Reactome | GATAD2B [nucleoplasm]

GATAD2B [nucleoplasm]

Stable Identifier

R-HSA-3702079

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional repressor p66-beta, P66B_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2B [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2B [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2B [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2B [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2B [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)
        
        GATAD2B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WXI9 GATAD2B

Gene Names

GATAD2B, KIAA1150

Chain

chain:1-593

Reference Genes

BioGPS Gene:57459 GATAD2B

COSMIC (genes):GATAD2B GATAD2B

CTD Gene:57459 GATAD2B

dbSNP Gene:57459 GATAD2B

ENSEMBL:ENSG00000143614 GATAD2B

HGNC:30778 GATAD2B

KEGG:hsa:57459 GATAD2B

Monarch:57459 GATAD2B

NCBI Gene:57459 GATAD2B

OMIM:614998 GATAD2B

UCSC:Q8WXI9 GATAD2B

Reference Transcript

Other Identifiers

11724893_at

11724894_at

11724895_at

16693546

225393_PM_at

225393_at

238076_PM_at

238076_at

2436227

2436229

2436230

2436231

2436232

2436233

2436234

2436236

2436237

2436238

2436239

2436240

2436241

2436242

2436243

2436244

2436245

2436247

2436248

2436269

2436274

2436275

2436276

2436277

46443_at

57459

64410_at

68606_at

7920341

A_19_P00324786

A_23_P386509

A_33_P3323822

GE53798

GO:0000122

GO:0000781

GO:0000785

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0006355

GO:0008270

GO:0016581

GO:0016607

GO:0031492

GO:0032991

GO:0042659

GO:0043226

GO:0043565

GO:0045892

GO:0045893

GO:0046872

GO:2000736

HMNXSV003023369

Hs.44772.0.A1_3p_at

Hs.4779.1.A1_3p_at

ILMN_1766359

PH_hs_0000486

TC01003278.hg

Participates

as a candidate of

(GATAD2A, GATAD2B) [nucleoplasm] (Homo sapiens)

Inferred To

dcp-66 [nucleoplasm] (Caenorhabditis elegans)

gatad2b [nucleoplasm] (Xenopus tropicalis)

Gatad2b [nucleoplasm] (Mus musculus)

Gatad2b [nucleoplasm] (Rattus norvegicus)

GATAD2B [nucleoplasm] (Bos taurus)

GATAD2B [nucleoplasm] (Canis familiaris)

GATAD2B [nucleoplasm] (Gallus gallus)

GATAD2B [nucleoplasm] (Sus scrofa)

simj [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_005245421.1, NP_065750.1

ENSEMBL

ENST00000576342, ENSP00000489184, ENST00000634544, ENSP00000458280, ENST00000368655, ENSP00000357644

OpenTargets

ENSG00000143614

HPA

ENSG00000143614-GATAD2B

PRO

Q8WXI9

Pharos - Targets

Q8WXI9

GlyGen

Q8WXI9

Orphanet

GATAD2B

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.877	10
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.837	7
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	7
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.725	6
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.666	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.527	2
UniProt:Q15274 QPRT	1	QPRT [cytosol] (R-HSA-197212)	0.527	2
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.527	4
UniProt:Q9H3M7 TXNIP	2	TXNIP [cytosol] (R-HSA-1250246) TXNIP [nucleoplasm] (R-HSA-9617747)	0.527	2
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.527	4
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	5
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.527	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.527	5

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