Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RALGDS [cytosol]
Stable Identifier
R-HSA-171001
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RalGDS, Guanine-nucleotide releasing factor
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS:GTP binds RAL GDS proteins (Homo sapiens)
RAL GDS proteins [cytosol] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins [plasma membrane] (Homo sapiens)
RAL GDS proteins [cytosol] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
Guanine nucleotide exchange on RAL (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Ral-GDS binds to Ras-GTP (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens)
RALGDS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12967 RALGDS
Gene Names
RALGDS, KIAA1308, RGF
Chain
chain:1-914
Reference Genes
BioGPS Gene:5900 RALGDS
COSMIC (genes):RALGDS RALGDS
CTD Gene:5900 RALGDS
dbSNP Gene:5900 RALGDS
ENSEMBL:ENSG00000160271 RALGDS
HGNC:9842 RALGDS
KEGG Gene (Homo sapiens):5900 RALGDS
Monarch:5900 RALGDS
NCBI Gene:5900 RALGDS
OMIM:601619 RALGDS
UCSC:Q12967 RALGDS
Reference Transcript
RefSeq:NM_001042368.2 RALGDS
RefSeq:NM_001271775.1 RALGDS
RefSeq:NM_001271776.1 RALGDS
RefSeq:NM_001271774.1 RALGDS
RefSeq:NM_006266.3 RALGDS
Other Identifiers
0005690711
11737952_a_at
11741359_a_at
11741360_x_at
11752122_a_at
11757908_x_at
17099403
209050_s_at
209051_s_at
3228464
3228465
3228471
3228475
3228477
3228479
3228480
3228481
3228484
3228485
3228487
3228488
3228489
3228490
3228491
3228492
3228493
3228495
3228497
3228498
3228500
3228501
3228509
3228510
3228516
3228517
3228518
3228522
34254_at
5900
8164810
91384_at
GE503857
GO:0000165
GO:0003674
GO:0005085
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005903
GO:0006464
GO:0007165
GO:0007264
GO:0007265
GO:0008150
GO:0019899
GO:0030234
GO:0030695
GO:0043226
GO:0050790
HMNXSV003048189
Hs.106185.0.S2_3p_a_at
ILMN_1699856
ILMN_2297961
PH_hs_0005909
TC09002922.hg
U14417_at
g9931301_3p_a_at
Participates
as a component of
Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens)
as an input of
Ral-GDS binds to Ras-GTP (Homo sapiens)
as a member of
RAL GDS proteins [cytosol] (Homo sapiens)
Inferred To
gefA [cytosol]
(Dictyostelium discoideum)
gefS [cytosol]
(Dictyostelium discoideum)
gefJ [cytosol]
(Dictyostelium discoideum)
gefC [cytosol]
(Dictyostelium discoideum)
ste6 [cytosol]
(Schizosaccharomyces pombe)
efc25 [cytosol]
(Schizosaccharomyces pombe)
gefH [cytosol]
(Dictyostelium discoideum)
rgl-1 [cytosol]
(Caenorhabditis elegans)
gefW [cytosol]
(Dictyostelium discoideum)
gefD [cytosol]
(Dictyostelium discoideum)
gefM [cytosol]
(Dictyostelium discoideum)
gefP [cytosol]
(Dictyostelium discoideum)
BUD5 [cytosol]
(Saccharomyces cerevisiae)
gefF [cytosol]
(Dictyostelium discoideum)
gefK [cytosol]
(Dictyostelium discoideum)
ralgds [cytosol]
(Xenopus tropicalis)
Ralgds [cytosol]
(Mus musculus)
Ralgds [cytosol]
(Rattus norvegicus)
gefR [cytosol]
(Dictyostelium discoideum)
gefI [cytosol]
(Dictyostelium discoideum)
gefB [cytosol]
(Dictyostelium discoideum)
CDC25 [cytosol]
(Saccharomyces cerevisiae)
LTE1 [cytosol]
(Saccharomyces cerevisiae)
RGL4 [cytosol]
(Gallus gallus)
Rgl [cytosol]
(Drosophila melanogaster)
gefY [cytosol]
(Dictyostelium discoideum)
gflB [cytosol]
(Dictyostelium discoideum)
RALGDS [cytosol]
(Bos taurus)
RALGDS [cytosol]
(Canis familiaris)
RALGDS [cytosol]
(Dictyostelium discoideum)
RALGDS [cytosol]
(Sus scrofa)
gefN [cytosol]
(Dictyostelium discoideum)
gefE [cytosol]
(Dictyostelium discoideum)
si:ch211-251j10.3 [cytosol]
(Danio rerio)
gefV [cytosol]
(Dictyostelium discoideum)
Homologues of RALGDS [cytosol]
(Dictyostelium discoideum)
Homologues of RALGDS [cytosol]
(Saccharomyces cerevisiae)
Homologues of RALGDS [cytosol]
(Schizosaccharomyces pombe)
gefO [cytosol]
(Dictyostelium discoideum)
gefG [cytosol]
(Dictyostelium discoideum)
gefL [cytosol]
(Dictyostelium discoideum)
gefQ [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_006257.1
,
NP_001035827.1
,
NP_001258703.1
,
NP_001258704.1
,
NP_001258705.1
OpenTargets
ENSG00000160271
GeneCards
Q12967
HPA
ENSG00000160271-RALGDS
Ensembl
ENST00000393160
,
ENST00000393157
,
ENSP00000361132
,
ENST00000372062
,
ENSP00000361117
,
ENST00000372047
,
ENST00000372050
,
ENSP00000376867
,
ENSP00000361120
,
ENSP00000376864
,
ENSG00000160271
PRO
Q12967
Pharos - Targets
Q12967
GlyGen
Q12967
HMDB Protein
HMDBP08430
PDB
2RGF
,
3KH0
,
1RAX
,
2B3A
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01112 HRAS
20
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS [plasma membrane]
(R-HSA-62717)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
0.683
3
UniProt:P61224 RAP1B
2
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
RAP1B [plasma membrane]
(R-HSA-377590)
0.573
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
