Reactome | E2F2 [nucleoplasm]

E2F2 [nucleoplasm]

Stable Identifier

R-HSA-68649

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor E2F2, E2F-2

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1 Phase (Homo sapiens)
      - Cyclin D associated events in G1 (Homo sapiens)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
        
        E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
        
        E2F1/2/3 [nucleoplasm] (Homo sapiens)
        
        E2F2 [nucleoplasm] (Homo sapiens)
        
        RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2: [nucleoplasm] (Homo sapiens)
        
        E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
        
        E2F1/2/3 [nucleoplasm] (Homo sapiens)
        
        E2F2 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        E2F1,(E2F2,E2F3):TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
        
        E2F1,(E2F2,E2F3) [nucleoplasm] (Homo sapiens)
        
        E2F2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14209 E2F2

Gene Names

E2F2

Chain

chain:1-437

Reference Genes

BioGPS Gene:1870 E2F2

COSMIC (genes):E2F2 E2F2

CTD Gene:1870 E2F2

dbSNP Gene:1870 E2F2

ENSEMBL:ENSG00000007968 E2F2

ENSEMBL:ENSG00000007968.7 E2F2

ENSEMBL:ENSG00000282899.2 E2F2

HGNC:3114 E2F2

KEGG Gene (Homo sapiens):1870 E2F2

Monarch:1870 E2F2

NCBI Gene:1870 E2F2

OMIM:600426 E2F2

UCSC:Q14209 E2F2

Reference Transcript

RefSeq:NM_004091.3 E2F2

Other Identifiers

0005220497

11724078_at

11724079_s_at

16683358

16808717

1870

2068_s_at

207042_PM_at

207042_at

228361_PM_at

228361_at

235582_PM_at

235582_at

2401447

2401449

2401450

2401452

2401453

2401454

2401455

2401456

2401457

2401462

2401463

2401467

2401468

2401469

2401476

2401477

2401478

2401480

3203077

53663_at

73591_at

7913644

84129_at

A_23_P125990

A_23_P408955

GE574933

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0006367

GO:0007049

GO:0012501

GO:0023052

GO:0032991

GO:0043226

GO:0043565

GO:0045944

GO:0046983

GO:0048856

GO:0051726

GO:0072332

GO:0090575

GO:1903671

GO:1990086

GO:1990837

HMNXSV003000079

Hs.231444.0.A1_3p_at

Hs.49047.0.A1_3p_at

ILMN_1777233

PH_hs_0012692

TC01002345.hg

g4758225_3p_at

g4758225_3p_x_at

Participates

as a candidate of

E2F1,(E2F2,E2F3) [nucleoplasm] (Homo sapiens)

as a member of

E2F1/2/3 [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of E2F2 [nucleoplasm] (Danio rerio)

E2f2 [nucleoplasm] (Mus musculus)

E2f2 [nucleoplasm] (Rattus norvegicus)

e2f3 [nucleoplasm] (Xenopus tropicalis)

E2f1 [nucleoplasm] (Drosophila melanogaster)

E2F1 [nucleoplasm] (Dictyostelium discoideum)

E2F2 [nucleoplasm] (Bos taurus)

E2F2 [nucleoplasm] (Canis familiaris)

E2F2 [nucleoplasm] (Danio rerio)

E2F2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004082.1

OpenTargets

ENSG00000007968

GeneCards

Q14209

HPA

ENSG00000007968-E2F2

Ensembl

ENST00000634683, ENSP00000355249, ENSP00000489612, ENST00000361729, ENSG00000007968, ENSG00000282899

PRO

Q14209

Pharos - Targets

Q14209

PDB

1N4M

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.78	5
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.659	3