Reactome | SEMA4F [plasma membrane]

SEMA4F [plasma membrane]

Stable Identifier

R-HSA-3006460

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Semaphorin-4F, SEM4F_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RND3 GTPase cycle (Homo sapiens)
        
        RND3 binds effectors (Homo sapiens)
        
        RND3 effectors [cytosol] (Homo sapiens)
        
        SEMA4F [plasma membrane] (Homo sapiens)
        
        RND3:GTP:RND3 effectors [plasma membrane] (Homo sapiens)
        
        RND3 effectors [cytosol] (Homo sapiens)
        
        SEMA4F [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95754 SEMA4F

Gene Names

SEMA4F, SEMAM, SEMAW

Chain

signal peptide:1-34, chain:35-770

Reference Genes

BioGPS Gene:10505 SEMA4F

COSMIC (genes):SEMA4F SEMA4F

CTD Gene:10505 SEMA4F

dbSNP Gene:10505 SEMA4F

ENSEMBL:ENSG00000135622 SEMA4F

HGNC:10734 SEMA4F

KEGG:hsa:10505 SEMA4F

Monarch:10505 SEMA4F

NCBI Entrez Gene:10505 SEMA4F

OMIM:603706 SEMA4F

UCSC:O95754 SEMA4F

Reference Transcript

Other Identifiers

10505

11722440_a_at

11722441_a_at

11748626_a_at

16881818

208124_PM_s_at

208124_s_at

210124_PM_x_at

210124_x_at

228660_PM_x_at

228660_x_at

2489471

2489472

2489473

2489476

2489478

2489480

2489481

2489482

2489484

2489485

2489486

2489487

2489488

2489489

2489490

2489491

2489492

2489494

2489495

2489496

2489497

2489498

2489499

2489500

2489501

2489502

2489503

39574_at

42543_at

50811_at

8042925

A_23_P165608

A_32_P195065

GE53586

GO:0001755

GO:0005515

GO:0005783

GO:0005886

GO:0007267

GO:0007399

GO:0007411

GO:0014069

GO:0016020

GO:0030154

GO:0030215

GO:0030335

GO:0030425

GO:0030517

GO:0031290

GO:0038191

GO:0042995

GO:0043204

GO:0043226

GO:0045202

GO:0045211

GO:0045499

GO:0048856

GO:0048870

GO:0050919

GO:0071526

GO:0098839

GO:0098978

HMNXSV003010457

Hs.117612.1.A1_3p_s_at

ILMN_1805007

PH_hs_0002276

TC02000465.hg

g13276610_3p_s_at

g4759093_3p_a_at

Participates

as a candidate of

RND3 effectors [cytosol] (Homo sapiens)

Inferred To

Sema4f [plasma membrane] (Mus musculus)

Sema4f [plasma membrane] (Rattus norvegicus)

SEMA4F [plasma membrane] (Bos taurus)

SEMA4F [plasma membrane] (Canis familiaris)

SEMA4F [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001258591.1, NP_001258590.1, NP_004254.2

ENSEMBL

ENSP00000342675, ENSG00000135622, ENST00000339773, ENSP00000350547, ENST00000357877

OpenTargets

ENSG00000135622

GeneCards

SEMA4F

HPA

ENSG00000135622-SEMA4F

PRO

O95754

Pharos - Targets

O95754

GlyGen

O95754

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.553	5
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2

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