Reactome | p-BRAF F595L [plasma membrane]

p-BRAF F595L [plasma membrane]

Stable Identifier

R-HSA-8936641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

B-RAF

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - Dissociation of moderate activity BRAF complexes (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12068308	Mutations of the BRAF gene in human cancer Maitland, N, Jayatilake, H, Futreal, PA, Yuen, ST, Marshall, CJ, Menzies, A, Parker, A, Chenevix-Trench, G, Leung, SY, Garnett, MJ, Davis, N, Shipley, J, Cooper, C, Darrow, TL, Marais, R, Paterson, H, Palmieri, G, Floyd, Y, Bottomley, W, Bigner, DD, Bignell, GR, Stevens, C, Cossu, A, Hall, S, Ho, JW, Wilson, R, Mould, C, Gusterson, BA, Watt, S, Cox, C, Riggins, GJ, Flanagan, A, Gray, K, Wooster, R, Hooper, S, Teague, J, Ewing, R, Edkins, S, Seigler, HF, Hargrave, D, Hawes, R, Kosmidou, V, Nicholson, A, Stephens, P, Weber, BL, Hughes, J, Davies, H, Woffendin, H, Stratton, MR, Clegg, S, Dicks, E, Pritchard-Jones, K	Nature	2002
16439621	Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome Tidyman, WE, McCormick, F, Cruz, MS, Conger, BA, Rodriguez-Viciana, P, Estep, AL, Rauen, KA, Tetsu, O	Science	2006
19206169	Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum Cordeddu, V, Ferrero, GB, Scioletti, AP, Tartaglia, M, Marino, B, Digilio, MC, Puxeddu, E, Moretti, S, Gelb, BD, Stuppia, L, Zampino, G, Esposito, G, Carta, C, Sarkozy, A, Pantaleoni, F, Memo, L, Mancini, GM, Petrangeli, V, Dallapiccola, B, Silengo, MC, Faravelli, F, Lepri, F, Selicorni, A, Rossi, C, Stanzial, F, Dentici, ML, Mazzanti, L	Hum. Mutat.	2009
15035987	Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Niculescu-Duvaz, D, Lee, S, Marais, R, Marshall, CJ, Barford, D, Jones, CM, Good, VM, Springer, CJ, Wan, PT, Garnett, MJ, Roe, SM	Cell	2004

