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MAPK11 [nucleoplasm]
Stable Identifier
R-HSA-203790
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MAP kinase p38 beta
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)
p38 MAPK:MAPKAPK5 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK11 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15759 MAPK11
Gene Names
MAPK11, PRKM11, SAPK2, SAPK2B
Chain
chain:1-364
Reference Genes
BioGPS Gene:5600 MAPK11
COSMIC (genes):MAPK11 MAPK11
CTD Gene:5600 MAPK11
dbSNP Gene:5600 MAPK11
ENSEMBL:ENSG00000185386 MAPK11
HGNC:6873 MAPK11
KEGG Gene (Homo sapiens):5600 MAPK11
Monarch:5600 MAPK11
NCBI Gene:5600 MAPK11
OMIM:602898 MAPK11
UCSC:Q15759 MAPK11
Reference Transcript
RefSeq:NM_002751.6 MAPK11
Other Identifiers
0001340017
0006840121
1010_at
11730965_a_at
11730966_at
16936432
206040_PM_s_at
206040_s_at
211499_PM_s_at
211499_s_at
211500_PM_at
211500_at
3965783
3965785
3965786
3965787
3965788
3965789
3965790
3965791
3965793
3965795
3965797
3965798
3965800
3965801
3965802
3965803
3965804
3965805
3965806
3965807
3965808
40033_at
5600
8076978
A_23_P502274
A_33_P3409508
A_33_P3409513
GE88364
GO:0000165
GO:0000166
GO:0001649
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007568
GO:0008150
GO:0008283
GO:0010628
GO:0016301
GO:0016310
GO:0016740
GO:0030154
GO:0032735
GO:0035556
GO:0038066
GO:0040007
GO:0043167
GO:0043226
GO:0048856
GO:0051149
GO:0051403
GO:0060043
GO:0060044
GO:0060348
GO:0071347
GO:0090398
GO:0098586
GO:0106310
HMNXSV003058003
ILMN_1724715
ILMN_1735361
PH_hs_0003700
TC22000910.hg
U53442_at
g1469305_3p_at
g1469305_3p_x_at
g2316011_3p_a_at
g4506082_3p_a_at
Participates
as a member of
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T180,Y182-MAPK11 [cytosol]
MAPK11 [cytosol]
p-T180,Y182-MAPK11 [nucleoplasm]
Inferred To
pmk-3 [nucleoplasm]
(Caenorhabditis elegans)
p38c [nucleoplasm]
(Drosophila melanogaster)
p38a [nucleoplasm]
(Drosophila melanogaster)
pmk-1 [nucleoplasm]
(Caenorhabditis elegans)
p38b [nucleoplasm]
(Drosophila melanogaster)
mapk11 [nucleoplasm]
(Danio rerio)
mapk11 [nucleoplasm]
(Xenopus tropicalis)
MAPK11 [nucleoplasm]
(Bos taurus)
MAPK11 [nucleoplasm]
(Canis familiaris)
MAPK11 [nucleoplasm]
(Sus scrofa)
pmk-2 [nucleoplasm]
(Caenorhabditis elegans)
Mapk11 [nucleoplasm]
(Mus musculus)
Mapk11 [nucleoplasm]
(Rattus norvegicus)
Homologues of MAPK11 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of MAPK11 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002742.3
ZINC - World Drugs
MK11_HUMAN
Guide to Pharmacology - Targets
1500
OpenTargets
ENSG00000185386
ZINC - FDA approved
MK11_HUMAN
ZINC - Substances
MK11_HUMAN
ZINC target
Q15759
PRO
Q15759
PDB
3GC9
,
3GC8
,
3GP0
ZINC - Investigational
MK11_HUMAN
IntEnz
2.7.11.24
GeneCards
Q15759
HPA
ENSG00000185386-MAPK11
Ensembl
ENSG00000185386
,
ENST00000330651
,
ENSP00000333685
,
ENST00000395764
,
ENSP00000379113
Pharos - Targets
Q15759
ZINC - Predictions - Purchasable
MK11_HUMAN
HMDB Protein
HMDBP01336
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [plasma membrane]
(R-HSA-156469)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.556
3
UniProt:Q13153 PAK1
6
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144-PAK1 [cytosol]
(R-HSA-451339)
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.556
3
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.547
2
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