Reactome | PPM1D [nucleoplasm]

PPM1D [nucleoplasm]

Stable Identifier

R-HSA-2562518

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WIP1, Protein phosphatase 1D

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15297 PPM1D

Gene Names

PPM1D, WIP1

Chain

chain:1-605

Reference Genes

BioGPS Gene:8493 PPM1D

COSMIC (genes):PPM1D PPM1D

CTD Gene:8493 PPM1D

dbSNP Gene:8493 PPM1D

ENSEMBL:ENSG00000170836 PPM1D

ENSEMBL_homo_sapiens_GENE:ENSG00000170836.13 PPM1D

HGNC:9277 PPM1D

KEGG Gene (Homo sapiens):8493 PPM1D

Monarch:8493 PPM1D

NCBI Gene:8493 PPM1D

OMIM:605100 PPM1D

UCSC:O15297 PPM1D

Reference Transcript

RefSeq:NM_003620.3 PPM1D

Other Identifiers

11739369_s_at

11739370_a_at

11751018_a_at

11752090_a_at

16836684

204566_PM_at

204566_at

230330_PM_at

230330_at

37107_at

3729538

3729539

3729540

3729541

3729542

3729543

3729546

3729549

3729550

3729551

3729552

3729553

3729554

3729556

3729557

3729558

3729559

3729560

51609_r_at

8008922

8493

A_14_P126509

A_32_P150030

A_33_P3302696

GE79845

GO:0000086

GO:0000278

GO:0003824

GO:0004674

GO:0004721

GO:0004722

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006306

GO:0006325

GO:0006351

GO:0006355

GO:0006470

GO:0007049

GO:0008285

GO:0009267

GO:0009314

GO:0009617

GO:0016740

GO:0016787

GO:0017018

GO:0023052

GO:0030330

GO:0031507

GO:0035970

GO:0036211

GO:0043169

GO:0043226

GO:0045814

GO:0046872

GO:0051019

GO:0060260

GO:0140096

HMNXSV003007394

Hs.286073.0.A1_3p_at

ILMN_1670875

PH_hs_0023484

TC17000739.hg

TC17002305.hg

g4505996_3p_at

Inferred To

Pp2C1 [nucleoplasm] (Drosophila melanogaster)

ppm-1.d [nucleoplasm] (Caenorhabditis elegans)

PPM1D [nucleoplasm] (Bos taurus)

PPM1D [nucleoplasm] (Canis familiaris)

PPM1D [nucleoplasm] (Gallus gallus)

PPM1D [nucleoplasm] (Mus musculus)

PPM1D [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003611.1

Guide to Pharmacology - Targets

3134

OpenTargets

ENSG00000170836

GeneCards

O15297

HPA

ENSG00000170836-PPM1D

ZINC - Substances

PPM1D_HUMAN

ZINC target

O15297

Ensembl

ENSG00000170836, ENST00000305921, ENSP00000376720, ENST00000392995, ENSP00000306682

PRO

O15297

Pharos - Targets

O15297

Orphanet

23354

HMDB Protein

HMDBP08794

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13950 RUNX2			0.602	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.544	4
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.544	3
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.527	2
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.527	2

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