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RALGDS [cytosol]
Stable Identifier
R-HSA-171001
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RalGDS, Guanine-nucleotide releasing factor
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS:GTP binds RAL GDS proteins (Homo sapiens)
RAL GDS proteins [cytosol] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins [plasma membrane] (Homo sapiens)
RAL GDS proteins [cytosol] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
Guanine nucleotide exchange on RAL (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Ral-GDS binds to Ras-GTP (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12967 RALGDS
Gene Names
RALGDS, KIAA1308, RGF
Chain
chain:1-914
Reference Genes
BioGPS Gene:5900 RALGDS
COSMIC (genes):RALGDS RALGDS
CTD Gene:5900 RALGDS
dbSNP Gene:5900 RALGDS
ENSEMBL:ENSG00000160271 RALGDS
HGNC:9842 RALGDS
KEGG Gene (Homo sapiens):5900 RALGDS
Monarch:5900 RALGDS
NCBI Gene:5900 RALGDS
OMIM:601619 RALGDS
UCSC:Q12967 RALGDS
Reference Transcript
RefSeq:NM_001271776.1 RALGDS
RefSeq:NM_006266.3 RALGDS
RefSeq:NM_001271774.1 RALGDS
RefSeq:NM_001271775.1 RALGDS
RefSeq:NM_001042368.2 RALGDS
Other Identifiers
0005690711
11737952_a_at
11741359_a_at
11741360_x_at
11752122_a_at
11757908_x_at
17099403
209050_s_at
209051_s_at
3228464
3228465
3228471
3228475
3228477
3228479
3228480
3228481
3228484
3228485
3228487
3228488
3228489
3228490
3228491
3228492
3228493
3228495
3228497
3228498
3228500
3228501
3228509
3228510
3228516
3228517
3228518
3228522
34254_at
5900
8164810
91384_at
GE503857
GO:0003674
GO:0005085
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005903
GO:0007165
GO:0007264
GO:0007265
GO:0008150
GO:0019899
GO:0030234
GO:0030695
GO:0043226
GO:0050790
Hs.106185.0.S2_3p_a_at
ILMN_1699856
ILMN_2297961
PH_hs_0005909
TC09002922.hg
U14417_at
g9931301_3p_a_at
Participant Of
input
Ral-GDS binds to Ras-GTP
hasComponent
Ras-GTP:RalGDS complex [plasma membrane]
hasMember
RAL GDS proteins [cytosol]
Inferred To
gefS [cytosol] (Dictyostelium discoideum)
gefC [cytosol] (Dictyostelium discoideum)
ste6 [cytosol] (Schizosaccharomyces pombe)
efc25 [cytosol] (Schizosaccharomyces pombe)
rgl-1 [cytosol] (Caenorhabditis elegans)
gefW [cytosol] (Dictyostelium discoideum)
gefD [cytosol] (Dictyostelium discoideum)
gefM [cytosol] (Dictyostelium discoideum)
BUD5 [cytosol] (Saccharomyces cerevisiae)
gefK [cytosol] (Dictyostelium discoideum)
ralgds [cytosol] (Xenopus tropicalis)
Ralgds [cytosol] (Mus musculus)
Ralgds [cytosol] (Rattus norvegicus)
gefB [cytosol] (Dictyostelium discoideum)
CDC25 [cytosol] (Saccharomyces cerevisiae)
RGL4 [cytosol] (Gallus gallus)
Rgl [cytosol] (Drosophila melanogaster)
gefY [cytosol] (Dictyostelium discoideum)
gflB [cytosol] (Dictyostelium discoideum)
RALGDS [cytosol] (Bos taurus)
RALGDS [cytosol] (Canis familiaris)
RALGDS [cytosol] (Dictyostelium discoideum)
RALGDS [cytosol] (Sus scrofa)
gefN [cytosol] (Dictyostelium discoideum)
gefE [cytosol] (Dictyostelium discoideum)
si:ch211-251j10.3 [cytosol] (Danio rerio)
Homologues of RALGDS [cytosol] (Dictyostelium discoideum)
Homologues of RALGDS [cytosol] (Saccharomyces cerevisiae)
Homologues of RALGDS [cytosol] (Schizosaccharomyces pombe)
gefO [cytosol] (Dictyostelium discoideum)
gefG [cytosol] (Dictyostelium discoideum)
gefL [cytosol] (Dictyostelium discoideum)
gefQ [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
NP_001258703.1
,
NP_006257.1
,
NP_001035827.1
,
NP_001258705.1
,
NP_001258704.1
OpenTargets
ENSG00000160271
GeneCards
Q12967
HPA
ENSG00000160271-RALGDS
Ensembl
ENSG00000160271
,
ENST00000372050
,
ENST00000372062
,
ENSP00000376864
,
ENSP00000361120
,
ENSP00000376867
,
ENST00000393160
,
ENST00000393157
,
ENSP00000361132
,
ENSP00000361117
,
ENST00000372047
PRO
Q12967
HMDB Protein
HMDBP08430
PDB
1RAX
,
2B3A
,
2RGF
,
3KH0
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01112 HRAS
23
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
proHRAS [cytosol]
(R-HSA-9647765)
S-Farn-proHRAS [endoplasmic reticulum membrane]
(R-HSA-9647918)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
0.704
3
UniProt:P61224 RAP1B
2
RAP1B [plasma membrane]
(R-HSA-377590)
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
0.573
2
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