Reactome | p-S189 MAPK6 [nucleoplasm]

p-S189 MAPK6 [nucleoplasm]

Stable Identifier

R-HSA-5687015

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ERK3, PRKM6

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External Reference Information

External Reference

UniProt:Q16659 MAPK6 gene

Gene Names

MAPK6 gene, MAPK6, ERK3, PRKM6

Chain

chain:1-721

Reference Genes

BioGPS Gene:5597 MAPK6 gene

COSMIC (genes):MAPK6 MAPK6 gene

CTD Gene:5597 MAPK6 gene

dbSNP Gene:5597 MAPK6 gene

ENSEMBL:ENSG00000069956 MAPK6 gene

HGNC:6879 MAPK6 gene

Monarch:5597 MAPK6 gene

NCBI Gene:5597 MAPK6 gene

OMIM:602904 MAPK6 gene

UCSC:Q16659 MAPK6 gene

Reference Transcript

Other Identifiers

11722796_a_at

16801179

207121_PM_s_at

207121_s_at

243831_PM_at

243831_at

3098308

3111632

3111634

3133821

3246221

3246228

3511512

3511517

3594130

3594140

3594142

3594143

3594144

3594145

3594146

3594147

3594150

3594153

3594154

3594155

3594156

3594157

3594158

3594160

36926_at

3926771

5597

76525_at

7983763

A_14_P137682

A_23_P3204

A_24_P333663

GE728188

GE79439

GO:0000165

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006468

GO:0007165

GO:0016740

GO:0019901

GO:0032156

GO:0032991

GO:0035556

GO:0043226

GO:0046982

GO:0060999

GO:0106310

GO:0140096

HMNXSV003053235

Hs.122812.0.A1_3p_at

ILMN_1757287

PH_hs_0029556

TC15000417.hg

X80692_at

g4506090_3p_a_at

Participates

as a member of

p-S MAPK6,4 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-3S,T MAPK6 [nucleoplasm]

MAPK6 [nucleoplasm]

p-S189 MAPK6 [cytosol]

MAPK6 [cytosol]

ub-MAPK6 [cytosol]

Inferred To

Homologues of p-S189 MAPK6 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of p-S189 MAPK6 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-S189 MAPK6 [nucleoplasm] (Bos taurus)

phospho-p-S189 MAPK6 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S189 MAPK6 [nucleoplasm] (Canis familiaris)

phospho-p-S189 MAPK6 [nucleoplasm] (Danio rerio)

phospho-p-S189 MAPK6 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-S189 MAPK6 [nucleoplasm] (Gallus gallus)

phospho-p-S189 MAPK6 [nucleoplasm] (Mus musculus)

phospho-p-S189 MAPK6 [nucleoplasm] (Plasmodium falciparum)

phospho-p-S189 MAPK6 [nucleoplasm] (Rattus norvegicus)

phospho-p-S189 MAPK6 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-S189 MAPK6 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-S189 MAPK6 [nucleoplasm] (Sus scrofa)

phospho-p-S189 MAPK6 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 189

Coordinate

189

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

ZINC - World Drugs

MK06_HUMAN

Guide to Pharmacology - Targets

2092

OpenTargets

ENSG00000069956

ENSEMBL

ENSP00000505862, ENST00000681888, ENST00000680066, ENSP00000505601, ENST00000691380, ENSP00000509662, ENST00000261845, ENSP00000506036, ENSP00000506184, ENST00000680777, ENSP00000261845, ENST00000680652

