p-F595L BRAF [plasma membrane]

Stable Identifier
R-HSA-8936641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
B-RAF
Icon
p-F595L BRAF [plasma membrane] icon
p-F595L BRAF [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
15035987 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Wan, PT, Garnett, MJ, Roe, SM, Lee, S, Niculescu-Duvaz, D, Good, VM, Jones, CM, Marshall, CJ, Springer, CJ, Barford, D, Marais, R

Cell 2004
12068308 Mutations of the BRAF gene in human cancer

Davies, H, Bignell, GR, Cox, C, Stephens, P, Edkins, S, Clegg, S, Teague, J, Woffendin, H, Garnett, MJ, Bottomley, W, Davis, N, Dicks, E, Ewing, R, Floyd, Y, Gray, K, Hall, S, Hawes, R, Hughes, J, Kosmidou, V, Menzies, A, Mould, C, Parker, A, Stevens, C, Watt, S, Hooper, S, Wilson, R, Jayatilake, H, Gusterson, BA, Cooper, C, Shipley, J, Hargrave, D, Pritchard-Jones, K, Maitland, N, Chenevix-Trench, G, Riggins, GJ, Bigner, DD, Palmieri, G, Cossu, A, Flanagan, A, Nicholson, A, Ho, JW, Leung, SY, Yuen, ST, Weber, BL, Seigler, HF, Darrow, TL, Paterson, H, Marais, R, Marshall, CJ, Wooster, R, Stratton, MR, Futreal, PA

