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About
What is Reactome ?
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Icon Info
Data Model
Computational inferred events
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p-S218,S222-MAP2K1
Stable Identifier
R-HSA-109837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S218,222-MEK1, Dual specificity mitogen-activated protein kinase kinase 1(phosphorylated), MAP kinase kinase 1(phosphorylated), p-S218,222-MAPKK 1, ERK activator kinase 1(phosphorylated), MAPK/ERK kinase 1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
MAP2K1 phosphorylates MAPK3 (Homo sapiens)
p-2S-MAP2K1:MAPK3 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Signaling by BRAF and RAF fusions (Homo sapiens)
BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAF is phosphorylated downstream of oncogenic RAS (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-Like Receptors Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
Dissociation of p-T,Y-MAPK3:MAP2K1 (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Inactivation of MAP2K1 by CDK1 (Homo sapiens)
MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
p-2S-MAP2K1:MAPK3 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
MAP2K1 phosphorylates MAPK3 (Homo sapiens)
p-2S-MAP2K1:MAPK3 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
Negative feedback regulation of MAPK pathway (Homo sapiens)
Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
RAF activating kinases [plasma membrane] (Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol] (Homo sapiens)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol] (Homo sapiens)
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02750 MAP2K1
Gene Names
MAP2K1, MEK1, PRKMK1
Chain
chain:1-393
Reference Genes
BioGPS Gene:5604 MAP2K1
COSMIC (genes):MAP2K1 MAP2K1
CTD Gene:5604 MAP2K1
dbSNP Gene:5604 MAP2K1
ENSEMBL:ENSG00000169032 MAP2K1
HGNC:6840 MAP2K1
KEGG Gene (Homo sapiens):hsa:5604 MAP2K1
Monarch:5604 MAP2K1
NCBI Gene:5604 MAP2K1
OMIM:176872 MAP2K1
UCSC:Q02750 MAP2K1
Reference Transcript
RefSeq:NM_002755.3 MAP2K1
RefSeq:XM_017022411.1 MAP2K1
Other Identifiers
0001740347
1130_at
11717291_a_at
11749555_a_at
11757478_s_at
16802190
1844_s_at
1S9J
202670_at
26430
2P55
3834
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3W8Q
3WIG
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
4LMN
4MNE
4U7Z
4U80
4U81
5604
5BX0
5EYM
5HZE
7984319
A4QPA9
A_23_P20248
AAA36318
AAI37460
AAI39730
AK291500
BAF84189
BC137459
BC139729
CAB003834
CCDS10216
CH471082
EAW77765
ENSG00000169032
ENSP00000302486
ENST00000307102
EntrezGene:5604
GE57608
GO:0000003
GO:0000165
GO:0000166
GO:0000187
GO:0000278
GO:0000902
GO:0001932
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0004728
GO:0004871
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006412
GO:0006464
GO:0006468
GO:0006810
GO:0006928
GO:0006935
GO:0006950
GO:0007049
GO:0007050
GO:0007165
GO:0007346
GO:0007507
GO:0007568
GO:0008022
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0009790
GO:0010628
GO:0010629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0016791
GO:0018108
GO:0021697
GO:0030154
GO:0030182
GO:0030216
GO:0030234
GO:0030878
