V600E BRAF V169_M438del

Stable Identifier
R-HSA-6802489
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
External Reference Information
External Reference
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Transcript
Other Identifiers
11732491_s_at
1328
1654_at
17063631
1UWH
1UWJ
206044_s_at
2FB8
2L05
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3076441
3982166
3982173
3C4C
3D4Q
3IDP
3II5
3NY5
3OG7
3PPJ
3PPK
3PRF
3PRI
3PSB
3PSD
3Q4C
3Q96
3SKC
3TV4
3TV6
40306_at
4552
4CQE
4DBN
4E26
4E4X
4EHE
4EHG
4FC0
4FK3
4G9C
4G9R
4H58
4JVG
4KSP
4KSQ
4MBJ
4MNE
4MNF
4PP7
4R5Y
4RZV
4RZW
4WO5
4XV1
4XV2
4XV3
4XV9
4YHT
5C9C
5CSW
5CSX
5CT7
5FD2
5HI2
5HID
5HIE
5ITA
5J17
5J18
5J2R
5JRQ
5JSM
5JT2
673
71048
8143417
A_23_P42935
BRAF
BRAF-201
CAB004552
CCDS5863
ENSG00000157764
ENSP00000288602
ENST00000288602
EntrezGene:673
g4757867_3p_a_at
GE58163
GO:0000165
GO:0000166
GO:0000186
GO:0002318
GO:0004672
GO:0004674
GO:0004709
GO:0005057
GO:0005509
GO:0005515
GO:0005524
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006468
GO:0007165
GO:0008542
GO:0009887
GO:0009968
GO:0010628
GO:0010764
GO:0015758
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0030154
GO:0030878
GO:0031434
GO:0033138
GO:0035019
GO:0035556
GO:0035690
GO:0042127
GO:0042802
GO:0043005
GO:0043066
GO:0043231
GO:0043367
GO:0043368
GO:0043369
GO:0043434
GO:0043524
GO:0044297
GO:0045580
GO:0046632
GO:0046872
GO:0046982
GO:0048538
GO:0048679
GO:0048680
GO:0050772
GO:0050852
GO:0051291
GO:0051496
GO:0051591
GO:0060291
GO:0060323
GO:0060324
GO:0070374
GO:0071277
GO:0090150
GO:1900026
GO:1990090
GO:2000301
GO:2000352
HGNC:1097
HPA001328
HPA071048
ILMN_1652472
LRG_299
LRG_299t1
M95712_at
MIM:115150
MIM:163950
MIM:164757
MIM:211980
MIM:613706
MIM:613707
NM_004333
NP_001341538
NP_004324
PF00130
PF02196
PF07714
PH_hs_0027912
PR00008
SM00109
SM00220
SM00455
TC07001927.hg
uc003vwc.5
UPI000013DF26
XM_005250045
XM_017012558
XM_017012559
XP_016868047
XP_016868048
XR_001744857
XR_001744858
Participant Of
Other forms of this molecule
Modified Residues
Name
Deletion of residues 169 to 438
Name
L-valine 600 replaced with L-glutamic acid
Coordinate
600
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
A protein modification that effectively removes or replaces an L-valine.
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
melanoma 1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Cross References
RefSeq
Brenda
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Metabolites
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q02750 MAP2K1  7 0.976 58
 UniProt:P04049 RAF1  11 0.957 55
 UniProt:P15056 BRAF  35 0.907 13
 UniProt:P63104 YWHAZ  2 0.822 6
 UniProt:P31946 YWHAB  2 0.763 5
 UniProt:P01112 HRAS  8 0.719 4
 UniProt:P61981 YWHAG  1 0.688 3
 UniProt:P27348 YWHAQ  1 0.688 3
 UniProt:P10398 ARAF  4 0.669 3
 UniProt:P36507 MAP2K2  5 0.669 6
 UniProt:Q13233 MAP3K1  2 0.609 2
 UniProt:P01111 NRAS  8 0.591 3
 UniProt:P08238 HSP90AB1  5 0.564 2
 UniProt:P46940 IQGAP1  3 0.544 4
 UniProt:Q61097  5 0.499 3
 UniProt:Q99N57  11 0.499 3