Reactome | ATG14 [phagophore assembly site membrane]

ATG14 [phagophore assembly site membrane]

Stable Identifier

R-HSA-5682389

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagophore assembly site membrane

Synonyms

Beclin 1-associated autophagy-related key regulator, BAKOR_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q6ZNE5 ATG14

Gene Names

ATG14, ATG14L, KIAA0831

Chain

chain:1-492

Reference Genes

BioGPS Gene:22863 ATG14

COSMIC (genes):ATG14 ATG14

CTD Gene:22863 ATG14

dbSNP Gene:22863 ATG14

ENSEMBL:ENSG00000126775 ATG14

HGNC:19962 ATG14

KEGG:hsa:22863 ATG14

Monarch:22863 ATG14

NCBI Gene:22863 ATG14

OMIM:613515 ATG14

UCSC:Q6ZNE5 ATG14

Reference Transcript

Other Identifiers

11725487_at

11725488_a_at

11725489_x_at

11725490_s_at

16793263

204568_PM_at

204568_at

22863

3565740

3565741

3565742

3565743

3565744

3565745

3565746

3565749

3565750

3565753

3565756

3565757

3565758

3565759

3565762

3565763

3565767

3565768

3565775

41372_at

7979328

A_23_P309989

GE53529

GO:0000045

GO:0000407

GO:0000421

GO:0000423

GO:0001933

GO:0001934

GO:0002376

GO:0005515

GO:0005737

GO:0005773

GO:0005776

GO:0005783

GO:0005789

GO:0005829

GO:0005930

GO:0006622

GO:0006629

GO:0006886

GO:0006914

GO:0007005

GO:0008333

GO:0009267

GO:0010608

GO:0016020

GO:0016192

GO:0016236

GO:0016240

GO:0016241

GO:0031410

GO:0032991

GO:0034045

GO:0035014

GO:0035032

GO:0036092

GO:0042149

GO:0043226

GO:0043491

GO:0043495

GO:0044233

GO:0045022

GO:0045087

GO:0045335

GO:0051020

GO:0051607

GO:0060090

GO:0061635

GO:0090207

GO:0097352

GO:0097629

GO:0097632

GO:0098542

GO:0098772

GO:0098780

GO:0141039

HMNXSV003023850

ILMN_1678808

PH_hs_0033240

TC14001159.hg

g7662325_3p_at

Participates

as a component of

ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [phagophore assembly site membrane] (Homo sapiens)

Other forms of this molecule

ATG14 [endoplasmic reticulum membrane]

ATG14 [cytosol]

Inferred To

atg14 [phagophore assembly site membrane] (Schizosaccharomyces pombe)

atg14 [phagophore assembly site membrane] (Xenopus tropicalis)

ATG14 [phagophore assembly site membrane] (Bos taurus)

ATG14 [phagophore assembly site membrane] (Canis familiaris)

ATG14 [phagophore assembly site membrane] (Gallus gallus)

ATG14 [phagophore assembly site membrane] (Sus scrofa)

epg-8 [phagophore assembly site membrane] (Caenorhabditis elegans)

Ghost homologue of ATG14 [phagophore assembly site membrane] (Dictyostelium discoideum)

Ghost homologue of ATG14 [phagophore assembly site membrane] (Saccharomyces cerevisiae)

Atg14 [phagophore assembly site membrane] (Drosophila melanogaster)

Atg14 [phagophore assembly site membrane] (Mus musculus)

Atg14 [phagophore assembly site membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_054231553.1, NP_055739.2, XP_011534865.1

ENSEMBL

ENSG00000126775, ENST00000247178, ENSP00000247178

OpenTargets

ENSG00000126775

GeneCards

ATG14

HPA

ENSG00000126775-ATG14

PRO

Q6ZNE5

Pharos - Targets

Q6ZNE5

PDB

8SOR, 9C82, 6HOL

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.979	51
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.527	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.471	2

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