External Reference Information

External Reference

UniProt:P15056 BRAF

Gene Names

BRAF, BRAF1, RAFB1

Chain

initiator methionine:, chain:2-766

Reference Genes

BioGPS Gene:673 BRAF

COSMIC (genes):BRAF BRAF

CTD Gene:673 BRAF

dbSNP Gene:673 BRAF

ENSEMBL:ENSG00000157764 BRAF

HGNC:1097 BRAF

KEGG:hsa:673 BRAF

Monarch:673 BRAF

NCBI Gene:673 BRAF

OMIM:164757 BRAF

UCSC:P15056 BRAF

Reference Transcript

RefSeq:NM_004333.4 BRAF

Other Identifiers

11732491_s_at

1654_at

17063631

206044_PM_s_at

206044_s_at

226391_PM_at

226391_at

236402_PM_at

236402_at

243829_PM_at

243829_at

3076354

3076355

3076356

3076357

3076358

3076359

3076360

3076361

3076362

3076363

3076364

3076365

3076366

3076367

3076368

3076370

3076371

3076372

3076374

3076375

3076380

3076381

3076382

3076383

3076384

3076385

3076386

3076388

3076390

3076391

3076392

3076393

3076396

3076397

3076398

3076399

3076406

3076411

3076412

3076413

3076414

3076415

3076416

3076439

3076440

3076441

3076442

3982166

3982173

40306_at

55694_at

673

72299_r_at

75931_at

8143417

86199_r_at

91686_at

A_23_P42935

A_24_P567502

GE58163

GE766137

GO:0000165

GO:0002318

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004676

GO:0004677

GO:0004679

GO:0004694

GO:0004708

GO:0004709

GO:0004711

GO:0004713

GO:0005509

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005815

GO:0005829

GO:0005886

GO:0005929

GO:0006325

GO:0006338

GO:0006468

GO:0007010

GO:0007155

GO:0007165

GO:0007173

GO:0008270

GO:0008542

GO:0009887

GO:0010628

GO:0010764

GO:0010828

GO:0012501

GO:0016079

GO:0016192

GO:0016740

GO:0030154

GO:0030878

GO:0033077

GO:0033138

GO:0034446

GO:0034451

GO:0035019

GO:0035175

GO:0035402

GO:0035403

GO:0035979

GO:0036064

GO:0036211

GO:0042127

GO:0042802

GO:0043005

GO:0043066

GO:0043149

GO:0043226

GO:0043231

GO:0043367

GO:0043368

GO:0043369

GO:0043524

GO:0044022

GO:0044023

GO:0044024

GO:0044025

GO:0044297

GO:0045580

GO:0046632

GO:0046872

GO:0048538

GO:0048679

GO:0048680

GO:0048856

GO:0050772

GO:0050852

GO:0050877

GO:0051496

GO:0060291

GO:0060323

GO:0060324

GO:0070371

GO:0070374

GO:0071277

GO:0071466

GO:0072354

GO:0072371

GO:0072518

GO:0072577

GO:0090150

GO:0097110

GO:0098793

GO:0098978

GO:0099170

GO:0106310

GO:0140096

GO:0140823

GO:0140855

GO:0140857

GO:1900026

GO:1990244

GO:2000301

GO:2000352

HMNXSV003020754

HMNXSV003038238

Hs.162967.0.A1_3p_at

Hs.299137.0.A1_3p_at

Hs.96566.0.S1_3p_at

ILMN_1652472

ILMN_1836469

M95712_at

PH_hs_0027912

PH_hs_0038106

TC07001926.hg

TC07001927.hg

TC07003197.hg

g4757867_3p_a_at

p26408

Participates

as a member of

phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

BRAF(1-380)-MACF1(600-7388)fusion [cytosol]

p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]

BRAF E501G [cytosol]

BRAF D594N [cytosol]

BRAF D638E [cytosol]

BRAF G596R [cytosol]

BRAF D594V [cytosol]

BRAF G596V [cytosol]

BRAF G466E [cytosol]

BRAF D594G [cytosol]

BRAF L505H [cytosol]

BRAF F595L [cytosol]

BRAF L597V [cytosol]

BRAF G464E [cytosol]

BRAF N581D [cytosol]

BRAF E586K [cytosol]

BRAF V600K [cytosol]

BRAF A246P [cytosol]

BRAF G469V [cytosol]

BRAF T244P [cytosol]

BRAF G469R [cytosol]

BRAF L597R [cytosol]

BRAF G469E [cytosol]

BRAF L597Q [cytosol]

BRAF G466A [cytosol]

BRAF G466V [cytosol]

BRAF N581S [cytosol]

BRAF G464V [cytosol]

p-BRAF L597V [plasma membrane]

p-BRAF L505H [plasma membrane]

p-BRAF G464E [plasma membrane]

p-BRAF A246P [plasma membrane]

p-BRAF E586K [plasma membrane]

p-BRAF N581D [plasma membrane]

p-BRAF V600K [plasma membrane]

p-BRAF G464V [plasma membrane]

p-BRAF T244P [plasma membrane]

p-BRAF G469E [plasma membrane]

p-BRAF G466V [plasma membrane]

p-BRAF G469V [plasma membrane]

p-BRAF G466A [plasma membrane]

p-BRAF L597Q [plasma membrane]

p-BRAF L597R [plasma membrane]

p-BRAF N581S [plasma membrane]

p-BRAF G469R [plasma membrane]

BRAF T599dup [cytosol]

p-S446,T599,S602,S729 BRAF [cytosol]

p-S446,S729-BRAF [cytosol]

p-S446,T599,S602,S729 BRAF [plasma membrane]

BRAF [cytosol]

p-S,T-BRAF [cytosol]

p-S365,S446,S729 BRAF [cytosol]

hyperphosphorylated BRAF [plasma membrane]

p-S446,S729-BRAF [plasma membrane]

BRAF V600E;V169_D380del [cytosol]

BRAF V600E;V47_M438del [cytosol]

BRAF V600E;V47_D380del [cytosol]

BRAF V600E;V169_M438del [cytosol]

BRAF K601E [cytosol]

BRAF V600E [cytosol]

BRAF K499E [cytosol]

BRAF Q257R [cytosol]

BRAF L485F [cytosol]

BRAF G469A [cytosol]

BRAF K601N [cytosol]

BRAF S467A [cytosol]

BRAF G534R [cytosol]

Modified Residues

Name

L-phenylalanine 595 replaced with L-leucine

Coordinate

595

PsiMod

L-leucine residue [MOD:00020]

A protein modification that effectively converts a source amino acid residue to an L-leucine.