GO:0031410
GO:0032872
GO:0034641
GO:0035897
GO:0040011
GO:0042981
GO:0043167
GO:0043226
GO:0043539
GO:0045597
GO:0045893
GO:0047485
GO:0048538
GO:0048646
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060020
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0060674
GO:0060711
GO:0070062
GO:0070371
GO:0070374
GO:0071902
GO:0090170
GO:0090398
GO:1903800
GO:2000641
HGNC:6840
HPA026430
Hs.3446.0.A2_3p_at
ILMN_1694240
IPR000719
IPR008271
IPR011009
IPR017441
L05624
L05624_s_at
L11284
L11284_at
LRG_725
LRG_725t1
MAP2K1
MAP2K1-201
MIM:163950
MIM:176872
MIM:615279
NM_002755
NP_002746
PF00069
PH_hs_0022483
SM00220
TC15000613.hg
uc010bhq.4
UPI000013EBC9
XM_011521783
XM_017022411
XM_017022412
XP_011520085
XP_016877900
XP_016877901
Participant Of
input
MAP2K1 binds MAPK3
hasMember
MAP2K1 [cytosol]
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol]
hasComponent
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
p-2S-MAP2K1:MAPK3 [cytosol]
p-S218,S222 MAP2K1 dimer [cytosol]
p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol]
output
Dissociation of p-T,Y-MAPK3:MAP2K1
Other forms of this molecule
MAP2K1(9-393) [cytosol]
MAP2K1(2-8) [cytosol]
p-S,218, S222,T292 MAP2K1 [cytosol]
p-T286,T292-MAP2K1 [cytosol]
p-S218,S222,T286,T292-MAP2K1 [cytosol]
MAP2K1 [cytosol]
Inferred To
Homologues of p-S218,S222-MAP2K1 [cytosol] (Arabidopsis thaliana)
Homologues of p-S218,S222-MAP2K1 [cytosol] (Canis familiaris)
Homologues of p-S218,S222-MAP2K1 [cytosol] (Oryza sativa)
Homologues of p-S218,S222-MAP2K1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-S218,S222-MAP2K1 [cytosol] (Arabidopsis thaliana)
phospho-p-S218,S222-MAP2K1 [cytosol] (Bos taurus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Caenorhabditis elegans)
phospho-p-S218,S222-MAP2K1 [cytosol] (Canis familiaris)
phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)
phospho-p-S218,S222-MAP2K1 [cytosol] (Dictyostelium discoideum)
phospho-p-S218,S222-MAP2K1 [cytosol] (Drosophila melanogaster)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Mus musculus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Oryza sativa)
phospho-p-S218,S222-MAP2K1 [cytosol] (Rattus norvegicus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Saccharomyces cerevisiae)
phospho-p-S218,S222-MAP2K1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-S218,S222-MAP2K1 [cytosol] (Sus scrofa)
phospho-p-S218,S222-MAP2K1 [cytosol] (Taeniopygia guttata)
phospho-p-S218,S222-MAP2K1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 218
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_016877900.1
,
NP_002746.1
ZINC - World Drugs
MP2K1_HUMAN
Brenda
2.7.12.2
ZINC - FDA approved
MP2K1_HUMAN
ZINC - Substances
MP2K1_HUMAN
ZINC - Biogenic
MP2K1_HUMAN
ZINC target
Q02750
PRO
Q02750
PDB
4U7Z
,
3SLS
,
3V01
,
3DV3
,
4U80
,
3V04
,
4U81
,
3DY7
,
3VVH
,
3W8Q
,
3E8N
,
4ANB
,
3MBL
,
4ARK
,
3ORN
,
4LMN
,
3OS3
,
1S9J
,
3PP1
,
2P55
,
4MNE
,
3ZM4
,
3EQF
,
4AN2
,
3EQG
,
3EQD
,
3ZLY
,
3ZLX
,
3EQC
,
3ZLW
,
5HZE
,
5EYM
,
3ZLS
,
3EQB
,
3WIG
,
5BX0
,
3EQI
,
4AN9
,
3EQH
,
4AN3
ZINC - Metabolites
MP2K1_HUMAN
GeneCards
Q02750
DOCK Blaster
1S9J
,
4AN9
,
3DV3
,
4AN2
,
3SLS
,
4AN3
,
3VVH
,
3DY7
,
3PP1
,
4ANB
,
3W8Q
,
3ORN
