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Dhp-K50-EIF5A2 [cytosol]
Stable Identifier
R-HSA-3149584
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
EIF5A2(Dhp), Eukaryotic tranlation initiation factor 5A2
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Hypusine synthesis from eIF5A-lysine (Homo sapiens)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)
Dhp-K50-EIF5A [cytosol] (Homo sapiens)
Dhp-K50-EIF5A2 [cytosol] (Homo sapiens)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)
Dhp-K50-EIF5A [cytosol] (Homo sapiens)
Dhp-K50-EIF5A2 [cytosol] (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
Dhp-K50-EIF5A [cytosol] (Homo sapiens)
Dhp-K50-EIF5A2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZV4 EIF5A2
Gene Names
EIF5A2
Chain
initiator methionine:, chain:2-153
Reference Genes
BioGPS Gene:56648 EIF5A2
COSMIC (genes):EIF5A2 EIF5A2
CTD Gene:56648 EIF5A2
dbSNP Gene:56648 EIF5A2
ENSEMBL:ENSG00000163577 EIF5A2
ENSEMBL_homo_sapiens_GENE:ENSG00000163577.8 EIF5A2
HGNC:3301 EIF5A2
KEGG Gene (Homo sapiens):56648 EIF5A2
Monarch:56648 EIF5A2
NCBI Gene:56648 EIF5A2
OMIM:605782 EIF5A2
UCSC:Q9GZV4 EIF5A2
Reference Transcript
RefSeq:NM_020390.5 EIF5A2
Other Identifiers
11729833_at
11729834_at
11729835_at
11729836_at
16961475
220198_PM_s_at
220198_s_at
235289_PM_at
235289_at
235296_PM_at
235296_at
2554017
2705161
2705163
2705165
2705166
2705167
2705168
2705172
2705173
2705174
2705176
3631894
53758_at
56648
60580_r_at
61488_at
8092073
84115_at
A_24_P380022
A_24_P385739
GE62579
GO:0003723
GO:0003746
GO:0005515
GO:0005634
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006412
GO:0006414
GO:0007283
GO:0016020
GO:0022414
GO:0043022
GO:0043226
GO:0043231
GO:0045182
GO:0045901
GO:0045905
HMNXSV003007187
Hs.164144.0.A1_3p_at
Hs.71528.0.A1_3p_at
ILMN_1735151
ILMN_2071737
PH_hs_0009926
TC03001995.hg
g11181773_3p_a_at
Participates
as a member of
Dhp-K50-EIF5A [cytosol] (Homo sapiens)
Other forms of this molecule
Hyp-K50-EIF5A2 [cytosol]
EIF5A2 [cytosol]
Inferred To
eEF5 [cytosol]
(Drosophila melanogaster)
tif51b [cytosol]
(Schizosaccharomyces pombe)
EIF5A2 [cytosol]
(Bos taurus)
EIF5A2 [cytosol]
(Canis familiaris)
EIF5A2 [cytosol]
(Gallus gallus)
HYP2 [cytosol]
(Saccharomyces cerevisiae)
iff-2 [cytosol]
(Caenorhabditis elegans)
tif51a [cytosol]
(Schizosaccharomyces pombe)
Eif5a2 [cytosol]
(Mus musculus)
Eif5a2 [cytosol]
(Rattus norvegicus)
eif5a2 [cytosol]
(Danio rerio)
ANB1 [cytosol]
(Saccharomyces cerevisiae)
Dhp-K50-EIF5A2 [cytosol]
(Plasmodium falciparum)
Dhp-K50-EIF5A2 [cytosol]
(Sus scrofa)
Homologues of Dhp-K50-EIF5A2 [cytosol]
(Caenorhabditis elegans)
Homologues of Dhp-K50-EIF5A2 [cytosol]
(Danio rerio)
Homologues of Dhp-K50-EIF5A2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of Dhp-K50-EIF5A2 [cytosol]
(Schizosaccharomyces pombe)
iff-1 [cytosol]
(Caenorhabditis elegans)
eif5a [cytosol]
(Danio rerio)
eif5a [cytosol]
(Dictyostelium discoideum)
eif5a [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
L-deoxyhypusine at 50
Coordinate
50
PsiMod Name
L-deoxyhypusine
PsiMod Definition
modification from RESID
Cross References
RefSeq
NP_065123.1
OpenTargets
ENSG00000163577
HPA
ENSG00000163577-EIF5A2
GeneCards
Q9GZV4
Ensembl
ENSP00000295822
,
ENSG00000163577
,
ENST00000295822
PRO
Q9GZV4
Pharos - Targets
Q9GZV4
HMDB Protein
HMDBP10821
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.718
6
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