L-phenylalanine removal [MOD:01644]

A protein modification that effectively removes or replaces an L-phenylalanine.

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 599

Coordinate

599

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 602

Coordinate

602

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
LEOPARD syndrome	DOID:14291	Generalized lentiginosis, Multiple lentigines syndrome, Moynahan syndrome, Cardiocutaneous syndrome, Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome, Lentiginosis profusa syndrome, Gorlin syndrome II, Progressive cardiomyopathic lentiginosis
cardiofaciocutaneous syndrome	DOID:0060233	CFC syndrome, cardio-facial-cutaneous syndrome
bladder carcinoma	DOID:4007	carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
colorectal cancer	DOID:9256
Noonan syndrome	DOID:3490	Turner's phenotype, karyotype normal (disorder)

Cross References

RefSeq

NP_004324.2

ZINC - World Drugs

BRAF_HUMAN

Guide to Pharmacology - Targets

1943

ClinGen

CA295915, CA280071, CA280058

OpenTargets

ENSG00000157764

ENSEMBL

ENSG00000157764, ENST00000646891, ENSP00000493543

ZINC - FDA approved

BRAF_HUMAN

ZINC - Substances

BRAF_HUMAN

ZINC - Biogenic

BRAF_HUMAN

ZINC target

P15056

PRO

P15056

PDB

4CQE, 3Q4C, 5CSW, 4H58, 7M0X, 8QQG, 6N0P, 7ZR5, 7M0W, 5HI2, 2L05, 4XV2, 6P3D, 4FK3, 4EHE, 6V2U, 6UAN, 4EHG, 6V2W, 9BFB, 3PRI, 9AXX, 5VAL, 5JRQ, 7MFF, 7P3V, 5HIE, 1UWJ, 4MNE, 8F7O, 7M0T, 4XV1, 3PSD, 5J18, 6XLO, 4E26, 7K0V, 4KSQ, 7ZR6, 8DGS, 3C4C, 6U2H, 6V34, 4RZV, 3D4Q, 3SKC, 8C7X, 4XV9, 4DBN, 4MBJ, 9AXY, 3NY5, 6NSQ, 5HID, 2FB8, 4MNF, 6NYB, 5CT7, 8F7P, 5CSX, 7M0U, 3II5, 3IDP, 7M0Y, 8DGT, 4E4X, 3PPK, 4KSP, 4RZW, 6U2G, 4XV3, 6P7G, 5JT2, 5JSM, 8C7Y, 5J2R, 7M0Z, 4WO5, 5FD2, 3PRF, 7MFD, 6UUO, 6XFP, 6XAG, 6Q0K, 1UWH, 3TV6, 7SHV, 3PSB, 4R5Y, 6B8U, 5J17, 5VYK, 7ZR0, 3PPJ, 7M0V, 6N0Q, 4YHT, 4FC0, 4G9C, 4JVG, 6PP9, 3OG7, 5C9C, 5VR3, 3TV4, 5ITA, 6CAD, 5VAM, 6Q0J, 3Q96, 6Q0T, 7MFE, 4PP7, 4G9R

