Reactome | ub-KEAP1 [cytosol]

ub-KEAP1 [cytosol]

Stable Identifier

R-HSA-9766647

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)
        
        SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1 [cytosol] (Homo sapiens)
      - MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)
        
        MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
        
        SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1 [cytosol] (Homo sapiens)
        
        SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1 [cytosol] (Homo sapiens)
      - RBX1:CUL3 dissociates from forming autophagosome (Homo sapiens)
        
        MAP1LC3B:SESN1,2:ub K420 p-S349 SQSTM1 oligomer:ub-KEAP1 [cytosol] (Homo sapiens)
        
        ub-KEAP1 [cytosol] (Homo sapiens)
        
        MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
        
        SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
        
        ub-KEAP1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
15983046	Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway Sun, Z, Zhang, DD, Hannink, M, Lieberman, MW, Habib, GM, Lo, SC	J Biol Chem	2005

External Reference Information

External Reference

UniProt:Q14145 KEAP1

Gene Names

KEAP1, INRF2, KIAA0132, KLHL19

Chain

chain:1-624

Reference Genes

BioGPS Gene:9817 KEAP1

COSMIC (genes):KEAP1 KEAP1

CTD Gene:9817 KEAP1

dbSNP Gene:9817 KEAP1

ENSEMBL:ENSG00000079999.14 KEAP1

HGNC:23177 KEAP1

KEGG Gene (Homo sapiens):9817 KEAP1

Monarch:9817 KEAP1

NCBI Gene:9817 KEAP1

OMIM:606016 KEAP1

UCSC:Q14145 KEAP1

Reference Transcript

Other Identifiers

0001340520

0006840484

11716444_a_at

16868743

202417_PM_at

202417_at

35322_at

3850364

3850365

3850366

3850367

3850369

3850370

3850371

3850372

3850373

3850374

3850376

3850377

3850378

3850379

3850381

8034034

9817

A_23_P119141

D50922_at

GE57257

GO:0001701

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0006351

GO:0006355

GO:0006511

GO:0006914

GO:0010506

GO:0016234

GO:0016567

GO:0030154

GO:0030163

GO:0030496

GO:0031463

GO:0032436

GO:0032991

GO:0034451

GO:0034599

GO:0036211

GO:0042802

GO:0042994

GO:0043226

GO:0043433

GO:0045604

GO:0048856

GO:0061629

GO:0071353

GO:0097718

HMNXSV003035494

ILMN_1711787

ILMN_1775920

ILMN_2410771

ILMN_2410772

PH_hs_0003698

TC19001166.hg

g6912451_3p_at

Participates

as a component of

Other forms of this molecule

Ub-KEAP1 [cytosol]

KEAP1 [cytosol]

Inferred To

ub-KEAP1 [cytosol] (Canis familiaris)

ub-KEAP1 [cytosol] (Dictyostelium discoideum)

Ghost homologue of ub-KEAP1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of ub-KEAP1 [cytosol] (Gallus gallus)

keap1 [cytosol] (Xenopus tropicalis)

Keap1 [cytosol] (Drosophila melanogaster)

Keap1 [cytosol] (Mus musculus)

Keap1 [cytosol] (Rattus norvegicus)

KEAP1 [cytosol] (Bos taurus)

KEAP1 [cytosol] (Sus scrofa)

keap1b [cytosol] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position

Modification

K48-linked polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_005260230.1, XP_005260231.1, NP_036421.2, NP_987096.1, XP_011526754.1

Guide to Pharmacology - Targets

2757

OpenTargets

ENSG00000079999

HPA

ENSG00000079999-KEAP1

ZINC - Substances

KEAP1_HUMAN

GeneCards

Q14145

ZINC target

Q14145

Ensembl

ENST00000393623, ENST00000171111, ENSG00000079999, ENSP00000377245, ENSP00000171111

PRO

Q14145

Pharos - Targets

Q14145

ZINC - Predictions - Purchasable

KEAP1_HUMAN

PDB

5WIY, 7K2F, 5GIT, 4L7C, 7K2O, 4L7B, 6FMP, 6WCQ, 4CXJ, 7K2P, 7Q96, 7K2G, 7K2D, 6SP1, 6FFM, 7Q6Q, 7K2N, 4L7D, 4XMB, 4CXT, 7Q8R, 3ZGD, 6TG8, 3ZGC, 7Q6S, 6ROG, 6T7Z, 4IN4, 7K2K, 4IQK, 7EXI, 7K29, 5DAF, 6HWS, 7K2I, 7K2H, 6FMQ, 4IFN, 5NLB, 6T7V, 7K2J, 4IFL, 7K2A, 7Q5H, 6LRZ, 6TYM, 5WFV, 5WHL, 5WG1, 7K28, 6W66, 6TYP, 6W67, 1ZGK, 3VNG, 6Z6A, 7K2M, 7K2L, 7K2E, 5WFL, 5X54, 6SP4, 7K2S, 6V6Z, 6UF0, 7K2B, 4IFJ, 3VNH, 1U6D, 7K2C, 4N1B, 7K2Q, 5WHO, 6W68, 5F72, 4CXI, 6W69, 2FLU, 7K2R, 5DAD

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	12	p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) ub-NFE2L2 [cytosol] (R-HSA-9758077) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.972	34
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.963	19
UniProt:P62495 ETF1	2	Me-Q185-ETF1 [cytosol] (R-HSA-6800157) ETF1 [cytosol] (R-HSA-54433)	0.834	8
UniProt:Q9NY33 DPP3	1	DPP3 [cytosol] (R-HSA-9795741)	0.834	8
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.834	8
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.742	5
UniProt:Q9Y2D1 ATF5	1	ATF5 [nucleoplasm] (R-HSA-9653719)	0.611	3
UniProt:Q13153 PAK1	6	Active PAK1 [cytosol] (R-HSA-8964622) p-S144-PAK1 [cytosol] (R-HSA-451339) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.611	5
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.61	6
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.592	4
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.556	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.556	3
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.556	3
UniProt:Q15149 PLEC	3	PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575)	0.544	4
UniProt:O95997 PTTG1	2	K11polyUb-PTTG1 [cytosol] (R-HSA-3095943) PTTG1 [cytosol] (R-HSA-174190)	0.544	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.527	2
UniProt:O88351	2	phospho-p-S177,S181-IKBKB [cytosol] (R-MMU-202506) IKBKB [cytosol] (R-MMU-168114)	0.508	2
UniProt:Q5JTC6 AMER1	5	AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.499	2

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