Reactome | CHI3L1 [extracellular region]

CHI3L1 [extracellular region]

Stable Identifier

R-HSA-6806319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Chitinase-3-like protein 1, CH3L1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P36222 CHI3L1

Gene Names

CHI3L1

Chain

signal peptide:1-21, chain:22-383

Reference Genes

BioGPS Gene:1116 CHI3L1

COSMIC (genes):CHI3L1 CHI3L1

CTD Gene:1116 CHI3L1

dbSNP Gene:1116 CHI3L1

ENSEMBL:ENSG00000133048 CHI3L1

HGNC:1932 CHI3L1

KEGG:hsa:1116 CHI3L1

Monarch:1116 CHI3L1

NCBI Gene:1116 CHI3L1

OMIM:601525 CHI3L1

UCSC:P36222 CHI3L1

Reference Transcript

RefSeq:NM_001276.4 CHI3L1

Participates

as a member of

Specific granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

CHI3L1 [specific granule lumen]

Inferred To

Cht7 [extracellular region] (Drosophila melanogaster)

Homologues of CHI3L1 [extracellular region] (Caenorhabditis elegans)

Homologues of CHI3L1 [extracellular region] (Danio rerio)

Homologues of CHI3L1 [extracellular region] (Drosophila melanogaster)

chia.1 [extracellular region] (Danio rerio)

cht-3 [extracellular region] (Caenorhabditis elegans)

cht-4 [extracellular region] (Caenorhabditis elegans)

Idgf4 [extracellular region] (Drosophila melanogaster)

Idgf5 [extracellular region] (Drosophila melanogaster)

Idgf6 [extracellular region] (Drosophila melanogaster)

Idgf3 [extracellular region] (Drosophila melanogaster)

CHT1 [extracellular region] (Plasmodium falciparum)

Chi3l1 [extracellular region] (Mus musculus)

Chi3l1 [extracellular region] (Rattus norvegicus)

chia.3 [extracellular region] (Danio rerio)

chia.4 [extracellular region] (Danio rerio)

chia.2 [extracellular region] (Danio rerio)

CHI3L1 [extracellular region] (Bos taurus)

CHI3L1 [extracellular region] (Canis familiaris)

CHI3L1 [extracellular region] (Sus scrofa)

chia.6 [extracellular region] (Danio rerio)

Cht10 [extracellular region] (Drosophila melanogaster)

Cht11 [extracellular region] (Drosophila melanogaster)

Idgf1 [extracellular region] (Drosophila melanogaster)

Idgf2 [extracellular region] (Drosophila melanogaster)

cht-1 [extracellular region] (Caenorhabditis elegans)

CTS2 [extracellular region] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001267.2

Guide to Pharmacology - Targets

2987

ENSEMBL

ENST00000255409, ENSP00000255409, ENSG00000133048

OpenTargets

ENSG00000133048

GeneCards

CHI3L1

HPA

ENSG00000133048-CHI3L1

PRO

P36222

Pharos - Targets

P36222

GlyGen

P36222

HMDB Protein

HMDBP11635

PDB

8R4X, 1NWT, 1NWU, 8R42, 1HJX, 1HJV, 1HJW, 1NWR, 8DF1, 7CJ2, 1NWS, 8R41

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.804	9
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [endoplasmic reticulum lumen] (R-HSA-195905)	0.527	2
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.527	2
UniProt:P17931 LGALS3	3	LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307)	0.524	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.471	2