Reactome | MAPK7 [cytosol]

MAPK7 [cytosol]

Stable Identifier

R-HSA-198754

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ERK5, Mitogen-activated protein kinase 7, MK07_HUMAN

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERK5 (Homo sapiens)
        
        ERK5 is activated (Homo sapiens)
        
        MAPK7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13164 MAPK7

Gene Names

MAPK7, BMK1, ERK5, PRKM7

Chain

initiator methionine:, chain:2-816

Reference Genes

BioGPS Gene:5598 MAPK7

COSMIC (genes):MAPK7 MAPK7

CTD Gene:5598 MAPK7

dbSNP Gene:5598 MAPK7

ENSEMBL:ENSG00000166484 MAPK7

HGNC:6880 MAPK7

KEGG:hsa:5598 MAPK7

Monarch:5598 MAPK7

NCBI Gene:5598 MAPK7

OMIM:602521 MAPK7

UCSC:Q13164 MAPK7

Reference Transcript

Other Identifiers

11744231_a_at

16832071

207292_PM_s_at

207292_s_at

35617_PM_at

35617_at

3713873

3713875

3713876

3713877

3713878

3713879

3713880

3713881

3713882

3713883

3713884

3713885

3713886

3713887

3713888

3713889

3713890

3713891

5598

8005576

A_14_P117950

A_14_P122654

A_14_P139059

A_23_P100704

GE81188

GO:0000165

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0004857

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0007165

GO:0007189

GO:0016605

GO:0016740

GO:0030154

GO:0033173

GO:0034115

GO:0034392

GO:0035556

GO:0043066

GO:0043226

GO:0045765

GO:0045944

GO:0050728

GO:0051019

GO:0051247

GO:0060761

GO:0070301

GO:0070885

GO:0071363

GO:0071499

GO:0071560

GO:0098772

GO:0106310

GO:0140096

GO:1902176

GO:2000352

GO:2001240

HMNXSV003037364

ILMN_1709623

ILMN_2244699

ILMN_2339655

PH_hs_0022673

TC17000237.hg

U29725_at

g4506092_3p_s_at

Participates

as a member of

RET interactors [cytosol] (Homo sapiens)

as an input of

ERK5 is activated (Homo sapiens)

Other forms of this molecule

p-T218,Y221-MAPK7 [nucleoplasm]

p-T218,Y221-MAPK7 [cytosol]

MAPK7 [nucleoplasm]

Inferred To

MAPK7 [cytosol] (Bos taurus)

MAPK7 [cytosol] (Canis familiaris)

MAPK7 [cytosol] (Gallus gallus)

MAPK7 [cytosol] (Mus musculus)

MAPK7 [cytosol] (Rattus norvegicus)

MAPK7 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_011522259.1, NP_620601.1, NP_620603.2, NP_620602.2, NP_002740.2

ZINC - World Drugs

MK07_HUMAN

Guide to Pharmacology - Targets

2093

OpenTargets

ENSG00000166484

ENSEMBL

ENSP00000311005, ENSP00000378968, ENST00000395602, ENST00000299612, ENST00000308406, ENSP00000378966, ENSP00000299612, ENST00000395604

ZINC - FDA approved

MK07_HUMAN

ZINC - Substances

MK07_HUMAN

ZINC - Biogenic

MK07_HUMAN

ZINC target

Q13164

PRO

Q13164

GlyGen

Q13164

PDB

5BYY, 5O7I, 4ZSG, 5BYZ, 4B99, 6HKM, 6HKN, 4ZSJ, 7PUS, 4ZSL, 2Q8Y, 4IC7, 4IC8

ZINC - Investigational

MK07_HUMAN

HPA

ENSG00000166484-MAPK7

Pharos - Targets

Q13164

ZINC - Predictions - Purchasable

MK07_HUMAN

HMDB Protein

HMDBP01203

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13163 MAP2K5	1	MAP2K5 [cytosol] (R-HSA-198722)	0.863	8
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.643	4
UniProt:P61758 VBP1	1	VBP1 [cytosol] (R-HSA-379543)	0.643	4
UniProt:O15212 PFDN6	1	PFDN6 [cytosol] (R-HSA-379547)	0.643	4
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.643	4
UniProt:Q9NQP4 PFDN4	1	PFDN4 [cytosol] (R-HSA-379542)	0.643	4
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.643	4
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.571	6
UniProt:Q12055	1	AK6 [nucleoplasm] (R-SCE-6788786)	0.556	3
UniProt:Q16204 CCDC6			0.556	3
UniProt:P53286 BTN2			0.556	3
UniProt:Q12156	3	AIM7 [ficolin-1-rich granule lumen] (R-SCE-6801480) AIM7 [extracellular region] (R-SCE-6806473) AIM7 [secretory granule lumen] (R-SCE-6801500)	0.556	3
UniProt:Q5TZN3 Q5TZN3			0.556	3
UniProt:O00762 UBE2C	4	UBE2C [cytosol] (R-HSA-174244) UBE2C [nucleoplasm] (R-HSA-174188) Ub-C114-UBE2C [nucleoplasm] (R-HSA-8864178) Ub-C114-UBE2C [cytosol] (R-HSA-8864184)	0.556	3
UniProt:P17029 ZKSCAN1	1	ZKSCAN1 [nucleoplasm] (R-HSA-975013)	0.556	3
UniProt:Q02078-6 MEF2A			0.556	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.499	3