Reactome | Ub-KEAP1 [cytosol]

Ub-KEAP1 [cytosol]

Stable Identifier

R-HSA-6782766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

KEAP1, Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-KEAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14145 KEAP1

Gene Names

KEAP1, INRF2, KIAA0132, KLHL19

Chain

chain:1-624

Reference Genes

BioGPS Gene:9817 KEAP1

COSMIC (genes):KEAP1 KEAP1

CTD Gene:9817 KEAP1

dbSNP Gene:9817 KEAP1

ENSEMBL:ENSG00000079999 KEAP1

HGNC:23177 KEAP1

KEGG Gene (Homo sapiens):9817 KEAP1

Monarch:9817 KEAP1

NCBI Gene:9817 KEAP1

OMIM:606016 KEAP1

UCSC:Q14145 KEAP1

Reference Transcript

Other Identifiers

0001340520

0006840484

11716444_a_at

16868743

202417_at

35322_at

3850364

3850365

3850366

3850367

3850369

3850370

3850371

3850372

3850373

3850374

3850376

3850377

3850378

3850379

3850381

8034034

9817

A_23_P119141

D50922_at

GE57257

GO:0001701

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0006355

GO:0006464

GO:0006511

GO:0006914

GO:0006950

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0009790

GO:0010506

GO:0016032

GO:0016234

GO:0016567

GO:0016579

GO:0030154

GO:0030496

GO:0031463

GO:0032436

GO:0032991

GO:0034451

GO:0034599

GO:0034641

GO:0042802

GO:0042994

GO:0043226

GO:0043433

GO:0043687

GO:0044403

GO:0045604

GO:0048856

GO:0071353

GO:0097718

HMNXSV003035494

ILMN_1711787

ILMN_1775920

ILMN_2410771

ILMN_2410772

PH_hs_0003698

TC19001166.hg

g6912451_3p_at

Participates

as a member of

Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)

Other forms of this molecule

KEAP1 [cytosol]

Inferred To

Keap1 [cytosol] (Mus musculus)

Keap1 [cytosol] (Rattus norvegicus)

KEAP1 [cytosol] (Canis familiaris)

KEAP1 [cytosol] (Sus scrofa)

keap1b [cytosol] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_011526754.1, XP_005260231.1, NP_987096.1, XP_005260230.1, NP_036421.2

OpenTargets

ENSG00000079999

HPA

ENSG00000079999-KEAP1

ZINC - Substances

KEAP1_HUMAN

GeneCards

Q14145

ZINC target

Q14145

Ensembl

ENST00000171111, ENSP00000377245, ENSG00000079999, ENSP00000171111, ENST00000393623

PRO

Q14145

ZINC - Predictions - Purchasable

KEAP1_HUMAN

PDB

5DAF, 6TYP, 6W66, 6W67, 5WFL, 6ROG, 4XMB, 6W68, 5WIY, 6W69, 4N1B, 5WG1, 5WFV, 6TG8, 4IQK, 4CXJ, 4IN4, 6FMP, 4CXI, 4IFJ, 6FMQ, 5F72, 4IFL, 4L7B, 6WCQ, 6T7V, 4IFN, 6FFM, 4L7C, 3VNH, 1U6D, 4L7D, 3VNG, 5GIT, 5X54, 3ZGD, 6UF0, 6V6Z, 6T7Z, 3ZGC, 5WHL, 4CXT, 6SP1, 5NLB, 5WHO, 6SP4, 6LRZ, 1ZGK, 5DAD, 6TYM, 2FLU, 6HWS