ZINC - FDA approved

MK06_HUMAN

ZINC - Substances

MK06_HUMAN

ZINC - Biogenic

MK06_HUMAN

ZINC target

Q16659

PRO

Q16659

PDB

7AQB, 6YLC, 6YKY, 6YLL

ZINC - Investigational

MK06_HUMAN

HPA

ENSG00000069956-MAPK6

Pharos - Targets

Q16659

ZINC - Predictions - Purchasable

MK06_HUMAN

HMDB Protein

HMDBP01527

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IW41 MAPKAPK5	5	p-T182 MAPKAPK5 [cytosol] (R-HSA-5687004) p-S115 MAPKAPK5 [cytosol] (R-HSA-5687028) p-S115 MAPKAPK5 [nucleoplasm] (R-HSA-5687026) p-T182-MAPKAPK5 [nucleoplasm] (R-HSA-3239018) MAPKAPK5 [nucleoplasm] (R-HSA-2562517)	0.917	12
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.837	8
UniProt:Q8IW41-2 MAPKAPK5			0.742	6
UniProt:Q96JN8 NEUL4			0.725	5
UniProt:Q9H6Z9 EGLN3	2	EGLN3 [nucleoplasm] (R-HSA-1234104) EGLN3 [cytosol] (R-HSA-1234115)	0.681	6
UniProt:P02647 APOA1	11	APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.659	3
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.643	3
UniProt:Q9Y4C2 TCAF1			0.643	4
UniProt:Q9GZV1 ANKR2			0.556	7
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.547	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.547	2
UniProt:Q99613 EIF3C	1	EIF3C [cytosol] (R-HSA-72550)	0.547	2
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.527	2
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:P02768 ALB	7	ALB(19-609) [extracellular region] (R-HSA-114609) ALB [platelet alpha granule lumen] (R-HSA-49865) salicyl-ALB [extracellular region] (R-HSA-9750694) acetyl-ALB [extracellular region] (R-HSA-9749660) ALB [extracellular region] (R-HSA-194115) p-ALB [endoplasmic reticulum lumen] (R-HSA-8956930) ALB [endoplasmic reticulum lumen] (R-HSA-8956690)	0.527	2
UniProt:P17097 ZNF7			0.527	2
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.527	2
UniProt:P17035 ZNF28	1	ZNF28 [nucleoplasm] (R-HSA-1027421)	0.527	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	2
UniProt:P02763 ORM1	4	ORM1 [platelet alpha granule lumen] (R-HSA-8848906) ORM1 [tertiary granule lumen] (R-HSA-6801026) ORM1 [extracellular region] (R-HSA-6799687) ORM1 [specific granule lumen] (R-HSA-6799632)	0.527	2
UniProt:Q6ZN06 ZN813			0.527	2
UniProt:P02765 AHSG	5	AHSG [platelet alpha granule lumen] (R-HSA-8848910) AHSG [extracellular region] (R-HSA-6804820) AHSG [secretory granule lumen] (R-HSA-6804806) p-AHSG [endoplasmic reticulum lumen] (R-HSA-8957019) AHSG [endoplasmic reticulum lumen] (R-HSA-8956762)	0.527	2
UniProt:P02787 TF	6	TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [endosome membrane] (R-HSA-917974) apoTF [extracellular region] (R-HSA-350754) TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140)	0.527	2
UniProt:Q5SW79 CE170			0.527	2
UniProt:P68871 HBB	8	HBB [lysosomal lumen] (R-HSA-9625193) HBB [cytosol] (R-HSA-1008196) HBB [late endosome lumen] (R-HSA-9631108) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [extracellular region] (R-HSA-2168872) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [endocytic vesicle lumen] (R-HSA-2230936) CO-H+-HBB [cytosol] (R-HSA-1237013)	0.527	2
UniProt:O75521 ECI2			0.527	2
UniProt:Q96JN8-2 NEURL4			0.527	5
UniProt:P69905 HBA1	4	HBA1 [extracellular region] (R-HSA-2168862) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [cytosol] (R-HSA-1008268) CO-H+-HBA1 [cytosol] (R-HSA-1237026)	0.527	2
UniProt:Q8IZT6 ASPM			0.527	2
UniProt:P00738 HP	7	HP [specific granule lumen] (R-HSA-6799622) HP [extracellular region] (R-HSA-6799677) HP [tertiary granule lumen] (R-HSA-6800879) 7xHC-HP(19-160) [extracellular region] (R-HSA-2168848) 5xHC-HP(162-406) [extracellular region] (R-HSA-2168875) 7xHC-HP(19-160) [endocytic vesicle lumen] (R-HSA-2230994) 5xHC-HP(162-406) [endocytic vesicle lumen] (R-HSA-2230973)	0.527	2
UniProt:Q14147 DHX34			0.527	2
UniProt:P01024 C3	20	C3d fragment [extracellular region] (R-HSA-198999) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3a-desArg [extracellular region] (R-HSA-8852808) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821)	0.527	2
UniProt:Q6P1M0 SLC27A4	6	SLC27A4 A92T [plasma membrane] (R-HSA-5627896) SLC27A4 R583H [plasma membrane] (R-HSA-5627897) SLC27A4 Q300R [plasma membrane] (R-HSA-5627918) SLC27A4 S247P [plasma membrane] (R-HSA-5627907) SLC27A4 C168* [plasma membrane] (R-HSA-5627910) SLC27A4 [plasma membrane] (R-HSA-879638)	0.527	2
UniProt:P12504 VIF			0.499	2

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