ZINC - Investigational

BRAF_HUMAN

ZINC - Metabolites

BRAF_HUMAN

COSMIC

COSV56088678, COSV56127790

GeneCards

BRAF

HPA

ENSG00000157764-BRAF

Pharos - Targets

P15056

Orphanet

BRAF

ZINC - Predictions - Purchasable

BRAF_HUMAN

HMDB Protein

HMDBP02597

Interactors (127)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.98	65
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.968	73
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.941	15
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.932	14
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) proHRAS [cytosol] (R-HSA-9647765) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.931	9
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.927	14
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.912	12
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.908	12
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.894	13
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.889	9
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.889	11
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.879	12
UniProt:P01111 NRAS	20	S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) proNRAS [cytosol] (R-HSA-9647758) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) NRAS [plasma membrane] (R-HSA-62725) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12V [plasma membrane] (R-HSA-9649666)	0.863	8
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.767	6
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.731	5
UniProt:Q8N122 RPTOR	3	p-S722,S792-RPTOR [cytosol] (R-HSA-3132767) RPTOR [cytosol] (R-HSA-3006727) RPTOR [nucleoplasm] (R-HSA-5083664)	0.695	4
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.681	16
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.68	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.643	6
UniProt:Q13233 MAP3K1	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.609	2
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.596	7
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.596	6
UniProt:P17174 GOT1	1	PXLP-K259-GOT1 [cytosol] (R-HSA-1295497)	0.596	5
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.596	7
UniProt:O00255 MEN1	4	MEN1 [nucleoplasm] (R-HSA-2186626) MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [cytosol] (R-HSA-5672315)	0.596	4
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.596	4
UniProt:Q07864 POLE	1	POLE [nucleoplasm] (R-HSA-68473)	0.596	6
UniProt:Q13164 MAPK7	4	p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) MAPK7 [cytosol] (R-HSA-198754) MAPK7 [nucleoplasm] (R-HSA-199961)	0.596	5
UniProt:Q9BRP1 PDD2L			0.596	6
UniProt:P27987 ITPKB	1	ITPKB [cytosol] (R-HSA-1604605)	0.596	4
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.596	5
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.596	5
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.596	5
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.589	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.577	4
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.553	4
UniProt:Q9GZV4 EIF5A2	3	Hyp-K50-EIF5A2 [cytosol] (R-HSA-204650) EIF5A2 [cytosol] (R-HSA-204612) Dhp-K50-EIF5A2 [cytosol] (R-HSA-3149584)	0.553	4
UniProt:Q12967 RALGDS	1	RALGDS [cytosol] (R-HSA-171001)	0.553	4
UniProt:P21399 ACO1	1	ACO1 [cytosol] (R-HSA-5690899)	0.553	4
UniProt:P57735 RAB25	2	GGC-RAB25 [cytosol] (R-HSA-8873780) RAB25 [cytosol] (R-HSA-8873683)	0.553	4
UniProt:P48736 PIK3CG	1	PIK3CG [cytosol] (R-HSA-392286)	0.553	4
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.553	4
UniProt:P18074 ERCC2	2	ERCC2 [nucleoplasm] (R-HSA-67443) ERCC2 [cytosol] (R-HSA-2564770)	0.553	3
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.553	4
UniProt:P25311 AZGP1	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.553	3
UniProt:Q92843 B2CL2			0.553	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.553	4
UniProt:Q7Z589 EMSY			0.553	4
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.553	4
UniProt:P40259 CD79B	2	CD79B [plasma membrane] (R-HSA-197156) p-Y196,Y207-CD79B [plasma membrane] (R-HSA-983634)	0.553	3
