Reactome | PPARD [nucleoplasm]

PPARD [nucleoplasm]

Stable Identifier

R-HSA-446176

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor delta, PPARD_HUMAN

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Carnitine metabolism (Homo sapiens)
      - CPT1A,B transfers PALM to CAR (Homo sapiens)
        
        RXRA:PPARD:atRA [nucleoplasm] (Homo sapiens)
        
        RXRA:PPARD [nucleoplasm] (Homo sapiens)
        
        PPARD [nucleoplasm] (Homo sapiens)
- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
    - Pyruvate metabolism (Homo sapiens)
      - Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
        
        PDK isoforms phosphorylate lipo-PDH (Homo sapiens)
        
        RXRA:PPARD:atRA [nucleoplasm] (Homo sapiens)
        
        RXRA:PPARD [nucleoplasm] (Homo sapiens)
        
        PPARD [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03181 PPARD

Gene Names

PPARD, NR1C2, PPARB

Chain

chain:1-441

Reference Genes

BioGPS Gene:5467 PPARD

COSMIC (genes):PPARD PPARD

CTD Gene:5467 PPARD

dbSNP Gene:5467 PPARD

ENSEMBL:ENSG00000112033 PPARD

ENSEMBL:ENSG00000112033.14 PPARD

HGNC:9235 PPARD

KEGG Gene (Homo sapiens):5467 PPARD

Monarch:5467 PPARD

NCBI Gene:5467 PPARD

OMIM:600409 PPARD

UCSC:Q03181 PPARD

Reference Transcript

Other Identifiers

11725170_a_at

11725171_at

11735395_at

17007810

208044_3p_s_at

208044_PM_s_at

208044_s_at

210636_3p_at

210636_PM_at

210636_at

2904598

2904599

2904600

2904604

2904620

2904625

2904626

2904627

2904634

2904637

2904640

2904642

2904643

2904644

2904645

2904646

2904647

2904648

2904649

2904650

2904652

37152_PM_at

37152_at

5467

8118945

91954_s_at

91956_r_at

A_23_P214681

A_24_P252130

GE56066

GE592698

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001223

GO:0001227

GO:0001890

GO:0003013

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005504

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005975

GO:0006006

GO:0006029

GO:0006091

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0006635

GO:0006915

GO:0006954

GO:0007154

GO:0007155

GO:0007507

GO:0007566

GO:0008203

GO:0008270

GO:0008283

GO:0008289

GO:0008366

GO:0008654

GO:0009062

GO:0009749

GO:0009755

GO:0010033

GO:0010628

GO:0012501

GO:0014065

GO:0014068

GO:0014823

GO:0014842

GO:0014912

GO:0015908

GO:0019216

GO:0019395

GO:0022414

GO:0023052

GO:0030154

GO:0030308

GO:0030522

GO:0031589

GO:0031669

GO:0032966

GO:0033189

GO:0035774

GO:0042060

GO:0042127

GO:0042311

GO:0043066

GO:0043226

GO:0043401

GO:0043415

GO:0043565

GO:0043616

GO:0045598

GO:0045600

GO:0045662

GO:0045684

GO:0045892

GO:0045893

GO:0045944

GO:0046321

GO:0046697

GO:0046872

GO:0048662

GO:0048856

GO:0048870

GO:0050673

GO:0050678

GO:0050680

GO:0050728

GO:0051059

GO:0051546

GO:0051716

GO:0055085

GO:0060089

GO:0060612

GO:0070341

GO:0070346

GO:0070539

GO:0071222

GO:0071456

GO:0097009

GO:0097190

GO:0140110

GO:0140297

GO:1901135

GO:1902894

GO:1904659

GO:1990837

GO:2000277

GO:2000288

HMNXSV003033220

HMNXSV003041279

ILMN_1674282

ILMN_1779794

ILMN_1811973

L07592_at

PH_hs_0005922

TC06000514.hg

TC06002752.hg

g12803754_3p_at

g12803754_3p_x_at

g5453939_3p_a_at

g5453939_3p_s_at

g5453939_3p_x_at

Participates

as a member of

NR [nucleoplasm] (Homo sapiens)

as a component of

RXRA:PPARD [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of PPARD [nucleoplasm] (Caenorhabditis elegans)

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

Eip75B [nucleoplasm] (Drosophila melanogaster)

Ppard [nucleoplasm] (Mus musculus)

Ppard [nucleoplasm] (Rattus norvegicus)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

PPARD [nucleoplasm] (Bos taurus)

PPARD [nucleoplasm] (Canis familiaris)

PPARD [nucleoplasm] (Gallus gallus)

PPARD [nucleoplasm] (Sus scrofa)

wu:fk47c06 [nucleoplasm] (Danio rerio)

ppard [nucleoplasm] (Xenopus tropicalis)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

unc-55 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011513012.1, NP_006229.1, NP_001165291.1, XP_016866460.1, NP_803184.1, XP_016866463.1, XP_016866461.1, XP_005249250.1, XP_006715183.1, XP_016866462.1, NP_001165290.1, NP_001165289.1, XP_011513009.1, XP_006715186.1, XP_011513011.1

ZINC - World Drugs

PPARD_HUMAN

Guide to Pharmacology - Targets

594

OpenTargets

ENSG00000112033

ZINC - FDA approved

PPARD_HUMAN

ZINC - Substances

PPARD_HUMAN

ZINC - Biogenic

PPARD_HUMAN

ZINC target

Q03181

PRO

Q03181

PDB

2Q5G, 3GWX, 7F80, 2ZNQ, 5U46, 3ET2, 2ZNP, 3SP9, 2ENV, 3PEQ, 2B50, 5U3R, 5Y7X, 5U3S, 5U40, 2AWH, 1Y0S, 5U41, 5U3T, 5U42, 5U3U, 3TKM, 5U43, 5U3V, 7WGL, 3OZ0, 3GZ9, 5U3W, 2XYX, 7VWF, 7WGN, 2XYW, 7VWE, 6A6P, 5U3X, 3D5F, 5U3Q, 5U3Y, 7VWH, 5ZXI, 7VWG, 5U3Z, 2XYJ, 2J14, 2BAW, 7W0G, 2GWX, 5XMX, 1GWX, 3DY6, 5U45, 5U44

ZINC - Investigational

PPARD_HUMAN

ZINC - Metabolites

PPARD_HUMAN

HPA

ENSG00000112033-PPARD

GeneCards

Q03181

Ensembl

ENSG00000112033, ENSP00000337063, ENST00000360694, ENSP00000413314, ENST00000337400, ENSP00000414372, ENST00000418635, ENSP00000310928, ENST00000311565, ENSP00000353916, ENST00000448077

Pharos - Targets

Q03181

ZINC - Predictions - Purchasable

PPARD_HUMAN

HMDB Protein

HMDBP02359

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2