Reactome | p-Y1022,Y1023-JAK1 [cytosol]

p-Y1022,Y1023-JAK1 [cytosol]

Stable Identifier

R-HSA-9005335

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
19535621	Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease Bamba, S, Kim-Mitsuyama, S, Andoh, A, Fujiyama, Y, Nishida, A, Tsujikawa, T, Shioya, M	J. Immunol.	2009

External Reference Information

External Reference

UniProt:P23458 JAK1

Gene Names

JAK1, JAK1A, JAK1B

Chain

chain:1-1154

Reference Genes

BioGPS Gene:3716 JAK1

COSMIC (genes):JAK1 JAK1

CTD Gene:3716 JAK1

dbSNP Gene:3716 JAK1

ENSEMBL:ENSG00000162434 JAK1

HGNC:6190 JAK1

KEGG Gene (Homo sapiens):3716 JAK1

Monarch:3716 JAK1

NCBI Gene:3716 JAK1

OMIM:147795 JAK1

UCSC:P23458 JAK1

Reference Transcript

Other Identifiers

0006590292

11717685_at

11717686_a_at

11717687_a_at

1457_at

1552610_a_at

1552611_a_at

16688164

16688214

201648_at

2416521

2416523

2416524

2416525

2416526

2416528

2416529

2416530

2416531

2416532

2416534

2416535

2416536

2416537

2416541

2416542

2416544

2416545

2416549

2416553

2416556

2416558

2416559

2416561

2416566

2416568

2416569

2416570

2416593

2416594

2416595

2416709

2416711

34877_at

3716

41594_at

7916747

A_21_P0001139

A_23_P97005

A_24_P410678

A_33_P3784283

GE58033

GO:0000165

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0004715

GO:0005131

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005768

GO:0005829

GO:0005856

GO:0005925

GO:0006464

GO:0006468

GO:0006950

GO:0007155

GO:0007165

GO:0008150

GO:0012505

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0019899

GO:0019903

GO:0031410

GO:0031625

GO:0031730

GO:0034112

GO:0035556

GO:0035722

GO:0035723

GO:0038110

GO:0038111

GO:0038113

GO:0038114

GO:0043167

GO:0043226

GO:0046677

GO:0046872

GO:0048646

GO:0048856

GO:0060333

GO:0060334

GO:0060337

GO:0070102

GO:0070106

GO:0070757

GO:0150105

GO:1903672

HMNXSV003011048

HMNXSV003020647

Hs.50651.0.S2_3p_at

Hs2.50651.1.S1_3p_s_at

Hs2.50651.1.S2_3p_s_at

ILMN_1793384

M64174_at

PH_hs_0025462

TC01002741.hg

TC01002747.hg

TC01005542.hg

Participates

as a component of

IL20RA:p-Y1022,Y1023-JAK1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

JAK1 [endosome]

p-JAK1 [cytosol]

p-Y1034-JAK1 [cytosol]

JAK1 [cytosol]

p-Y-JAK1 [cytosol]

Inferred To

phospho-jak1 [cytosol] (Danio rerio)

phospho-jak1 [cytosol] (Xenopus tropicalis)

phospho-JAK1 [cytosol] (Bos taurus)

phospho-JAK1 [cytosol] (Canis familiaris)

phospho-JAK1 [cytosol] (Gallus gallus)

phospho-JAK1 [cytosol] (Sus scrofa)

phospho-Jak1 [cytosol] (Mus musculus)

phospho-Jak1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1022

Coordinate

1022

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1023

Coordinate

1023

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001307852.1, NP_001308785.1, NP_001308784.1, NP_001308783.1, NP_002218.2, NP_001308782.1, NP_001308781.1

ZINC - World Drugs

JAK1_HUMAN

Guide to Pharmacology - Targets

2047

OpenTargets

ENSG00000162434

ZINC - FDA approved

JAK1_HUMAN

ZINC - Substances

JAK1_HUMAN

ZINC - Biogenic

JAK1_HUMAN

ZINC target

P23458

PRO

P23458

GlyGen

P23458

PDB

6HZU, 6N79, 4IVC, 5KHW, 6ELR, 5KHX, 5E1E, 6AAH, 4IVD, 6RSH, 4I5C, 6SMB, 6BBU, 4IVB, 6DBN, 4GS0, 5HX8, 6RSE, 6GGH, 6SM8, 4E5W, 6TPF, 6C7Y, 6W8L, 5WO4, 5IXI, 5L04, 3EYH, 4FK6, 4K6Z, 4K77, 5IXD, 6N77, 4E4L, 4L01, 6N78, 4E4N, 4EI4, 3EYG, 4EHZ, 6TPE, 6N7D, 6RSD, 6N7C, 4L00, 6RSB, 6N7A, 6N7B, 6RSC

ZINC - Investigational

JAK1_HUMAN

GeneCards

P23458

HPA

ENSG00000162434-JAK1

Ensembl

ENSP00000500485, ENSP00000343204, ENSP00000500296, ENSP00000499900, ENST00000671929, ENSP00000499884, ENST00000671954, ENST00000672247, ENST00000672179, ENST00000342505, ENSG00000162434, ENST00000672434, ENSP00000500841

Pharos - Targets

P23458

ZINC - Predictions - Purchasable

JAK1_HUMAN

HMDB Protein

HMDBP01309

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42224 STAT1	7	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.757	6
UniProt:P48551 IFNAR2			0.591	3
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.564	2
UniProt:P40189-1 IL6ST	1	p-5Y-IL6ST-1 [plasma membrane] (R-HSA-1112580)	0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.502	2
UniProt:O60674 JAK2	8	p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327) p-JAK2 [cytosol] (R-HSA-210621) p-Y813-JAK2 [cytosol] (R-HSA-997248) JAK2 V617F [nucleoplasm] (R-HSA-5211269) JAK2 [endosome lumen] (R-HSA-2002372) p-12Y-JAK2 [cytosol] (R-HSA-2586516) p-Y1007-JAK2 [cytosol] (R-HSA-873799) JAK2 [cytosol] (R-HSA-210620)	0.463	4

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