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Ub-KEAP1 [cytosol]
Stable Identifier
R-HSA-6782766
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KEAP1, Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
Ub-KEAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14145 KEAP1
Gene Names
KEAP1, INRF2, KIAA0132, KLHL19
Chain
chain:1-624
Reference Genes
BioGPS Gene:9817 KEAP1
COSMIC (genes):KEAP1 KEAP1
CTD Gene:9817 KEAP1
dbSNP Gene:9817 KEAP1
ENSEMBL:ENSG00000079999 KEAP1
HGNC:23177 KEAP1
KEGG Gene (Homo sapiens):9817 KEAP1
Monarch:9817 KEAP1
NCBI Gene:9817 KEAP1
OMIM:606016 KEAP1
UCSC:Q14145 KEAP1
Reference Transcript
RefSeq:XM_011528452.1 KEAP1
RefSeq:NM_203500.1 KEAP1
RefSeq:XM_005260173.1 KEAP1
RefSeq:XM_005260174.1 KEAP1
RefSeq:NM_012289.3 KEAP1
Other Identifiers
0001340520
0006840484
11716444_a_at
16868743
202417_at
35322_at
3850364
3850365
3850366
3850367
3850369
3850370
3850371
3850372
3850373
3850374
3850376
3850377
3850378
3850379
3850381
8034034
9817
A_23_P119141
D50922_at
GE57257
GO:0001701
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0006355
GO:0006464
GO:0006511
GO:0006914
GO:0006950
GO:0008134
GO:0008150
GO:0009056
GO:0009058
GO:0009790
GO:0010506
GO:0016032
GO:0016234
GO:0016567
GO:0016579
GO:0030154
GO:0030496
GO:0031463
GO:0032436
GO:0032991
GO:0034451
GO:0034599
GO:0034641
GO:0042802
GO:0042994
GO:0043226
GO:0043433
GO:0043687
GO:0044403
GO:0045604
GO:0048856
GO:0071353
GO:0097718
HMNXSV003035494
ILMN_1711787
ILMN_1775920
ILMN_2410771
ILMN_2410772
PH_hs_0003698
TC19001166.hg
g6912451_3p_at
Participates
as a member of
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
Other forms of this molecule
ub-KEAP1 [cytosol]
KEAP1 [cytosol]
Inferred To
Keap1 [cytosol]
(Mus musculus)
Keap1 [cytosol]
(Rattus norvegicus)
KEAP1 [cytosol]
(Canis familiaris)
KEAP1 [cytosol]
(Sus scrofa)
keap1b [cytosol]
(Danio rerio)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005260231.1
,
NP_987096.1
,
XP_005260230.1
,
NP_036421.2
,
XP_011526754.1
Guide to Pharmacology - Targets
2757
OpenTargets
ENSG00000079999
ZINC - Substances
KEAP1_HUMAN
ZINC target
Q14145
PRO
Q14145
GlyGen
Q14145
PDB
6Z6A
,
3ZGC
,
5GIT
,
5WHO
,
7K2I
,
4IN4
,
7K2J
,
6ROG
,
4L7D
,
4IFL
,
6LRZ
,
4L7C
,
4IFJ
,
4L7B
,
5WHL
,
3ZGD
,
6UF0
,
6HWS
,
6V6Z
,
6TYM
,
5X54
,
6SP4
,
4N1B
,
1U6D
,
3VNH
,
4IQK
,
5F72
,
6SP1
,
6FFM
,
6WCQ
,
5WFV
,
6FMQ
,
5WG1
,
6T7V
,
7K2H
,
1ZGK
,
4CXT
,
6T7Z
,
5WFL
,
3VNG
,
7K2Q
,
7K2D
,
7K2R
,
4XMB
,
7K2E
,
7K2F
,
6FMP
,
7K2G
,
7K2S
,
7K2N
,
7K2A
,
7K2B
,
6W67
,
6TYP
,
6W68
,
7K2C
,
7K2O
,
5NLB
,
4IFN
,
7K2P
,
5WIY
,
6W69
,
5DAF
,
7K28
,
7K2K
,
2FLU
,
7K29
,
4CXJ
,
5DAD
,
7K2L
,
7K2M
,
6TG8
,
6W66
,
4CXI
HPA
ENSG00000079999-KEAP1
GeneCards
Q14145
Ensembl
ENSP00000171111
,
ENSP00000377245
,
ENSG00000079999
,
ENST00000171111
,
ENST00000393623
Pharos - Targets
Q14145
