Reactome | SUFU [ciliary base]

SUFU [ciliary base]

Stable Identifier

R-HSA-5610424

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary base

Synonyms

Suppressor of fused homolog, SUFU_HUMAN

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UMX1 SUFU

Gene Names

SUFU, UNQ650/PRO1280

Chain

chain:1-484

Reference Genes

BioGPS Gene:51684 SUFU

COSMIC (genes):SUFU SUFU

CTD Gene:51684 SUFU

dbSNP Gene:51684 SUFU

ENSEMBL:ENSG00000107882 SUFU

ENSEMBL_homo_sapiens_GENE:ENSG00000107882.12 SUFU

HGNC:16466 SUFU

KEGG Gene (Homo sapiens):51684 SUFU

Monarch:51684 SUFU

NCBI Gene:51684 SUFU

OMIM:607035 SUFU

UCSC:Q9UMX1 SUFU

Reference Transcript

Other Identifiers

11721036_at

11721037_a_at

11721038_at

11744963_a_at

11759802_at

11762006_at

16708699

222749_PM_at

222749_at

224201_PM_s_at

224201_s_at

224202_PM_at

224202_at

224203_PM_at

224203_at

3261766

3261767

3261770

3261776

3261786

3261787

3261788

3261789

3261790

3261795

3261796

3261797

3261798

3261799

3261800

3261801

3261802

3261803

3261807

3261809

3261810

3261811

3261819

3261821

3261822

3261823

49463_at

51684

7930120

A_14_P117713

A_14_P120695

A_23_P425304

A_24_P149893

A_24_P149902

A_33_P3333030

GE56721

GE82086

GE83749

GO:0000122

GO:0001843

GO:0001947

GO:0003281

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005929

GO:0006351

GO:0006355

GO:0006886

GO:0006913

GO:0007165

GO:0007224

GO:0007286

GO:0007368

GO:0008013

GO:0008134

GO:0019901

GO:0021513

GO:0021775

GO:0021776

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0035904

GO:0042308

GO:0043226

GO:0043433

GO:0043588

GO:0045668

GO:0045879

GO:0048856

GO:0060976

GO:0097542

GO:0097546

GO:0140110

GO:1990788

GO:2000059

GO:2001040

HMNXSV003025724

HMNXSV003031669

ILMN_1804361

PH_hs_0001856

TC10000759.hg

g6689887_3p_at

g6689893_3p_at

g7025391_3p_at

Participates

as a component of

Other forms of this molecule

SUFU [cytosol]

SUFU [ciliary tip]

Inferred To

Su(fu) [ciliary base] (Drosophila melanogaster)

Sufu [ciliary base] (Mus musculus)

Sufu [ciliary base] (Rattus norvegicus)

SUFU [ciliary base] (Bos taurus)

SUFU [ciliary base] (Canis familiaris)

SUFU [ciliary base] (Gallus gallus)

SUFU [ciliary base] (Sus scrofa)

sufu [ciliary base] (Danio rerio)

sufu [ciliary base] (Xenopus tropicalis)

