246-AKT1S1 [cytosol] (R-HSA-377124) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) AKT1S1 [cytosol] (R-HSA-200155)	0.669	5
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.643	4
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.643	4
UniProt:Q9UHA4 LAMTOR3	5	LAMTOR3 [specific granule membrane] (R-HSA-6800178) LAMTOR3 [plasma membrane] (R-HSA-6806307) LAMTOR3 [tertiary granule membrane] (R-HSA-6800189) LAMTOR3 [endosome membrane] (R-HSA-5693294) LAMTOR3 [lysosomal membrane] (R-HSA-5653581)	0.527	3
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.527	2
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.527	2
UniProt:P67999	2	RPS6KB1 [cytosol] (R-RNO-165716) phospho-p-T412-RPS6KB1 [cytosol] (R-RNO-165714)	0.499	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.499	3
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145)	0.499	3
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.499	6

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