ZINC - Predictions - Purchasable
KEAP1_HUMAN
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16236 NFE2L2
12
p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.972
34
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.963
19
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.834
8
UniProt:P62495 ETF1
2
Me-Q185-ETF1 [cytosol]
(R-HSA-6800157)
ETF1 [cytosol]
(R-HSA-54433)
0.834
8
UniProt:Q86YC2 PALB2
20
PALB2 Y28C [nucleoplasm]
(R-HSA-9724169)
PALB2 L35P [nucleoplasm]
(R-HSA-9724168)
PALB2 L24S [nucleoplasm]
(R-HSA-9724172)
PALB2 L21A [nucleoplasm]
(R-HSA-9704339)
PALB2 R37H [nucleoplasm]
(R-HSA-9724178)
PALB2 L21F [nucleoplasm]
(R-HSA-9704347)
PALB2 E12* [nucleoplasm]
(R-HSA-9704349)
PALB2 R37C [nucleoplasm]
(R-HSA-9724188)
PALB2 L35F [nucleoplasm]
(R-HSA-9704338)
PALB2 L947F [nucleoplasm]
(R-HSA-9724554)
PALB2 G1043D [nucleoplasm]
(R-HSA-9724584)
PALB2 T1030I [nucleoplasm]
(R-HSA-9704424)
PALB2 T841Qfs*10 [nucleoplasm]
(R-HSA-9704749)
PALB2 L1119P [nucleoplasm]
(R-HSA-9724589)
PALB2 L947S [nucleoplasm]
(R-HSA-9724557)
PALB2 L1143P [nucleoplasm]
(R-HSA-9704428)
PALB2 L1070P [nucleoplasm]
(R-HSA-9724556)
PALB2 C77Vfs100* [nucleoplasm]
(R-HSA-9704738)
PALB2 L939W [nucleoplasm]
(R-HSA-9704417)
PALB2 L961P [nucleoplasm]
(R-HSA-9724583)
0.666
4
UniProt:Q13153 PAK1
6
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144-PAK1 [cytosol]
(R-HSA-451339)
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.611
3
UniProt:Q9Y2D1 ATF5
1
ATF5 [nucleoplasm]
(R-HSA-9653719)
0.611
3
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB [cytosol]
(R-HSA-168114)
0.61
6
UniProt:Q04206 RELA
6
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.592
4
UniProt:Q9H1Y0 ATG5
3
ATG5 [phagocytic vesicle membrane]
(R-HSA-5205636)
GlyK130-ATG5 [cytosol]
(R-HSA-5683582)
ATG5 [cytosol]
(R-HSA-936010)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9P0N9 TBC1D7
1
TBC1D7 [cytosol]
(R-HSA-8854154)
0.556
3
UniProt:Q9NX09 DDIT4
1
DDIT4 [cytosol]
(R-HSA-5632374)
0.556
3
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.556
3
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.556
3
UniProt:Q9UGK3 STAP2
2
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
STAP2 [cytosol]
(R-HSA-8848028)
0.556
3
UniProt:Q15149 PLEC
3
PLEC(2396-4684) [cytosol]
(R-HSA-350618)
PLEC(1-2395) [cytosol]
(R-HSA-350638)
PLEC [cytosol]
(R-HSA-201575)
0.544
3
UniProt:O95997 PTTG1
2
K11polyUb-PTTG1 [cytosol]
(R-HSA-3095943)
PTTG1 [cytosol]
(R-HSA-174190)
0.544
2
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.527
2
UniProt:O88351
2
phospho-Ikbkb [cytosol]
(R-MMU-202506)
Ikbkb [cytosol]
(R-MMU-168114)
0.508
2
UniProt:Q5JTC6 AMER1
5
AMER1 R497* [cytosol]
(R-HSA-9663943)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 [cytosol]
(R-HSA-1504189)
0.499
2
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