Reactome | Ub-KEAP1 [cytosol]

Ub-KEAP1 [cytosol]

Stable Identifier

R-HSA-6782766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

KEAP1, Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-KEAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14145 KEAP1

Gene Names

KEAP1, INRF2, KIAA0132, KLHL19

Chain

chain:1-624

Reference Genes

BioGPS Gene:9817 KEAP1

COSMIC (genes):KEAP1 KEAP1

CTD Gene:9817 KEAP1

dbSNP Gene:9817 KEAP1

ENSEMBL:ENSG00000079999 KEAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000079999 KEAP1

HGNC:23177 KEAP1

KEGG Gene (Homo sapiens):9817 KEAP1

Monarch:9817 KEAP1

NCBI Gene:9817 KEAP1

OMIM:606016 KEAP1

UCSC:Q14145 KEAP1

Reference Transcript

Other Identifiers

0001340520

0006840484

11716444_a_at

16868743

1U6D

1ZGK

202417_at

25337

2FLU

35322_at

3850365

3850366

3850367

3850369

3850370

3850371

3850372

3850373

3850374

3850376

3850381

3VNG

3VNH

3ZGC

3ZGD

4CXI

4CXJ

4CXT

4IFJ

4IFL

4IFN

4IN4

4IQK

4L7B

4L7C

4L7D

4N1B

4XMB

5558

5DAD

5DAF

5F72

5GIT

5NLB

5X54

8034034

9817

A0A024R7C0

A_23_P119141

AAH02417

AAH02930

AAH15945

AAH21957

AAK43722

AAK51082

BAA09481

BAG51647

CAB025337

CCDS12239

D50922_at

EAW84110

EAW84111

EAW84112

ENSG00000079999

ENSP00000171111

ENSP00000377245

ENST00000171111

ENST00000393623

EntrezGene:9817

g6912451_3p_at

GE57257

GO:0001701

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0006355

GO:0006464

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0009790

GO:0010499

GO:0016567

GO:0016579

GO:0030154

GO:0030496

GO:0031463

GO:0032436

GO:0032991

GO:0034641

GO:0042802

GO:0042803

GO:0042994

GO:0043226

GO:0043433

GO:0043687

GO:0045604

GO:0048856

GO:0071353

GO:0097718

HGNC:23177

HPA005558

ILMN_1711787

ILMN_1775920

ILMN_2410771

ILMN_2410772

IPR000210

IPR006652

IPR011333

IPR011705

IPR015915

IPR017096

IPR030563

K7EJ49

K7EJD8

K7ESE0

KEAP1

KEAP1-201

KEAP1-202

MIM:606016

NM_012289

NM_203500

NP_036421

NP_987096

PF00651

PF01344

PF07707

PH_hs_0003698

SM00225

SM00612

SM00875

TC19001166.hg

uc002moq.2

uc002mor.2

UPI000007139C

XM_005260173

XM_005260174

XM_011528452

XP_005260230

XP_005260231

XP_011526754

Participant Of

hasMember

Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol]

Other forms of this molecule

KEAP1 [cytosol]

Inferred To

Ub-KEAP1 [cytosol] (Bos taurus)

Ub-KEAP1 [cytosol] (Canis familiaris)

Ub-KEAP1 [cytosol] (Danio rerio)

Ub-KEAP1 [cytosol] (Drosophila melanogaster)

Ub-KEAP1 [cytosol] (Gallus gallus)

Ub-KEAP1 [cytosol] (Mus musculus)

Ub-KEAP1 [cytosol] (Rattus norvegicus)

Ub-KEAP1 [cytosol] (Sus scrofa)

Ub-KEAP1 [cytosol] (Taeniopygia guttata)

Ub-KEAP1 [cytosol] (Xenopus tropicalis)

Homologues of Ub-KEAP1 [cytosol] (Drosophila melanogaster)

Homologues of Ub-KEAP1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_005260230.1, NP_036421.2, XP_005260231.1, NP_987096.1, XP_011526754.1

OpenTargets

ENSG00000079999

GeneCards

Q14145

ZINC - Substances

KEAP1_HUMAN

DOCK Blaster

3VNG, 4N1B, 3VNH, 1U6D, 5F72, 4L7C, 2FLU, 4L7D, 1ZGK, 3ZGC, 3ZGD, 5NLB, 4IFN, 5DAF, 4IN4, 5DAD, 4IQK, 4CXI, 4IFJ, 4IFL, 4CXT, 4CXJ, 5X54, 4L7B, 4XMB

ZINC target

Q14145

PRO

Q14145

ZINC - Predictions - Purchasable

KEAP1_HUMAN

PDB

3VNH, 5NLB, 3VNG, 4CXI, 4IQK, 4CXJ, 5DAD, 4IN4, 5F72, 5DAF, 4CXT, 3ZGC, 1ZGK, 5WFL, 5X54, 4L7B, 2FLU, 5WIY, 4L7C, 3ZGD, 5GIT, 4IFJ, 4XMB, 4L7D, 4IFL, 5WHL, 5WG1, 5WFV, 6FMP, 4IFN, 1U6D, 5WHO, 4N1B, 6FMQ

