Reactome | Ub-KEAP1 [cytosol]

Ub-KEAP1 [cytosol]

Stable Identifier

R-HSA-6782766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

KEAP1, Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
        
        Ub-KEAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14145 KEAP1

Gene Names

KEAP1, INRF2, KIAA0132, KLHL19

Chain

chain:1-624

Reference Genes

BioGPS Gene:9817 KEAP1

COSMIC (genes):KEAP1 KEAP1

CTD Gene:9817 KEAP1

dbSNP Gene:9817 KEAP1

ENSEMBL:ENSG00000079999 KEAP1

ENSEMBL:ENSG00000079999.14 KEAP1

HGNC:23177 KEAP1

KEGG Gene (Homo sapiens):9817 KEAP1

Monarch:9817 KEAP1

NCBI Gene:9817 KEAP1

OMIM:606016 KEAP1

UCSC:Q14145 KEAP1

Reference Transcript

Other Identifiers

11716444_a_at

16868743

202417_PM_at

202417_at

35322_at

3850364

3850365

3850366

3850367

3850369

3850370

3850371

3850372

3850373

3850374

3850376

3850377

3850378

3850379

3850381

8034034

9817

A_23_P119141

D50922_at

GE57257

GO:0001701

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0006351

GO:0006355

GO:0006511

GO:0006914

GO:0008152

GO:0010506

GO:0016234

GO:0016567

GO:0030154

GO:0030163

GO:0030496

GO:0031463

GO:0032436

GO:0032991

GO:0034451

GO:0034599

GO:0036211

GO:0042802

GO:0042994

GO:0043226

GO:0043433

GO:0045604

GO:0048856

GO:0060090

GO:0061629

GO:0070887

GO:0071353

GO:0097718

GO:0098772

GO:0140416

GO:1990756

HMNXSV003035494

ILMN_1711787

ILMN_2410771

ILMN_2410772

PH_hs_0003698

TC19001166.hg

g6912451_3p_at

Participates

as a member of

Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)

Other forms of this molecule

ub-KEAP1 [cytosol]

KEAP1 [cytosol]

Inferred To

Ub-KEAP1 [cytosol] (Canis familiaris)

keap1 [cytosol] (Xenopus tropicalis)

Keap1 [cytosol] (Drosophila melanogaster)

Keap1 [cytosol] (Mus musculus)

Keap1 [cytosol] (Rattus norvegicus)

KEAP1 [cytosol] (Bos taurus)

KEAP1 [cytosol] (Sus scrofa)

keap1b [cytosol] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position

Modification

polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_011526754.1, NP_036421.2, NP_987096.1, XP_005260230.1, XP_005260231.1

Guide to Pharmacology - Targets

2757

OpenTargets

ENSG00000079999

ZINC - Substances

KEAP1_HUMAN

HPA

ENSG00000079999-KEAP1

GeneCards

Q14145

ZINC target

Q14145

Ensembl

ENSG00000079999, ENST00000171111, ENSP00000171111, ENST00000393623, ENSP00000377245

PRO

Q14145

Pharos - Targets

Q14145

ZINC - Predictions - Purchasable

KEAP1_HUMAN

PDB

7Q6Q, 4N1B, 7K2R, 6W69, 7K2Q, 7K2C, 6HWS, 4L7C, 6W67, 7K2O, 4XMB, 3VNH, 6WCQ, 7K2N, 6W66, 5WG1, 5WFV, 4IFN, 7K2M, 7K2L, 4L7B, 6SP1, 5X54, 7Q5H, 3ZGD, 6FFM, 7XM5, 1ZGK, 3ZGC, 7XM4, 6T7Z, 5F72, 6Z6A, 6V6Z, 7Q6S, 7XM3, 5NLB, 2FLU, 7EXI, 7K2F, 6UF0, 6T7V, 4CXJ, 7K2S, 7K2E, 7K2D, 4CXI, 6W68, 7K2B, 6FMQ, 6LRZ, 7K2A, 7K2P, 1U6D, 5WHO, 6FMP, 6TYP, 4L7D, 4IFL, 7K29, 7X4X, 5GIT, 5WHL, 6TYM, 7X4W, 6TG8, 5WIY, 7K28, 3VNG, 5WFL, 6SP4, 4IFJ, 7K2K, 5DAF, 7K2J, 5DAD, 4IN4, 7Q96, 7K2I, 7K2H, 4CXT, 7K2G, 4IQK, 7Q8R, 6ROG, 7XM2