Cross References

RefSeq

NP_001171604.1, NP_057253.2

OpenTargets

ENSG00000107882

GeneCards

Q9UMX1

HPA

ENSG00000107882-SUFU

Ensembl

ENSP00000358915, ENSG00000107882, ENST00000369902, ENSP00000411597, ENST00000369899, ENSP00000358918, ENST00000423559

PRO

Q9UMX1

Pharos - Targets

Q9UMX1

Orphanet

15569

PDB

4BLD, 4BL8, 1M1L, 4BL9, 4KMD, 4KMH, 4BLB, 4BLA, 4KM9, 4KM8

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08151 GLI1	9	ub-GLI1 [cytosol] (R-HSA-5635833) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) pS-GLI1 [ciliary base] (R-HSA-5610497) GLI1 [cytosol] (R-HSA-445457) p-GLI1 [ciliary tip] (R-HSA-5635040) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [nucleoplasm] (R-HSA-5635042) GLI1 [ciliary tip] (R-HSA-5610360) GLI1 [ciliary base] (R-HSA-5610357)	0.968	27
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.848	8
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.847	9
UniProt:P10071 GLI3	13	ub-2p-GLI3 [nucleoplasm] (R-HSA-5635060) GLI3 [cytosol] (R-HSA-206085) p-GLI3 [ciliary tip] (R-HSA-5635048) 2p-GLI3 [nucleoplasm] (R-HSA-5635052) p-GLI3 [nucleoplasm] (R-HSA-5635051) GLI3 [ciliary tip] (R-HSA-5610367) GLI3R [nucleoplasm] (R-HSA-5610371) GLI3R [cytosol] (R-HSA-5610369) ub-p13S-GLI3 [ciliary base] (R-HSA-5610506) p13S-GLI3 [ciliary base] (R-HSA-5610485) p10S-GLI3 [ciliary base] (R-HSA-5610454) p6S-GLI3 [ciliary base] (R-HSA-5610492) GLI3 [ciliary base] (R-HSA-5610365)	0.773	5
UniProt:Q13515 BFSP2			0.742	6
UniProt:Q96D15 RCN3			0.703	5
UniProt:Q8TBC5 ZSC18			0.666	4
UniProt:Q7Z353 HDX			0.666	4
UniProt:Q9NWS9-2 ZNF446			0.666	4
UniProt:Q86YD7 F90A1			0.643	3
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.643	3
UniProt:O14753 OVOL1			0.641	3
UniProt:P10070 GLI2	11	ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059) p4S-GLI2 [ciliary base] (R-HSA-5610487) p8S-GLI2 [ciliary base] (R-HSA-5610494) p11S-GLI2 [ciliary base] (R-HSA-5610471) GLI2 [ciliary tip] (R-HSA-5610363) GLI2 [ciliary base] (R-HSA-5610361) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501)	0.569	3
UniProt:Q12968 NFATC3	3	p-S265-NFATC3 [cytosol] (R-HSA-2685614) p-S265-NFATC3 [nucleoplasm] (R-HSA-2025988) p-13S-NFATC3 [cytosol] (R-HSA-2025920)	0.564	2
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q8NC26 ZNF114	1	ZNF114 [nucleoplasm] (R-HSA-975026)	0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:Q9Y3S2 ZN330			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q53ET0 CRTC2	1	CRTC2 [nucleoplasm] (R-HSA-8931951)	0.556	5
UniProt:Q8N4C7 STX19			0.556	3
UniProt:Q0D2J5 ZN763			0.556	3
UniProt:Q86VQ0 LCA5			0.556	3
UniProt:Q9P2A4 ABI3			0.556	3
UniProt:Q9UJ55 MAGL2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:Q96GZ6 S41A3			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.553	2
UniProt:Q8NEA6 GLIS3			0.553	3
UniProt:Q9NPA3 MID1IP1	1	MID1IP1 [cytosol] (R-HSA-8867328)	0.547	3
UniProt:Q9NRP7 STK36			0.536	3
UniProt:P12644 BMP4	4	BMP4 [extracellular region] (R-HSA-8858573) BMP4 [endoplasmic reticulum lumen] (R-HSA-8956775) p-BMP4 [endoplasmic reticulum lumen] (R-HSA-8956944) BMP4(20-408) [extracellular region] (R-HSA-2396280)	0.527	3
UniProt:Q7Z6J8 UBE3D	1	UBE3D [cytosol] (R-HSA-8851647)	0.527	2
UniProt:P30837 ALDH1B1	1	ALDH1B1 [mitochondrial matrix] (R-HSA-5696097)	0.527	2
UniProt:O14771 ZNF213	1	ZNF213 [nucleoplasm] (R-HSA-1027351)	0.527	3
UniProt:Q92611 EDEM1	1	EDEM1 [endoplasmic reticulum quality control compartment] (R-HSA-381083)	0.527	2
UniProt:Q1X8D7 LRC36			0.527	2
UniProt:O60293 ZC3H1			0.527	3
UniProt:Q9Y466 NR2E1	1	NR2E1 [nucleoplasm] (R-HSA-376207)	0.527	2
UniProt:O95157 NXPH3			0.527	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.527	2
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.527	3
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.508	2
UniProt:Q0VGT2 Gli2	13	phospho-Gli2 [nucleoplasm] (R-MMU-5635059) ub-p11S-Gli2 [cytosol] (R-MMU-5610503) p11S-Gli2 [cytosol] (R-MMU-5610476) p8S-Gli2 [cytosol] (R-MMU-5610496) p4S-Gli2 [cytosol] (R-MMU-5610489) Gli2 [cytosol] (R-MMU-5610376) Gli2 [nucleoplasm] (R-MMU-3900178) Gli2 [cytosol] (R-MMU-445451) phospho-Gli2 [ciliary tip] (R-MMU-5635044) phospho-Gli2 [nucleoplasm] (R-MMU-5635047) phospho-Gli2 [nucleoplasm] (R-MMU-5635055) Gli2 [ciliary base] (R-MMU-5610361) Gli2 [ciliary tip] (R-MMU-5610363)	0.463	3

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