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	2	SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.952	16
UniProt:P62495 ETF1	2	ETF1 [cytosol] (R-HSA-54433) Me-Q185-ETF1 [cytosol] (R-HSA-6800157)	0.821	7
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.77	6
UniProt:Q86YC2 PALB2	1	PALB2 [nucleoplasm] (R-HSA-419548)	0.621	3
UniProt:O14920 IKBKB	3	p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB [cytosol] (R-HSA-168114) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.61	6
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.592	4
UniProt:Q5JTC6 AMER1	3	AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 [cytosol] (R-HSA-1504189)	0.499	2
UniProt:P02452 COL1A1	129	3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441) Dehydrolysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396169) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396104) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396303) Dehydrolysinonorlysyl Collagen alpha-1(I) chain [extracellular region] (R-HSA-2396380) Dehydrolysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396242) Dehydrolysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396258) Dehydrolysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396112) Dehydrolysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396455) Dehydrolysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396214) Dehydrolysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396310) Hydroxylysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396396) Hydroxylysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396247) Hydroxylysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396452) Lysino-5-ketonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396297) Lysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396479) Lysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396336) 3x4Hyp-3Hyp-Alys-COL1A1 [extracellular region] (R-HSA-2228701) Alys-COL1A1 [extracellular region] (R-HSA-2228703) 3x4Hyp-Alys-COL1A1 [extracellular region] (R-HSA-2228686) Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228697) 3x4Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228712) 3x4Hyp-3Hyp-5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228696) 3x4Hyp-5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228709) 3x4Hyp-3Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228692) Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228695) 3x4Hyp-Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228710) 5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228706) 3x4Hyp-3Hyp-Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228690) Dehydrohydroxylysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396090) Dehydrohydroxylysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396138) Dehydrohydroxylysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396266) Dehydrohydroxylysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396072) Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396344) Dehydrohydroxylysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396066) Dehydrohydroxylysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396434) Dehydrohydroxylysinonorlysyl Collagen alpha-1(I) chain [extracellular region] (R-HSA-2396065) Dehydrohydroxylysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396369) Dehydrohydroxylysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396023) Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396215) Dehydrohydroxylysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396278) Hydroxylysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396043) Hydroxylysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396302) Hydroxylysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396050) Hydroxylysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396211) Hydroxylysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396305) Hydroxylysino-5-ketonorlysyl 5-hydroxylysyl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396196) Hydroxyallysyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396424) Hydroxyallysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396384) Hydroxyallysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396309) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268636) GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268623) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268639) GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268649) 3x4Hyp-GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268681) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268648) COL1A1(23-1464) [extracellular region] (R-HSA-2268635) 3x4Hyp-3Hyp-COL1A1(23-1464) [extracellular region] (R-HSA-2268634) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268656) 5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268624) 3x4Hyp-5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268643) 3x4Hyp-COL1A1(23-1464) [extracellular region] (R-HSA-2268642) 3x4Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268813) 3x4Hyp-GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268893) 3x4Hyp-3Hyp-GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268892) 3x4Hyp-5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268815) 5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268895) GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268807) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268743) 3x4Hyp-3Hyp-5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268935) GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268742) 3x4Hyp-COL1A1(162-1464) [extracellular region] (R-HSA-2268913) COL1A1(162-1464) [extracellular region] (R-HSA-2268848) 3x4Hyp-3Hyp-COL1A1(162-1464) [extracellular region] (R-HSA-2268739) 3x4Hyp-3Hyp-COL1A1(954-1218) [extracellular region] (R-HSA-2467162) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467131) GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467128) COL1A1(954-1218) [extracellular region] (R-HSA-2467160) 3x4Hyp-GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467129) 3x4Hyp-GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467134) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467167) 3x4Hyp-5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467165) 3x4Hyp-3Hyp-GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467154) 3x4Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467155) 3x4Hyp-5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467153) 3x4Hyp-3Hyp-5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467159) 3x4Hyp-3Hyp-GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467157) GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467178) 3x4Hyp-3Hyp-5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467179) 5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467144) 3x4Hyp-COL1A1(162-953) [extracellular region] (R-HSA-2467151) 3x4Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467180) GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467149) GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467168) COL1A1(162-953) [extracellular region] (R-HSA-2467136) 3x4Hyp-COL1A1(954-1218) [extracellular region] (R-HSA-2467137) 3x4Hyp-3Hyp-COL1A1(162-953) [extracellular region] (R-HSA-2467174) 5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467172) 3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089968) GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089969) 3x4Hyp-GalHyl-COL1A1 [extracellular region] (R-HSA-2089985) 3x4Hyp-3Hyp-5Hyl-COL1A1 [extracellular region] (R-HSA-2089986) 3x4Hyp-COL1A1 [extracellular region] (R-HSA-2089988) GalHyl-COL1A1 [extracellular region] (R-HSA-2089982) 3x4Hyp-3Hyp-GalHyl-COL1A1 [extracellular region] (R-HSA-2089980) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089979) COL1A1 [extracellular region] (R-HSA-51125) 3x4Hyp-5Hyl-COL1A1 [extracellular region] (R-HSA-2089992) 5Hyl-COL1A1 [extracellular region] (R-HSA-2089974) 3x4Hyp-3Hyp-COL1A1 [extracellular region] (R-HSA-2089989)	0.488	2
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.488	2
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.488	2
UniProt:Q9H1Y0 ATG5	3	GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010) ATG5 [phagocytic vesicle membrane] (R-HSA-5205636)	0.488	2
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.488	2