UniProt:O75874 IDH1	10	IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132H mutant [cytosol] (R-HSA-880015)	0.553	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.553	4
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.553	3
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.553	4
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.553	4
UniProt:Q8IYM1 SEP12			0.553	4
UniProt:P28715 ERCC5	1	ERCC5 [nucleoplasm] (R-HSA-67447)	0.553	3
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.553	4
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.553	4
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.553	4
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.553	4
UniProt:P61224 RAP1B	2	RAP1B [plasma membrane] (R-HSA-377590) RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.553	4
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.553	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.553	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.544	4
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.539	3
UniProt:P07098 LIPF	1	LIPF [extracellular region] (R-HSA-6789323)	0.527	2
UniProt:Q15042 RAB3GAP1	2	RAB3GAP1 [endoplasmic reticulum membrane] (R-HSA-508581) RAB3GAP1 [cytosol] (R-HSA-8877982)	0.527	2
UniProt:Q9UH62 ARMCX3	1	ARMCX3 [mitochondrial outer membrane] (R-HSA-9714514)	0.527	2
UniProt:Q14154 DELE1	3	DELE1 [mitochondrial inner membrane] (R-HSA-9840377) DELE1(143-515) [cytosol] (R-HSA-9840380) DELE1(143-515) [mitochondrial inner membrane] (R-HSA-9840386)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	3
UniProt:Q9UIM3 FKBPL	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.527	2
UniProt:Q99N57	11	phospho-Raf1 [cytosol] (R-MMU-5672664) phospho-Raf1 [plasma membrane] (R-MMU-5672665) phospho-Raf1 [cytosol] (R-MMU-206028) phospho-Raf1 [cytosol] (R-MMU-9732747) Raf1 [cytosol] (R-MMU-167205) phospho-Raf1 [cytosol] (R-MMU-109786) phospho-Raf1 [plasma membrane] (R-MMU-5675420) phospho-Raf1 [plasma membrane] (R-MMU-206222) phospho-Raf1 [plasma membrane] (R-MMU-5675193) phospho-Raf1 [cytosol] (R-MMU-5624469) phospho-Raf1 [cytosol] (R-MMU-5624465)	0.499	3
UniProt:Q61097	5	phospho-Ksr1 [cytosol] (R-MMU-5672654) Ksr1 [cytosol] (R-MMU-5672587) phospho-Ksr1 [cytosol] (R-MMU-5672652) phospho-Ksr1 [plasma membrane] (R-MMU-5672659) phospho-Ksr1 [cytosol] (R-MMU-5672656)	0.499	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [secretory granule lumen] (R-HSA-6801515)	0.483	3
UniProt:Q16651 PRSS8	2	PRSS8(33-44) [plasma membrane] (R-HSA-8849805) PRSS8(45-322) [plasma membrane] (R-HSA-8849789)	0.471	2
UniProt:Q6W2J9 BCOR			0.471	2
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.471	2
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.471	2
UniProt:P30279 CCND2	2	CCND2 [cytosol] (R-HSA-68340) CCND2 [nucleoplasm] (R-HSA-113827)	0.471	2
UniProt:P52333 JAK3	6	JAK3 [cytosol] (R-HSA-451893) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [endosome] (R-HSA-8983184) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-Y980 JAK3 [cytosol] (R-HSA-9701438)	0.471	2
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.471	2
UniProt:Q03181 PPARD	1	PPARD [nucleoplasm] (R-HSA-446176)	0.471	2
UniProt:P19367 HK1	4	HK1 [cytosol] (R-HSA-70395) HK1 L529S [cytosol] (R-HSA-5621861) HK1 H577_C672del [cytosol] (R-HSA-5621873) HK1 T680S [cytosol] (R-HSA-5621880)	0.471	2
UniProt:Q92800 EZH1			0.471	2
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.471	2
UniProt:P08476 INHBA	1	INHBA [extracellular region] (R-HSA-205926)	0.471	2
UniProt:Q00597 FANCC	2	FANCC [nucleoplasm] (R-HSA-419530) FANCC [cytosol] (R-HSA-420801)	0.471	2
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807) p-Y551-BTK [plasma membrane] (R-HSA-9606165) BTK [cytosol] (R-HSA-197948) p-Y551-BTK [cytosol] (R-HSA-2685603) p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323)	0.471	2
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.471	2
UniProt:Q969H4 CNKSR1	1	CNKSR1 [cytosol] (R-HSA-5672629)	0.471	2