Nature 2002
External Reference Information
External Reference
UniProt:P15056 BRAF
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Genes
BioGPS Gene:673 BRAF
COSMIC (genes):BRAF BRAF
CTD Gene:673 BRAF
dbSNP Gene:673 BRAF
ENSEMBL:ENSG00000157764 BRAF
ENSEMBL_homo_sapiens_GENE:ENSG00000157764 BRAF
HGNC:1097 BRAF
KEGG Gene (Homo sapiens):673 BRAF
Monarch:673 BRAF
NCBI Gene:673 BRAF
OMIM:164757 BRAF
UCSC:P15056 BRAF
Reference Transcript
Other Identifiers
11732491_s_at
1654_at
17063631
1UWH
1UWJ
206044_s_at
2FB8
2L05
3076365
3076366
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3076441
3982166
3982173
3C4C
3D4Q
3IDP
3II5
3NY5
3OG7
3PPJ
3PPK
3PRF
3PRI
3PSB
3PSD
3Q4C
3Q96
3SKC
3TV4
3TV6
40306_at
4CQE
4DBN
4E26
4E4X
4EHE
4EHG
4FC0
4FK3
4G9C
4G9R
4H58
4JVG
4KSP
4KSQ
4MBJ
4MNE
4MNF
4PP7
4R5Y
4RZV
4RZW
4WO5
4XV1
4XV2
4XV3
4XV9
4YHT
5C9C
5CSW
5CSX
5CT7
5FD2
5HI2
5HID
5HIE
5ITA
5J17
5J18
5J2R
5JRQ
5JSM
5JT2
5VAL
5VAM
5VR3
5VYK
673
6B8U
6CAD
8143417
86199_r_at
A0A2R8Y467
A0A2R8Y679
A0A2R8Y8E0
A0A2R8YDP5
A0A2R8YES9
A0A2U3TZI2
A_23_P42935
AAA35609
AAA96495
AAD15551
AAD43193
AAI01758
AAI12080
AC006344
AC006347
ACD11489
AM989472
AM989473
AM989474
AM989475
AM989476
AM989477
BC101757
BC112079
BRAF
BRAF-220
CAA46301
CAB004552
CAQ43111
CAQ43112
CAQ43113
CAQ43114
CAQ43115
CAQ43116
CCDS5863
CH236950
EAL24023
ENSG00000157764
ENSP00000493543
ENST00000646891
EntrezGene:673
EU600171
g4757867_3p_a_at
GE58163
GE766137
GO:0000165
GO:0000166
GO:0000186
GO:0000902
GO:0002318
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007010
GO:0007155
GO:0007165
GO:0007267
GO:0008150
GO:0008219
GO:0008283
GO:0008542
GO:0009887
GO:0010628
GO:0010764
GO:0010828
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0022607
GO:0030154
GO:0030878
GO:0031434
GO:0033138
GO:0035019
GO:0035556
GO:0035690
GO:0040011
GO:0042127
GO:0042802
GO:0043005
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0043367
GO:0043368
GO:0043369
GO:0043434
GO:0043524
GO:0044297
GO:0045580
GO:0046632
GO:0046872
GO:0046982
GO:0048538
GO:0048679
GO:0048680
GO:0048856
GO:0048870
GO:0050772
GO:0050852
GO:0050877
GO:0051291
GO:0051496
GO:0051591
GO:0055085
GO:0060291
GO:0060323
GO:0060324
GO:0065003
GO:0070374
GO:0070413
GO:0071277
GO:0090150
GO:1900026
GO:1990090
GO:2000301
GO:2000352
H7C560
H7C5K3
HGNC:1097
HPA001328
HPA071048
ILMN_1652472
IPR000719
IPR001245
IPR002219
IPR003116
IPR008271
IPR011009
IPR017441
IPR020454
IPR029071
LRG_299
M21001
M95712
M95712_at
MIM:115150
MIM:163950
MIM:164757
MIM:211980
MIM:613706
MIM:613707
NM_004333
NP_004324
PF00130
PF02196
PF07714
PH_hs_0027912
PR00008
SM00109
SM00220
SM00455
TC07001927.hg
uc003vwc.5
UPI000013DF26
X65187
Participant Of
hasMember
Other forms of this molecule
BRAF-MACF1fusion [cytosol]
p-BRAF-MACF1 fusion [cytosol]
D594N BRAF [cytosol]
G596R BRAF [cytosol]
D594V BRAF [cytosol]
G466E BRAF [cytosol]
D594G BRAF [cytosol]
F595L BRAF [cytosol]
L597V BRAF [cytosol]
G464E BRAF [cytosol]
E586K BRAF [cytosol]
V600K BRAF [cytosol]
p-L597V BRAF [plasma membrane]
p-G464E BRAF [plasma membrane]
p-E586K BRAF [plasma membrane]
p-V600K BRAF [plasma membrane]
BRAF 599dupT [cytosol]
G469A BRAF [cytosol]
V600E BRAF [cytosol]
V600E BRAF V169_M438del [cytosol]
V600E BRAF V47_D380del [cytosol]
V600E BRAF V47_M438del [cytosol]
V600E BRAF V169_D380del [cytosol]
p-S445,S729-BRAF [plasma membrane]
p-S,T-BRAF [cytosol]
p-S365,S445,S729 BRAF [cytosol]
hyperphosphorylated BRAF [plasma membrane]
BRAF [cytosol]
p-S445,T599,S602,S729 BRAF [plasma membrane]
p-S445,S729-BRAF [cytosol]
p-S445,T599,S602,S729 BRAF [cytosol]
Modified Residues
Name
L-phenylalanine 595 replaced with L-leucine
Coordinate
595
PsiMod
L-phenylalanine removal [MOD:01644]
A protein modification that effectively removes or replaces an L-phenylalanine.
L-leucine residue [MOD:00020]
A protein modification that effectively converts a source amino acid residue to an L-leucine.
Name
O-phospho-L-serine at 445
Coordinate
445
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
colorectal cancer 9256
bladder carcinoma 4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Metabolites
COSMIC
GeneCards
DOCK Blaster
BRENDA (Homo sapiens)
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q02750 MAP2K1  7 0.976 58
 UniProt:P04049 RAF1  10 0.957 55
 UniProt:P15056 BRAF  32 0.907 13
 UniProt:P63104 YWHAZ  2 0.822 6
 UniProt:P31946 YWHAB  1 0.763 5
 UniProt:P01112 HRAS  7 0.719 4
 UniProt:P61981 YWHAG  1 0.688 3
 UniProt:P27348 YWHAQ  1 0.688 3
 UniProt:P10398 ARAF  4 0.669 3
 UniProt:P36507 MAP2K2  5 0.669 6
 UniProt:Q13233 MAP3K1  2 0.609 2
 UniProt:P01111 NRAS  8 0.591 3
 UniProt:P08238 HSP90AB1  5 0.564 2
 UniProt:P46940 IQGAP1  3 0.544 4
 UniProt:Q61097  5 0.499 3
 UniProt:Q99N57  10 0.499 3