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SIRT4 [mitochondrial matrix]
Stable Identifier
R-HSA-5687775
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
fullName evidence="1"NAD-dependent protein deacetylase sirtuin-4 ecNumber evidence="1"3.5.1.-/ecNumber, SIR4_HUMAN
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
SIRT4 transfers ADPRib to GLUD (Homo sapiens)
SIRT4 [mitochondrial matrix] (Homo sapiens)
SIRT4:Zn2+ [mitochondrial matrix] (Homo sapiens)
SIRT4 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6E7 SIRT4
Gene Names
SIRT4, SIR2L4
Chain
transit peptide:1-28, chain:29-314
Reference Genes
BioGPS Gene:23409 SIRT4
COSMIC (genes):SIRT4 SIRT4
CTD Gene:23409 SIRT4
dbSNP Gene:23409 SIRT4
ENSEMBL:ENSG00000089163 SIRT4
HGNC:14932 SIRT4
KEGG Gene (Homo sapiens):23409 SIRT4
Monarch:23409 SIRT4
NCBI Gene:23409 SIRT4
OMIM:604482 SIRT4
UCSC:Q9Y6E7 SIRT4
Reference Transcript
RefSeq:NM_012240.2 SIRT4
RefSeq:XM_006719308.2 SIRT4
RefSeq:XM_006719309.3 SIRT4
Other Identifiers
0003390315
11728178_at
16757873
220047_at
222248_s_at
23409
3434312
3434316
3434319
3434320
3434321
3434322
3434323
45696_at
7959148
A_23_P99226
GE58474
GO:0000820
GO:0003674
GO:0003950
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0006464
GO:0006471
GO:0006476
GO:0006520
GO:0006541
GO:0006605
GO:0006629
GO:0006810
GO:0006950
GO:0006974
GO:0007005
GO:0007267
GO:0008150
GO:0008219
GO:0008270
GO:0009058
GO:0010667
GO:0015031
GO:0016740
GO:0016757
GO:0016810
GO:0034641
GO:0034983
GO:0043167
GO:0043226
GO:0044281
GO:0046322
GO:0046676
GO:0046872
GO:0046889
GO:0047708
GO:0051604
GO:0061690
GO:0070403
GO:0071456
GO:0072350
GO:1903217
GO:1904182
HMNXSV003048767
Hs.50861.1.S1_3p_a_at
ILMN_1657868
TC12000942.hg
Participates
as a component of
SIRT4:Zn2+ [mitochondrial matrix] (Homo sapiens)
Inferred To
sir-2.2 [mitochondrial matrix]
(Caenorhabditis elegans)
SIRT4 [mitochondrial matrix]
(Canis familiaris)
SIRT4 [mitochondrial matrix]
(Gallus gallus)
Sirt4 [mitochondrial matrix]
(Drosophila melanogaster)
Sirt4 [mitochondrial matrix]
(Mus musculus)
Sirt4 [mitochondrial matrix]
(Rattus norvegicus)
sirt4 [mitochondrial matrix]
(Danio rerio)
sirt4 [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
XP_006719372.1
,
NP_036372.1
,
XP_006719371.1
Guide to Pharmacology - Targets
2710
OpenTargets
ENSG00000089163
IntEnz
2.3.1.286
GeneCards
Q9Y6E7
HPA
ENSG00000089163-SIRT4
Ensembl
ENSG00000089163
,
ENSP00000202967
,
ENST00000202967
PRO
Q9Y6E7
Pharos - Targets
Q9Y6E7
HMDB Protein
HMDBP08882
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10809 HSPD1
6
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
0.527
2
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