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RAF1 [cytosol]
Stable Identifier
R-MMU-167205
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q99N57
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GP1b-IX-V activation signalling (Mus musculus)
14-3-3-zeta binds Raf1 (Mus musculus)
14-3-3-zeta:Raf1 [cytosol] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
c-Src binds Raf1 (Mus musculus)
Active c-Src:Raf1 [cytosol] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Rap1 signalling (Mus musculus)
Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)
RAF1 [cytosol] (Mus musculus)
Rap1-GTP:Raf1 [plasma membrane] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Interferon gamma signaling (Mus musculus)
IFNG signaling activates MAPKs (Mus musculus)
Activated JAK1 binds RAF1 (Mus musculus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
JAK1-mediated phosphorylation of RAF1 (Mus musculus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CD209 (DC-SIGN) signaling (Mus musculus)
PAK phosphorylates p21 RAF1 on S338 (Mus musculus)
p21 RAS:GTP:RAF1 [plasma membrane] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
RAF1 binds p21 RAS:GTP (Mus musculus)
RAF1 [cytosol] (Mus musculus)
p21 RAS:GTP:RAF1 [plasma membrane] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Stimuli-sensing channels (Mus musculus)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Mus musculus)
RAF1:SGK:TSC22D3:WPP [cytosol] (Mus musculus)
RAF1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q99N57
Reference Genes
BioGPS Gene:110157
ENSEMBL:ENSMUSG00000000441
KEGG Gene (Mus musculus):110157
Monarch:110157
NCBI Gene:110157
UCSC:Q99N57
Reference Transcript
RefSeq:XM_006505363.3
RefSeq:XM_006505365.2
RefSeq:NM_029780.3
RefSeq:XM_006505364.2
Other Identifiers
10547034
110157
140282_f_at
1416078_s_at
1425419_a_at
17469894
4364488
4382407
4405510
4552942
4574845
4598310
4599262
4629137
4853093
4881848
4949521
4961361
5098067
5133730
5139630
5157830
5223962
5229250
5241129
5267873
5307983
5367810
5563343
5584314
5599575
5616693
94264_at
A_51_P404204
A_52_P214058
A_52_P412600
A_55_P1973643
GE125263
GO:0000165
GO:0000166
GO:0001666
GO:0001678
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007165
GO:0007190
GO:0008179
GO:0008285
GO:0008286
GO:0008625
GO:0010856
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0031434
GO:0033138
GO:0035019
GO:0035556
GO:0035773
GO:0035994
GO:0036211
GO:0042802
GO:0043066
GO:0043226
GO:0043410
GO:0044342
GO:0044877
GO:0045104
GO:0045944
GO:0046872
GO:0048009
GO:0048011
GO:0048538
GO:0048856
GO:0060324
GO:0065003
GO:0071550
GO:0098772
GO:0106310
GO:0140096
GO:1902042
ILMN_2747229
Msa.24413.0_s_at
Msa.6334.0_s_at
mMC010690
Participates
as an input of
Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)
c-Src binds Raf1 (Mus musculus)
14-3-3-zeta binds Raf1 (Mus musculus)
RAF1 binds p21 RAS:GTP (Mus musculus)
Activated JAK1 binds RAF1 (Mus musculus)
as a component of
Rap1-GTP:Raf1 [plasma membrane] (Mus musculus)
Active c-Src:Raf1 [cytosol] (Mus musculus)
14-3-3-zeta:Raf1 [cytosol] (Mus musculus)
RAF1:SGK:TSC22D3:WPP [cytosol] (Mus musculus)
p21 RAS:GTP:RAF1 [plasma membrane] (Mus musculus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S621-RAF1 [cytosol]
phospho-p-Y-RAF1 [cytosol]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S621-RAF1 [plasma membrane]
phospho-hyperphosphorylated RAF1 [plasma membrane]
phospho-p-S259,S621-RAF1 [cytosol]
phospho-p-S338-RAF1 [cytosol]
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
Inferred From
RAF1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006505426.1
,
XP_006505428.1
,
NP_084056.1
,
XP_006505427.1
Ensembl
ENSMUSP00000000451
,
ENSMUSG00000000441
,
ENSMUSP00000108571
,
ENSMUST00000112949
,
ENSMUST00000000451
PRO
Q99N57
MGI
97847
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28028
6
phospho-p-S365,S446,S729 BRAF [cytosol]
(R-MMU-5672667)
phospho-hyperphosphorylated BRAF [plasma membrane]
(R-MMU-5675199)
BRAF [cytosol]
(R-MMU-167224)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]
(R-MMU-5672679)
phospho-p-S446,S729-BRAF [cytosol]
(R-MMU-5672673)
phospho-p-S446,T599,S602,S729 BRAF [cytosol]
(R-MMU-5672676)
0.589
2
UniProt:Q8CFI0
2
Nedd4l [cytosol]
(R-MMU-976003)
Nedd4l [nucleoplasm]
(R-MMU-2176420)
0.524
2
UniProt:Q9Z2S7-3 TSC22D3
0.524
2
UniProt:P01111 NRAS
20
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
NRAS [plasma membrane]
(R-HSA-62725)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
0.499
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.499
3
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
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