Reactome | p-Y-JAK3 [cytosol]

p-Y-JAK3 [cytosol]

Stable Identifier

R-HSA-9006854

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase JAK3, JAK3_HUMAN, Janus kinase 3

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin-15 signaling (Homo sapiens)
        
        IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL2RB and IL2RG are phosphorylated (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
      - Interleukin-21 signaling (Homo sapiens)
        
        IL21 receptor JAK phosphorylation (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL21 receptor STAT binding (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL21 receptor STAT phosphorylation (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Homo sapiens)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
        
        p-Y-JAK3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52333 JAK3

Gene Names

JAK3

Chain

chain:1-1124

Reference Genes

BioGPS Gene:3718 JAK3

COSMIC (genes):JAK3 JAK3

CTD Gene:3718 JAK3

dbSNP Gene:3718 JAK3

ENSEMBL:ENSG00000105639 JAK3

HGNC:6193 JAK3

KEGG:hsa:3718 JAK3

Monarch:3718 JAK3

NCBI Gene:3718 JAK3

OMIM:600173 JAK3

UCSC:P52333 JAK3

Reference Transcript

RefSeq:NM_000215.3 JAK3

Other Identifiers

11727257_a_at

11750098_a_at

11750573_x_at

11752613_a_at

11761631_at

1547_at

16870274

2005_s_at

2006_at

2007_g_at

207187_3p_at

207187_PM_at

207187_at

211108_PM_s_at

211108_s_at

211109_PM_at

211109_at

227677_PM_at

227677_at

3718

3854628

3854629

3854630

3854631

3854632

3854633

3854634

3854635

3854636

3854638

3854639

3854640

3854641

3854642

3854643

3854644

3854645

3854646

3854647

3854648

3854649

3854650

3854651

3854652

3854653

3854655

3854656

3854657

3854658

3854659

3854660

3854661

3854662

3854663

3854664

3854665

3854667

46152_at

8035351

A_23_P329112

A_24_P308096

A_24_P59667

GE58907

GO:0002250

GO:0002376

GO:0002731

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005131

GO:0005515

GO:0005524

GO:0005737

GO:0005768

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0007167

GO:0007259

GO:0007260

GO:0009898

GO:0012505

GO:0016020

GO:0016301

GO:0016740

GO:0018108

GO:0019221

GO:0019897

GO:0019903

GO:0030154

GO:0030183

GO:0031234

GO:0031410

GO:0032693

GO:0032695

GO:0035556

GO:0035723

GO:0035771

GO:0038110

GO:0038111

GO:0038113

GO:0042981

GO:0043029

GO:0043226

GO:0045087

GO:0045221

GO:0045626

GO:0046425

GO:0050868

GO:0060397

GO:0070232

GO:0070244

GO:0070669

GO:0070670

GO:0070672

GO:0071104

GO:0098542

GO:0140096

GO:2000329

HMNXSV003018899

HMNXSV003045226

Hs.58643.0.A1_3p_at

ILMN_1739667

PH_hs_0023062

PH_hs_0032182

TC19001280.hg

U09607_at

g1039418_3p_at

g4557680_3p_at

Participates

as a component of

Other forms of this molecule

JAK3 [cytosol]

p-JAK3 [cytosol]

JAK3 [endosome]

p-Y904,939-JAK3 [plasma membrane]

p-Y980 JAK3 [cytosol]

Inferred To

phospho-p-Y-JAK3 [cytosol] (Bos taurus)

phospho-p-Y-JAK3 [cytosol] (Canis familiaris)

phospho-p-Y-JAK3 [cytosol] (Mus musculus)

phospho-p-Y-JAK3 [cytosol] (Rattus norvegicus)

phospho-p-Y-JAK3 [cytosol] (Sus scrofa)

Ghost homologue of p-Y-JAK3 [cytosol] (Danio rerio)

Ghost homologue of p-Y-JAK3 [cytosol] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_000206.2

ZINC - World Drugs

JAK3_HUMAN

Guide to Pharmacology - Targets

2049

OpenTargets

ENSG00000105639

ENSEMBL

ENSP00000436421, ENST00000458235, ENSP00000432511, ENST00000527670, ENSP00000391676, ENST00000534444

ZINC - FDA approved

JAK3_HUMAN

ZINC - Substances

JAK3_HUMAN

ZINC - Biogenic

JAK3_HUMAN

ZINC target

P52333

PRO

P52333

PDB

6DA4, 7APG, 7APF, 4QPS, 4HVG, 3PJC, 6HZV, 5LWN, 6NY4, 4HVH, 6GL9, 6DB3, 5TTS, 5LWM, 4QT1, 7Q6H, 4RIO, 6AAK, 3LXK, 3ZEP, 6DB4, 3LXL, 4HVD, 4Z16, 4V0G, 7C3N, 5TOZ, 5TTV, 8EXM, 5W86, 5TTU, 5VO6, 4I6Q, 6DUD, 5WFJ, 4HVI, 1YVJ, 3ZC6, 6GLB, 6GLA, 7UYV

ZINC - Investigational

JAK3_HUMAN

HPA

ENSG00000105639-JAK3

Pharos - Targets

P52333

Orphanet

JAK3

ZINC - Predictions - Purchasable

JAK3_HUMAN

HMDB Protein

HMDBP01358

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNF1 MAGED2	2	MAGED2 [extracellular region] (R-HSA-8862948) MAGED2 [platelet alpha granule lumen] (R-HSA-8862956)	0.623	4
UniProt:P55209 NP1L1			0.623	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:Q5JWF2 GNAS	1	GNAS1 [plasma membrane] (R-HSA-8873940)	0.527	2
UniProt:Q99733 NP1L4			0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	2
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [cytosol] (R-HSA-390449)	0.527	2
UniProt:O95071 UBR5			0.527	2
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2

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