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INHBA [extracellular region]
Stable Identifier
R-HSA-205926
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Human Activin A chain, Human Activin A
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Glycoprotein hormones (Homo sapiens)
Follitropin is a heterodimer (Homo sapiens)
ACTIVIN [extracellular region] (Homo sapiens)
heteroINHB [extracellular region] (Homo sapiens)
INHBs [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
homoINHB [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHIB [extracellular region] (Homo sapiens)
INHBs [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
Activin AB,B [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane] (Homo sapiens)
Activin AB,B [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)
Activin AB,B [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
Activin AB,B [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Antagonism of Activin by Follistatin (Homo sapiens)
FSTL3 binds Activin (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin A,AB,B:FSTL3 [extracellular region] (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Follistatin (FST) binds Activin (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin A,AB,B:FST [extracellular region] (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Homo sapiens)
Activin A,AB,B [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane] (Homo sapiens)
Activin AB,B [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Signaling by BMP (Homo sapiens)
BMP2 binds to the receptor complex (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 regulates activin signaling (Homo sapiens)
Inhibin-A binding to TGFBR3 (Homo sapiens)
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
InhibinA-TGFBR3 binding to ACVR2A (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3 [plasma membrane] (Homo sapiens)
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08476 INHBA
Gene Names
INHBA
Chain
signal peptide:1-20, propeptide:21-310, chain:311-426
Reference Genes
BioGPS Gene:3624 INHBA
COSMIC (genes):INHBA INHBA
CTD Gene:3624 INHBA
dbSNP Gene:3624 INHBA
ENSEMBL:ENSG00000122641 INHBA
HGNC:6066 INHBA
KEGG:hsa:3624 INHBA
Monarch:3624 INHBA
NCBI Gene:3624 INHBA
OMIM:147290 INHBA
UCSC:P08476 INHBA
Reference Transcript
RefSeq:NM_002192.3 INHBA
RefSeq:XM_017012174.1 INHBA
RefSeq:XM_017012176.1 INHBA
Other Identifiers
11731496_at
11746931_a_at
1203_at
17056980
17056984
204926_at
210511_PM_s_at
210511_s_at
227140_PM_at
227140_at
3047573
3047574
3047575
3047576
3047577
3047578
3047580
3047582
3047583
3047584
3047585
3047586
3047587
3047589
3047590
3047591
3047592
3047593
3047594
3047596
3047597
3047598
3047599
3047600
3047617
3047619
3047621
3624
40357_at
65626_at
8139207
A_23_P122924
A_24_P535256
D17357_at
GE57486
GE746940
GO:0001541
GO:0001707
GO:0001942
GO:0002244
GO:0005102
GO:0005125
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006629
GO:0006694
GO:0006914
GO:0006952
GO:0007166
GO:0007267
GO:0007399
GO:0008083
GO:0008209
GO:0008285
GO:0008584
GO:0010467
GO:0010628
GO:0017046
GO:0019221
GO:0021773
GO:0022414
GO:0023052
GO:0030154
GO:0030218
GO:0030308
GO:0032689
GO:0032924
GO:0032967
GO:0035987
GO:0042326
GO:0042476
GO:0042541
GO:0042701
GO:0042802
GO:0043509
GO:0043512
GO:0044877
GO:0045578
GO:0045648
GO:0045650
GO:0045893
GO:0045944
GO:0045945
GO:0046880
GO:0046881
GO:0046882
GO:0048018
GO:0048333
GO:0048471
GO:0048856
GO:0051247
GO:0051799
GO:0060021
GO:0060279
GO:0060391
GO:0060395
GO:0060936
GO:0061029
GO:0070374
GO:0070699
GO:0071372
GO:0071397
GO:0071456
GO:0090650
GO:0097154
GO:0097191
GO:0098772
GO:0150005
GO:1903449
GO:1904044
GO:1904385
GO:2000134
GO:2001241
HMNXSV003011526
HMNXSV003034371
Hs.28792.0.S1_3p_at
ILMN_1719547
PH_hs_0031121
TC07001317.hg
TC07001318.hg
TC07002911.hg
X57579_s_at
g186414_3p_a_at
g4504698_3p_at
p14920
Participates
as a member of
INHBs [extracellular region] (Homo sapiens)
as a component of
INHIBIN-A [extracellular region] (Homo sapiens)
INHBA:INHBB [extracellular region] (Homo sapiens)
INHBA dimer [extracellular region] (Homo sapiens)
Inferred To
inhba [extracellular region]
(Xenopus tropicalis)
Inhba [extracellular region]
(Mus musculus)
Inhba [extracellular region]
(Rattus norvegicus)
INHBA [extracellular region]
(Bos taurus)
INHBA [extracellular region]
(Canis familiaris)
INHBA [extracellular region]
(Gallus gallus)
INHBA [extracellular region]
(Sus scrofa)
inhbab [extracellular region]
(Danio rerio)
Actbeta [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016867663.1
,
NP_002183.1
,
XP_016867665.1
ENSEMBL
ENST00000442711
,
ENSP00000490646
,
ENSP00000397197
,
ENSP00000242208
,
ENST00000638023
,
ENST00000242208
OpenTargets
ENSG00000122641
HPA
ENSG00000122641-INHBA
PRO
P08476
Pharos - Targets
P08476
GlyGen
P08476
Orphanet
INHBA
PDB
6Y6N
,
7U5P
,
1NYU
,
6Y6O
,
2B0U
,
3B4V
,
1NYS
,
2P6A
,
2ARV
,
2ARP
,
4MID
,
7OLY
,
1S4Y
,
5HLZ
,
5HLY
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21674
1
Fst [extracellular region]
(R-RNO-2473211)
0.558
2
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