Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CHI3L1 [extracellular region]
Stable Identifier
R-HSA-6806319
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Chitinase-3-like protein 1, CH3L1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
CHI3L1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36222 CHI3L1
Gene Names
CHI3L1
Chain
signal peptide:1-21, chain:22-383
Reference Genes
BioGPS Gene:1116 CHI3L1
COSMIC (genes):CHI3L1 CHI3L1
CTD Gene:1116 CHI3L1
dbSNP Gene:1116 CHI3L1
ENSEMBL:ENSG00000133048 CHI3L1
HGNC:1932 CHI3L1
KEGG:hsa:1116 CHI3L1
Monarch:1116 CHI3L1
NCBI Gene:1116 CHI3L1
OMIM:601525 CHI3L1
UCSC:P36222 CHI3L1
Reference Transcript
RefSeq:NM_001276.4 CHI3L1
Participates
as a member of
Specific granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
CHI3L1 [specific granule lumen]
Inferred To
Cht7 [extracellular region]
(Drosophila melanogaster)
Homologues of CHI3L1 [extracellular region]
(Caenorhabditis elegans)
Homologues of CHI3L1 [extracellular region]
(Danio rerio)
Homologues of CHI3L1 [extracellular region]
(Drosophila melanogaster)
chia.1 [extracellular region]
(Danio rerio)
cht-3 [extracellular region]
(Caenorhabditis elegans)
cht-4 [extracellular region]
(Caenorhabditis elegans)
Idgf4 [extracellular region]
(Drosophila melanogaster)
Idgf5 [extracellular region]
(Drosophila melanogaster)
Idgf6 [extracellular region]
(Drosophila melanogaster)
Idgf3 [extracellular region]
(Drosophila melanogaster)
CHT1 [extracellular region]
(Plasmodium falciparum)
Chi3l1 [extracellular region]
(Mus musculus)
Chi3l1 [extracellular region]
(Rattus norvegicus)
chia.3 [extracellular region]
(Danio rerio)
chia.4 [extracellular region]
(Danio rerio)
chia.2 [extracellular region]
(Danio rerio)
CHI3L1 [extracellular region]
(Bos taurus)
CHI3L1 [extracellular region]
(Canis familiaris)
CHI3L1 [extracellular region]
(Sus scrofa)
chia.6 [extracellular region]
(Danio rerio)
Cht10 [extracellular region]
(Drosophila melanogaster)
Cht11 [extracellular region]
(Drosophila melanogaster)
Idgf1 [extracellular region]
(Drosophila melanogaster)
Idgf2 [extracellular region]
(Drosophila melanogaster)
cht-1 [extracellular region]
(Caenorhabditis elegans)
CTS2 [extracellular region]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001267.2
Guide to Pharmacology - Targets
2987
ENSEMBL
ENST00000255409
,
ENSP00000255409
,
ENSG00000133048
OpenTargets
ENSG00000133048
GeneCards
CHI3L1
HPA
ENSG00000133048-CHI3L1
PRO
P36222
Pharos - Targets
P36222
GlyGen
P36222
HMDB Protein
HMDBP11635
PDB
8R4X
,
1NWT
,
1NWU
,
8R42
,
1HJX
,
1HJV
,
1HJW
,
1NWR
,
8DF1
,
7CJ2
,
1NWS
,
8R41
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.804
9
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
0.527
2
UniProt:Q9NXR7 BRE
2
BRE [nucleoplasm]
(R-HSA-5682579)
BRE [cytosol]
(R-HSA-5691413)
0.527
2
UniProt:P17931 LGALS3
3
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
0.524
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.471
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.471
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text