p-BRAF G466A [plasma membrane]

Stable Identifier
R-HSA-9648629
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
B-RAF
p-BRAF G466A [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15035987 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Niculescu-Duvaz, D, Lee, S, Marais, R, Marshall, CJ, Barford, D, Jones, CM, Good, VM, Springer, CJ, Wan, PT, Garnett, MJ, Roe, SM

Cell 2004
28481359 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ladanyi, M, Wills, J, Rema, AB, Syed, A, Srinivasan, P, Raj, N, Mullaney, KA, Vakiani, E, Nafa, K, Shah, RH, Kundra, R, Razumova, A, Ochoa, A, Phillips, S, Jordan, EJ, Morris, LGT, Berger, MF, Thomas, SB, Camacho, N, Hellmann, MD, Hechtman, JF, Feldman, DR, Coleman, J, Mohanty, AS, Ptashkin, RN, Syed, MH, Wang, J, Saltz, LB, Reales, DN, Cheng, DT, Arcila, ME, Eubank, M, Benayed, R, Chakravarty, D, Harding, JJ, Prasad, M, Bochner, B, Durany, R, Zehir, A, Gross, BE, Zhang, H, Janjigian, YY, Iyer, G, DeLair, DF, Klimstra, DS, Robson, ME, Chen, HW, Cercek, A, Kelly, CM, Varghese, AM, Taylor, BS, Yaeger, R, Schultz, N, Hyman, DM, Won, HH, Solit, DB, Razavi, P, Chang, MT, Riely, GJ, Abeshouse, AA, Kiecka, IJ, Jayakumaran, G, Chandramohan, R, Casanova, J, Bacares, R, Abida, W, Gao, J, Soumerai, TE, Lowery, MA, Stewart, L, Ross, DS, Shukla, N, Yao, J, Al-Ahmadie, H, Penson, AV, Kim, HR, Baldi, T, Mandelker, DL, Gardos, SM, Galle, J, Heins, ZJ, Barron, DA, Shoushtari, AN, Scher, HI, Sadowska, J, Jonsson, P, Hakimi, AA, Omuro, AM, Son, JB, Sabbatini, PJ, Borsu, L, Dogan, S, Devlin, SM, Cambria, R, Hameed, M, Baselga, J, Liu, ZY, Schram, AM, Gounder, MM, Middha, S

Nat. Med. 2017
External Reference Information
External Reference
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Transcript
Other Identifiers
11732491_s_at
1654_at
17063631
206044_PM_s_at
206044_s_at
3076364
3076365
3076366
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3076441
3076442
3982166
3982173
40306_at
673
8143417
86199_r_at
A_23_P42935
GE58163
GE766137
GO:0000165
GO:0000166
GO:0001934
GO:0002318
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004709
GO:0005509
GO:0005515
GO:0005524
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005975
GO:0006468
GO:0007010
GO:0007155
GO:0007165
GO:0007173
GO:0008152
GO:0008542
GO:0009887
GO:0010628
GO:0010764
GO:0010828
GO:0012501
GO:0016020
GO:0016079
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030878
GO:0033077
GO:0033138
GO:0034446
GO:0035019
GO:0036211
GO:0042127
GO:0042802
GO:0043005
GO:0043066
GO:0043149
GO:0043226
GO:0043231
GO:0043367
GO:0043368
GO:0043369
GO:0043524
GO:0044297
GO:0045580
GO:0046632
GO:0046872
GO:0048538
GO:0048679
GO:0048680
GO:0048856
GO:0048870
GO:0050772
GO:0050852
GO:0050877
GO:0051496
GO:0055085
GO:0060291
GO:0060323
GO:0060324
GO:0070371
GO:0070374
GO:0070413
GO:0071277
GO:0071466
GO:0072577
GO:0090150
GO:0097110
GO:0098793
GO:0106310
GO:0140096
GO:1900026
GO:2000301
GO:2000352
HMNXSV003020754
ILMN_1652472
M95712_at
PH_hs_0027912
TC07001927.hg
g4757867_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
glycine 466 replaced with L-alanine
Coordinate
466
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-alanine.
A protein modification that effectively removes or replaces an glycine.
Name
O-phospho-L-serine at 445
Coordinate
445
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
COSMIC
IntEnz
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (26)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q02750 MAP2K1  20 0.978 62
 UniProt:P04049 RAF1  20 0.959 57
 UniProt:P63104 YWHAZ  2 0.91 11
 UniProt:P15056 BRAF  20 0.9 13
 UniProt:P31946 YWHAB  1 0.861 8
 UniProt:P61981 YWHAG  1 0.857 8
 UniProt:P27348 YWHAQ  1 0.857 8
 UniProt:P36507 MAP2K2  12 0.848 11
 UniProt:P01112 HRAS  20 0.831 6
 UniProt:P10398 ARAF  4 0.774 6
 UniProt:P01111 NRAS  20 0.751 5
 UniProt:Q04917 YWHAH  1 0.725 7
 UniProt:P62258 YWHAE  1 0.725 5
 UniProt:P08238 HSP90AB1  6 0.669 4
 UniProt:Q13233 MAP3K1  2 0.609 2
 UniProt:Q02156 PRKCE  2 0.589 3
 UniProt:P31947 SFN  1 0.564 3
 UniProt:P46940 IQGAP1  3 0.544 4
 UniProt:Q16543 CDC37  1 0.527 3
 UniProt:P38646 HSPA9  6 0.527 2
 UniProt:Q8N122 RPTOR  3 0.527 2
 UniProt:P11142 HSPA8  10 0.527 2
 UniProt:P11021 HSPA5  6 0.527 3
 UniProt:Q61097  5 0.499 3
 UniProt:Q99N57  10 0.499 3
 UniProt:P01116 KRAS  20 0.483 3
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