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.972	34
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.959	18
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.834	8
UniProt:P62495 ETF1	3	Me-Q185-ETF1 [cytosol] (R-HSA-6800157) 4OHK63-ETF1 [cytosol] (R-HSA-9629948) ETF1 [cytosol] (R-HSA-54433)	0.834	8
UniProt:Q9NY33 DPP3	1	DPP3 [cytosol] (R-HSA-9795741)	0.834	8
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.781	7
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.742	5
UniProt:Q96TA1 NIBA2			0.726	9
UniProt:Q6P9E2 Q6P9E2			0.718	6
UniProt:P06454-2 PTMA			0.718	6
UniProt:Q6P1L5 F117B			0.718	6
UniProt:P54619 PRKAG1	2	PRKAG1 [nucleoplasm] (R-HSA-2151202) PRKAG1 [cytosol] (R-HSA-380946)	0.718	6
UniProt:P62310 LSM3	2	LSM3 [nucleoplasm] (R-HSA-6806807) LSM3 [cytosol] (R-HSA-429894)	0.718	6
UniProt:Q14494 NF2L1			0.704	28
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.666	5
UniProt:P02724 GYPA	1	GYPA [plasma membrane] (R-HSA-8867204)	0.666	4
UniProt:Q9NPC3 CIP1			0.666	4
UniProt:O14525-2 ASTN1			0.618	4
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.61	6
UniProt:Q9Y3Q8 T22D4			0.608	3
UniProt:P45381 ASPA	1	ASPA [cytosol] (R-HSA-5691513)	0.601	4
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.592	4
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.59	5
UniProt:Q9BTE3 MCMBP			0.564	2
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:B8Q183 B8Q183			0.556	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.556	3
UniProt:P02458-1 COL2A1			0.556	3
UniProt:Q2NKX9 CB068			0.556	3
UniProt:P05107 ITGB2	4	ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [tertiary granule membrane] (R-HSA-6803342) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [plasma membrane] (R-HSA-198010)	0.556	3
UniProt:A9UGY9 A9UGY9			0.556	3
UniProt:Q14440 Q14440			0.556	3
UniProt:P05362 ICAM1	1	ICAM1 [plasma membrane] (R-HSA-197683)	0.556	3
UniProt:P58317 ZN121			0.556	3
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.556	3
UniProt:Q6P6B1 ERIC5			0.556	3
UniProt:Q9P202 WHRN	1	WHRN [cytosol] (R-HSA-204726)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O60336 MABP1			0.556	3
UniProt:Q9NX65 ZSCAN32	1	ZSCAN32 [nucleoplasm] (R-HSA-1247547)	0.556	3
UniProt:A0A0C4DFT7 A0A0C4DFT7			0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:Q8TDV0 GP151			0.556	3
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.556	3
UniProt:Q8N573-5 OXR1			0.556	3
UniProt:Q9NZJ9 NUDT4	1	NUDT4 [cytosol] (R-HSA-1604676)	0.556	3
UniProt:Q9BTE3-2 MCMBP			0.556	3
UniProt:Q9UH77 KLHL3	1	KLHL3 [cytosol] (R-HSA-8863198)	0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:P17709	7	HK3 [secretory granule lumen] (R-SCE-6801511-3) HK3 [extracellular region] (R-SCE-6806457-3) HK3 [ficolin-1-rich granule lumen] (R-SCE-6801527-3) GCK [nucleoplasm] (R-SCE-450102-3) HK3 [cytosol] (R-SCE-70412-3) GCK [cytosol] (R-SCE-450094-3) HK1 [cytosol] (R-SCE-70395-3)	0.556	3
UniProt:O95198 KLHL2	1	KLHL2 [cytosol] (R-HSA-8863217)	0.556	3
UniProt:P38109 ATG42			0.556	3
UniProt:Q4KMZ1 IQCC			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q8N4I8 Q8N4I8			0.556	3
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.556	3
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.556	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.556	3
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.556	3
UniProt:Q15149 PLEC	3	PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575)	0.544	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.527	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:O88351	2	phospho-p-S177,S181-IKBKB [cytosol] (R-MMU-202506) IKBKB [cytosol] (R-MMU-168114)	0.508	2
UniProt:P15314	1	Irf1 [nucleoplasm] (R-MMU-983456)	0.499	2
UniProt:P58004 SESN2	1	SESN2 [cytosol] (R-HSA-5629143)	0.499	3
UniProt:Q5JTC6 AMER1	5	AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.499	2

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