UniProt:Q15382 RHEB	2	RHEB [endosome membrane] (R-HSA-5656350) RHEB [lysosomal membrane] (R-HSA-165190)	0.471	2
UniProt:Q14209 E2F2	1	E2F2 [nucleoplasm] (R-HSA-68649)	0.471	2
UniProt:Q92747 ARPC1A	1	ARPC1A [cytosol] (R-HSA-200807)	0.471	2
UniProt:P08236 GUSB	9	GUSB [lysosomal lumen] (R-HSA-1678846) GUSB [ficolin-1-rich granule lumen] (R-HSA-6800967) GUSB [extracellular region] (R-HSA-6806207) GUSB [azurophil granule lumen] (R-HSA-6799122) GUSB S52F [lysosomal lumen] (R-HSA-2318391) GUSB R356* [lysosomal lumen] (R-HSA-2318372) GUSB A354V [lysosomal lumen] (R-HSA-2318376) GUSB R216W [lysosomal lumen] (R-HSA-2318584) GUSB R611W [lysosomal lumen] (R-HSA-2318382)	0.471	2
UniProt:Q96HB5 CC120			0.471	2
UniProt:A1E959 ODAM	1	ODAM [extracellular region] (R-HSA-977149)	0.471	2
UniProt:P30260 CDC27	2	CDC27 [cytosol] (R-HSA-174073) CDC27 [nucleoplasm] (R-HSA-174175)	0.471	2
UniProt:P53779 MAPK10	3	p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) MAPK10 [cytosol] (R-HSA-450352)	0.471	2
UniProt:P53778 MAPK12	3	MAPK12 [cytosol] (R-HSA-171025) p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833)	0.471	2
UniProt:Q96AV8 E2F7	1	E2F7 [nucleoplasm] (R-HSA-6798305)	0.471	2
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570)	0.471	2
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.471	2
UniProt:Q16633 OBF1			0.471	2
UniProt:Q9NRM7 LATS2	2	p-S872,T1041-LATS2 [cytosol] (R-HSA-2028565) LATS2 [cytosol] (R-HSA-2028580)	0.471	2
UniProt:Q9Y6E7 SIRT4	1	SIRT4 [mitochondrial matrix] (R-HSA-5687775)	0.471	2
UniProt:O95389 CCN6			0.471	2
UniProt:Q9HB63 NTN4	1	NTN4 [plasma membrane] (R-HSA-561258)	0.471	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.471	2
UniProt:Q9UIV8 SERPINB13	1	SERPINB13 [lysosomal lumen] (R-HSA-8938045)	0.471	2
UniProt:P21912 SDHB	2	SDHB [mitochondrial matrix] (R-HSA-9854983) SDHB [mitochondrial inner membrane] (R-HSA-70985)	0.471	2
UniProt:P36222 CHI3L1	2	CHI3L1 [extracellular region] (R-HSA-6806319) CHI3L1 [specific granule lumen] (R-HSA-6799507)	0.471	2
UniProt:P29992 GNA11	1	GNA11 [plasma membrane] (R-HSA-167446)	0.471	2
UniProt:P21860 ERBB3			0.471	2
UniProt:Q70Z35 PREX2	1	PREX2 [cytosol] (R-HSA-8850949)	0.471	2
UniProt:P30291 WEE1	4	WEE1 [nucleoplasm] (R-HSA-69253) p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) p-T187,T190-WEE1 [nucleoplasm] (R-HSA-9929669)	0.471	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.471	2
UniProt:O95754 SEMA4F	1	SEMA4F [plasma membrane] (R-HSA-3006460)	0.471	2
UniProt:Q86WJ1 CHD1L	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.471	2
UniProt:P78333 GPC5	20	HS(4)-GPC5 [plasma membrane] (R-HSA-2076696) HS(6)-GPC5 [plasma membrane] (R-HSA-2076676) HS(2)-GPC5 [plasma membrane] (R-HSA-2076649) HS(1)-GPC5 [plasma membrane] (R-HSA-2076689) HS(3)-GPC5 [plasma membrane] (R-HSA-2076628) HS(5)-GPC5 [plasma membrane] (R-HSA-2076646) GPC5(25-?) [Golgi lumen] (R-HSA-2054103) XylS-GPC5(25-?) [Golgi lumen] (R-HSA-2064160) Gal-Xyl-GPC5 [Golgi lumen] (R-HSA-2064133) Gal-Gal-Xyl-GPC5 [Golgi lumen] (R-HSA-2064053) GlcA-Gal-Gal-Xyl-GPC5 [Golgi lumen] (R-HSA-2064087) Heparan-GPC5 [Golgi lumen] (R-HSA-2076472) Heparan(1)-GPC5 [Golgi lumen] (R-HSA-2076584) Heparan(2)-GPC5 [Golgi lumen] (R-HSA-2076482) Heparan(3)-GPC5 [Golgi lumen] (R-HSA-2076376) Heparan(4)-GPC5 [Golgi lumen] (R-HSA-2076556) HS(1)-GPC5 [Golgi lumen] (R-HSA-2076486) HS(2)-GPC5 [Golgi lumen] (R-HSA-2076459) HS(3)-GPC5 [Golgi lumen] (R-HSA-2076544) HS(5)-GPC5 [Golgi lumen] (R-HSA-2076457)	0.471	2
UniProt:Q6ZNE5 ATG14	3	ATG14 [phagophore assembly site membrane] (R-HSA-5682389) ATG14 [endoplasmic reticulum membrane] (R-HSA-5679263) ATG14 [cytosol] (R-HSA-5668893)	0.471	2
UniProt:Q9NW38 FANCL	2	FANCL [nucleoplasm] (R-HSA-419520) FANCL [cytosol] (R-HSA-420789)	0.471	2
UniProt:P31040 SDHA	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.471	2
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.471	2
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.471	2

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