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DELE1(143-515) [cytosol]
Stable Identifier
R-HSA-9840380
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
S-DELE1, fullName evidence="12"DAP3-binding cell death enhancer 1, DELE1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to mitochondrial stress (Homo sapiens)
DELE1(143-515) binds EIF2AK1 (HRI) (Homo sapiens)
DELE1(143-515) [cytosol] (Homo sapiens)
DELE1(143-515):EIF2AK1 [cytosol] (Homo sapiens)
DELE1(143-515) [cytosol] (Homo sapiens)
DELE1(143-515) is released into the cytosol (Homo sapiens)
DELE1(143-515) [cytosol] (Homo sapiens)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)
DELE1(143-515):EIF2AK1 [cytosol] (Homo sapiens)
DELE1(143-515) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14154 DELE1
Gene Names
DELE1, DELE, KIAA0141
Chain
transit peptide:1-23, propeptide:24-101, chain:102-515, chain:143-515
Reference Genes
BioGPS Gene:9812 DELE1
COSMIC (genes):DELE1 DELE1
CTD Gene:9812 DELE1
dbSNP Gene:9812 DELE1
ENSEMBL:ENSG00000081791 KIAA0141
HGNC:28969 DELE1
KEGG:hsa:9812 DELE1
Monarch:9812 DELE1
NCBI Gene:9812 DELE1
OMIM:615741 DELE1
UCSC:Q14154 DELE1
Reference Transcript
RefSeq:XM_005268547.3 DELE1
RefSeq:NM_001142603.2 DELE1
RefSeq:NM_014773.4 DELE1
RefSeq:XM_005268548.3 DELE1
Other Identifiers
11717031_a_at
11717032_at
11717033_a_at
11717034_a_at
11717035_s_at
16990401
201977_PM_s_at
201977_s_at
201978_PM_s_at
201978_s_at
227056_PM_at
227056_at
238659_PM_at
238659_at
2832966
2832967
2832968
2832969
2832970
2832971
2832972
2832975
2832978
2832979
2832980
2832983
2832985
2832986
2832987
2832988
2832989
2832990
2832991
2832992
2832995
2832996
2832997
2832998
2832999
2833000
2833001
2833002
2833003
2833004
2833005
2833006
2833007
2833008
2833009
2833010
2833011
2833013
35744_at
48358_at
65143_at
8108832
9812
A_14_P102723
A_23_P213369
A_24_P63563
D50931_at
GE57261
GE783541
GO:0005515
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005829
GO:0006915
GO:0006974
GO:0008625
GO:0012501
GO:0043226
GO:0043539
GO:0098772
GO:0140468
GO:1901526
GO:1990641
HMNXSV003010980
HMNXSV003029377
HMNXSV003038962
Hs.63510.0.A1_3p_a_at
Hs.63510.1.A1_3p_at
Hs.92418.0.A1_3p_at
Hs.92418.0.A1_3p_x_at
ILMN_1762990
ILMN_1881299
PH_hs_0023064
TC05000775.hg
g7661939_3p_a_at
Participates
as an input of
DELE1(143-515) binds EIF2AK1 (HRI) (Homo sapiens)
as a component of
DELE1(143-515):EIF2AK1 [cytosol] (Homo sapiens)
as an output of
DELE1(143-515) is released into the cytosol (Homo sapiens)
Other forms of this molecule
DELE1 [mitochondrial inner membrane]
DELE1(143-515) [mitochondrial inner membrane]
Inferred To
dele1 [cytosol]
(Danio rerio)
dele1 [cytosol]
(Xenopus tropicalis)
Dele1 [cytosol]
(Mus musculus)
Dele1 [cytosol]
(Rattus norvegicus)
DELE1 [cytosol]
(Bos taurus)
DELE1 [cytosol]
(Canis familiaris)
DELE1 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000432126
,
ENST00000194118
,
ENSP00000194118
,
ENSP00000396225
OpenTargets
ENSG00000081791
HPA
ENSG00000081791-DELE1
PRO
Q14154
Pharos - Targets
Q14154
PDB
8D9X
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13449 LSAMP
2
cleaved GPI-LSAMP [extracellular region]
(R-HSA-8941032)
GPI-LSAMP [plasma membrane]
(R-HSA-8940809)
0.556
3
UniProt:O14656-2 TOR1A
0.556
3
UniProt:Q9BVL2 NUP58
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.556
3
UniProt:P28331-2 NDUFS1
0.556
3
UniProt:O14901 KLF11
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:O43186 CRX
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:P15056 BRAF
20
p-S,T-BRAF [cytosol]
(R-HSA-169856)
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
0.527
2
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