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	5	p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.972	34
UniProt:Q13501 SQSTM1	2	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961)	0.96	18
UniProt:P62495 ETF1	2	ETF1 [cytosol] (R-HSA-54433) Me-Q185-ETF1 [cytosol] (R-HSA-6800157)	0.834	8
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.834	8
UniProt:Q86YC2 PALB2	1	PALB2 [nucleoplasm] (R-HSA-419548)	0.666	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.61	6
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.592	4
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [cytosol] (R-HSA-5205651)	0.564	2
UniProt:Q9H1Y0 ATG5	3	GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) ATG5 [cytosol] (R-HSA-936010)	0.556	3
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.556	3
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.556	3
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:P02452 COL1A1	129	3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441) Dehydrolysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396169) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396104) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396303) Dehydrolysinonorlysyl Collagen alpha-1(I) chain [extracellular region] (R-HSA-2396380) Dehydrolysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396242) Dehydrolysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396258) Dehydrolysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396112) Dehydrolysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396455) Dehydrolysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396214) Dehydrolysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396310) Hydroxylysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396396) Hydroxylysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396247) Hydroxylysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396452) Lysino-5-ketonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396297) Lysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396479) Lysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396336) 3x4Hyp-3Hyp-Alys-COL1A1 [extracellular region] (R-HSA-2228701) Alys-COL1A1 [extracellular region] (R-HSA-2228703) 3x4Hyp-Alys-COL1A1 [extracellular region] (R-HSA-2228686) Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228697) 3x4Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228712) 3x4Hyp-3Hyp-5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228696) 3x4Hyp-5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228709) 3x4Hyp-3Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228692) Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228695) 3x4Hyp-Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228710) 5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228706) 3x4Hyp-3Hyp-Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228690) Dehydrohydroxylysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396090) Dehydrohydroxylysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396138) Dehydrohydroxylysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396266) Dehydrohydroxylysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396072) Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396344) Dehydrohydroxylysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396066) Dehydrohydroxylysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396434) Dehydrohydroxylysinonorlysyl Collagen alpha-1(I) chain [extracellular region] (R-HSA-2396065) Dehydrohydroxylysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396369) Dehydrohydroxylysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396023) Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396215) Dehydrohydroxylysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396278) Hydroxylysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396043) Hydroxylysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396302) Hydroxylysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396050) Hydroxylysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396211) Hydroxylysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396305) Hydroxylysino-5-ketonorlysyl 5-hydroxylysyl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396196) Hydroxyallysyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396424) Hydroxyallysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396384) Hydroxyallysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396309) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268636) GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268623) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268639) GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268649) 3x4Hyp-GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268681) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268648) COL1A1(23-1464) [extracellular region] (R-HSA-2268635) 3x4Hyp-3Hyp-COL1A1(23-1464) [extracellular region] (R-HSA-2268634) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268656) 5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268624) 3x4Hyp-5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268643) 3x4Hyp-COL1A1(23-1464) [extracellular region] (R-HSA-2268642) 3x4Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268813) 3x4Hyp-GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268893) 3x4Hyp-3Hyp-GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268892) 3x4Hyp-5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268815) 5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268895) GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268807) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268743) 3x4Hyp-3Hyp-5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268935) GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268742) 3x4Hyp-COL1A1(162-1464) [extracellular region] (R-HSA-2268913) COL1A1(162-1464) [extracellular region] (R-HSA-2268848) 3x4Hyp-3Hyp-COL1A1(162-1464) [extracellular region] (R-HSA-2268739) 3x4Hyp-3Hyp-COL1A1(954-1218) [extracellular region] (R-HSA-2467162) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467131) GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467128) COL1A1(954-1218) [extracellular region] (R-HSA-2467160) 3x4Hyp-GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467129) 3x4Hyp-GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467134) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467167) 3x4Hyp-5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467165) 3x4Hyp-3Hyp-GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467154) 3x4Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467155) 3x4Hyp-5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467153) 3x4Hyp-3Hyp-5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467159) 3x4Hyp-3Hyp-GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467157) GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467178) 3x4Hyp-3Hyp-5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467179) 5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467144) 3x4Hyp-COL1A1(162-953) [extracellular region] (R-HSA-2467151) 3x4Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467180) GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467149) GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467168) COL1A1(162-953) [extracellular region] (R-HSA-2467136) 3x4Hyp-COL1A1(954-1218) [extracellular region] (R-HSA-2467137) 3x4Hyp-3Hyp-COL1A1(162-953) [extracellular region] (R-HSA-2467174) 5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467172) 3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089968) GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089969) 3x4Hyp-GalHyl-COL1A1 [extracellular region] (R-HSA-2089985) GalHyl-COL1A1 [extracellular region] (R-HSA-2089982) 3x4Hyp-3Hyp-GalHyl-COL1A1 [extracellular region] (R-HSA-2089980) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089979) COL1A1 [extracellular region] (R-HSA-51125) 3x4Hyp-5Hyl-COL1A1 [extracellular region] (R-HSA-2089992) 5Hyl-COL1A1 [extracellular region] (R-HSA-2089974) 3x4Hyp-3Hyp-COL1A1 [extracellular region] (R-HSA-2089989) 3x4Hyp-COL1A1 [extracellular region] (R-HSA-2089988) 3x4Hyp-3Hyp-5Hyl-COL1A1 [extracellular region] (R-HSA-2089986)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O88351	2	Ikbkb [cytosol] (R-MMU-168114) phospho-Ikbkb [cytosol] (R-MMU-202506)	0.508	2
UniProt:Q5JTC6 AMER1	5	AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.499	2

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