,
5HZE
,
2P55
,
4U7Z
,
4ARK
,
4LMN
,
3EQG
,
5EYM
,
3EQH
,
3EQI
,
3EQB
,
3EQC
,
3EQD
,
4U81
,
4U80
,
3ZM4
,
3V04
,
3ZLS
,
3V01
,
3MBL
,
3ZLY
,
3ZLX
,
3ZLW
,
3OS3
,
5BX0
,
4MNE
,
3WIG
,
3E8N
,
3EQF
ZINC - Predictions - Purchasable
MP2K1_HUMAN
Orphanet
16377
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15056 BRAF
35
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
D594N BRAF [cytosol]
(R-HSA-6802299)
G596R BRAF [cytosol]
(R-HSA-6802385)
D594V BRAF [cytosol]
(R-HSA-6802305)
G466E BRAF [cytosol]
(R-HSA-6802374)
D594G BRAF [cytosol]
(R-HSA-6802295)
F595L BRAF [cytosol]
(R-HSA-6802316)
L597V BRAF [cytosol]
(R-HSA-6802397)
G464E BRAF [cytosol]
(R-HSA-6802369)
E586K BRAF [cytosol]
(R-HSA-6802308)
V600K BRAF [cytosol]
(R-HSA-6802502)
p-L597V BRAF [plasma membrane]
(R-HSA-8936647)
p-G464E BRAF [plasma membrane]
(R-HSA-8936645)
p-F595L BRAF [plasma membrane]
(R-HSA-8936641)
p-E586K BRAF [plasma membrane]
(R-HSA-8936639)
p-V600K BRAF [plasma membrane]
(R-HSA-8936651)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
G469A BRAF [cytosol]
(R-HSA-6802381)
V600E BRAF [cytosol]
(R-HSA-6802498)
V600E BRAF V169_M438del [cytosol]
(R-HSA-6802489)
V600E BRAF V47_D380del [cytosol]
(R-HSA-6802491)
V600E BRAF V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
BRAF [endosome]
(R-HSA-190063)
p-S338-BRAF [plasma membrane]
(R-HSA-1063700)
BRAF [plasma membrane]
(R-HSA-934547)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
BRAF [cytosol]
(R-HSA-167224)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.976
58
UniProt:P04049 RAF1
11
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [plasma membrane]
(R-HSA-444236)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.952
35
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.69
5
UniProt:Q8IVT5 KSR1
5
p-S311,S406 KSR1 [cytosol]
(R-HSA-5672654)
KSR1 [cytosol]
(R-HSA-5672587)
p-S311 KSR1 [cytosol]
(R-HSA-5672652)
p-S311,Y552 KSR1 [plasma membrane]
(R-HSA-5672659)
p-S311,Y552 KSR1 [cytosol]
(R-HSA-5672656)
0.643
7
UniProt:P28482 MAPK1
7
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
0.609
2
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.556
3
UniProt:P46937 YAP1
7
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
YAP1 [nucleoplasm]
(R-HSA-1253322)
YAP1 [cytosol]
(R-HSA-1253345)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
0.556
3
UniProt:P31946 YWHAB
2
YWHAB [endosome]
(R-HSA-190058)
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
UniProt:Q86Y07 VRK2
0.524
2
UniProt:Q61097
5
phospho-p-S311,S406 KSR1 [cytosol]
(R-MMU-5672654)
KSR1 [cytosol]
(R-MMU-5672587)
phospho-p-S311 KSR1 [cytosol]
(R-MMU-5672652)
phospho-p-S311,Y552 KSR1 [plasma membrane]
(R-MMU-5672659)
phospho-p-S311,Y552 KSR1 [cytosol]
(R-MMU-5672656)
0.508
2
UniProt:Q13526 PIN1
1
PIN1 [nucleoplasm]
(R-HSA-936016)
0.508
5
UniProt:P27361 MAPK3
4
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
0.499
2
UniProt:Q86Y07-1 VRK2
0.499
2
UniProt:Q8N9N5-2 BANP
0.488
2
UniProt:Q9H8W4 PKHF2
0.488
4
UniProt:Q49A26-4 GLYR1
0.488
2
UniProt:Q96S96 PEBP4
0.462
3
UniProt:O75832 PSMD10
2
PSMD10 [cytosol]
(R-HSA-68788)
PSMD10 [nucleoplasm]
(R-HSA-174322)
0.462
2
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