Reactome | MAPK11 [nucleoplasm]

MAPK11 [nucleoplasm]

Stable Identifier

R-HSA-203790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MAP kinase p38 beta

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External Reference Information

External Reference

UniProt:Q15759 MAPK11

Gene Names

MAPK11, PRKM11, SAPK2, SAPK2B

Chain

chain:1-364

Reference Genes

BioGPS Gene:5600 MAPK11

COSMIC (genes):MAPK11 MAPK11

CTD Gene:5600 MAPK11

dbSNP Gene:5600 MAPK11

ENSEMBL:ENSG00000185386 MAPK11

HGNC:6873 MAPK11

KEGG Gene (Homo sapiens):5600 MAPK11

Monarch:5600 MAPK11

NCBI Gene:5600 MAPK11

OMIM:602898 MAPK11

UCSC:Q15759 MAPK11

Reference Transcript

RefSeq:NM_002751.6 MAPK11

Other Identifiers

0001340017

0006840121

1010_at

11730965_a_at

11730966_at

16936432

206040_s_at

211499_s_at

211500_at

3965783

3965785

3965786

3965787

3965788

3965789

3965790

3965791

3965793

3965795

3965797

3965798

3965800

3965801

3965802

3965803

3965804

3965805

3965806

3965807

3965808

40033_at

5600

8076978

A_23_P502274

A_33_P3409508

A_33_P3409513

GE88364

GO:0000166

GO:0000187

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0007265

GO:0008150

GO:0008283

GO:0009058

GO:0010468

GO:0010628

GO:0016301

GO:0016310

GO:0016740

GO:0030154

GO:0032735

GO:0034641

GO:0035556

GO:0040007

GO:0043167

GO:0043226

GO:0048010

GO:0048856

GO:0051090

GO:0051149

GO:0051403

GO:0060043

GO:0060044

GO:0071347

GO:0098586

GO:1901796

HMNXSV003058003

ILMN_1724715

ILMN_1735361

PH_hs_0003700

TC22000910.hg

U53442_at

g1469305_3p_at

g1469305_3p_x_at

g2316011_3p_a_at

g4506082_3p_a_at

Participates

as a member of

MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MAPK11 [cytosol]

p-T180,Y182-MAPK11 [cytosol]

p-T180,Y182-MAPK11 [nucleoplasm]

Inferred To

p38c [nucleoplasm] (Drosophila melanogaster)

p38a [nucleoplasm] (Drosophila melanogaster)

pmk-1 [nucleoplasm] (Caenorhabditis elegans)

p38b [nucleoplasm] (Drosophila melanogaster)

mapk11 [nucleoplasm] (Danio rerio)

MAPK11 [nucleoplasm] (Bos taurus)

MAPK11 [nucleoplasm] (Sus scrofa)

pmk-2 [nucleoplasm] (Caenorhabditis elegans)

Mapk11 [nucleoplasm] (Mus musculus)

Mapk11 [nucleoplasm] (Rattus norvegicus)

Homologues of MAPK11 [nucleoplasm] (Caenorhabditis elegans)

Homologues of MAPK11 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002742.3

ZINC - World Drugs

MK11_HUMAN

OpenTargets

ENSG00000185386

ZINC - FDA approved

MK11_HUMAN

ZINC - Substances

MK11_HUMAN

ZINC target

Q15759

PRO

Q15759

PDB

3GC9, 3GC8, 3GP0

ZINC - Investigational

MK11_HUMAN

IntEnz

2.7.11.24

GeneCards

Q15759

HPA

ENSG00000185386-MAPK11

Ensembl

ENST00000395764, ENSP00000379113, ENSG00000185386, ENST00000330651, ENSP00000333685

ZINC - Predictions - Purchasable

MK11_HUMAN

HMDB Protein

HMDBP01336

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P17252 PRKCA	8	p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [cytosol] (R-HSA-58196) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) PRKCA [plasma membrane] (R-HSA-156469) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:Q13153 PAK1	6	p-S144-PAK1 [cytosol] (R-HSA-451339) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.556	3
UniProt:Q16539 MAPK14	7	MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [nucleoplasm] (R-HSA-446223) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.547	2

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