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CKS1B [nucleoplasm]
Stable Identifier
R-HSA-187533
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cks1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CKS1B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61024 CKS1B
Gene Names
CKS1B, CKS1, PNAS-143, PNAS-16
Chain
initiator methionine:1, chain:2-79
Reference Genes
BioGPS Gene:1163 CKS1B
COSMIC (genes):CKS1B CKS1B
CTD Gene:1163 CKS1B
dbSNP Gene:1163 CKS1B
ENSEMBL:ENSG00000173207 CKS1B
HGNC:19083 CKS1B
KEGG Gene (Homo sapiens):1163 CKS1B
Monarch:1163 CKS1B
NCBI Gene:1163 CKS1B
OMIM:116900 CKS1B
Reference Transcript
RefSeq:NM_001826.2 CKS1B
Other Identifiers
1163
11716092_x_at
11754031_s_at
11758200_x_at
201897_PM_s_at
201897_s_at
2360453
2360454
2360460
2360462
2360463
2360464
2360465
2859242
2859243
3240804
37347_at
7905826
7926896
8112327
A_23_P45917
GE59801
GE86719
GO:0000278
GO:0000307
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006355
GO:0006464
GO:0007049
GO:0007346
GO:0008150
GO:0008283
GO:0009058
GO:0016301
GO:0016310
GO:0016538
GO:0019005
GO:0019899
GO:0019901
GO:0030234
GO:0032182
GO:0032991
GO:0034641
GO:0042393
GO:0043130
GO:0043226
GO:0044772
GO:0045737
GO:0050790
GO:0051301
GO:0061575
HMNXSV003051939
ILMN_2041046
TC01004760.hg
X54941_at
g4502856_3p_a_at
Participates
as an input of
Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
as a component of
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Inferred To
Cks1b [nucleoplasm]
(Mus musculus)
Cks1b [nucleoplasm]
(Rattus norvegicus)
cks1b [nucleoplasm]
(Danio rerio)
CKS1B [nucleoplasm]
(Bos taurus)
CKS1B [nucleoplasm]
(Canis familiaris)
CKS1B [nucleoplasm]
(Gallus gallus)
CKS1B [nucleoplasm]
(Sus scrofa)
CKS1B [nucleoplasm]
(Xenopus tropicalis)
cks-1 [nucleoplasm]
(Caenorhabditis elegans)
Cks30A [nucleoplasm]
(Drosophila melanogaster)
cks1 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001817.1
OpenTargets
ENSG00000173207
HPA
ENSG00000173207-CKS1B
GeneCards
P61024
Ensembl
ENST00000308987
,
ENSG00000173207
,
ENSP00000311083
PRO
P61024
Pharos - Targets
P61024
PDB
7NJ0
,
7B5R
,
1DKS
,
2ASS
,
1BUH
,
7B5L
,
4YC6
,
7B5M
,
2AST
,
1DKT
Interactors (58)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.941
21
UniProt:P06493 CDK1
10
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.894
10
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.816
7
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.781
7
UniProt:P46527 CDKN1B
8
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
CDKN1B [cytosol]
(R-HSA-198622)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.743
4
UniProt:Q00526 CDK3
0.742
5
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.723
4
UniProt:P50221 MEOX1
0.718
6
UniProt:Q9HAT0 ROPN1
1
ROPN1 [cytosol]
(R-HSA-5667048)
0.718
6
UniProt:Q9UH03 SEPT3
0.718
6
UniProt:Q03989 ARI5A
0.696
5
UniProt:A6NLX3 SPDE4
0.666
6
UniProt:P0CI25 TRI49
0.666
4
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.643
3
UniProt:P11440 Cdk1
10
phospho-Cdk1 [nucleoplasm]
(R-MMU-170066)
phospho-Cdk1 [nucleoplasm]
(R-MMU-170074)
phospho-Cdk1 [cytosol]
(R-MMU-157415)
phospho-Cdk1 [cytosol]
(R-MMU-170071)
Cdk1 [cytosol]
(R-MMU-170075)
phospho-Cdk1 [cytosol]
(R-MMU-170064)
phospho-Cdk1 [nucleoplasm]
(R-MMU-170045)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-Cdk1 [nucleoplasm]
(R-MMU-170078)
Cdk1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.623
4
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.564
3
UniProt:Q9Y250 LZTS1
0.556
3
UniProt:Q9UPY6-2 WASF3
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q5T749 KPRP
0.556
3
UniProt:P0CI26 TR49C
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:P15884-3 TCF4
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
UniProt:Q9UBR4-2 LHX3
0.556
3
UniProt:Q9UHV2 SRTD1
0.556
3
UniProt:Q13422 IKZF1
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q02548 PAX5
1
PAX5 [nucleoplasm]
(R-HSA-158583)
0.556
3
UniProt:Q13285 NR5A1
3
NR5A1 [nucleoplasm]
(R-HSA-452955)
polySUMO2-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546383)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546382)
0.556
3
UniProt:Q16560-2 SNRNP35
0.556
3
UniProt:Q8NA61-2 CBY2
0.556
3
UniProt:Q86YW9 MD12L
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:Q96C00 ZBTB9
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q96HB5 CC120
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q5HYN5 CT451
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q14142 TRIM14
1
TRIM14 [cytosol]
(R-HSA-5624345)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:Q14140 SRTD2
0.556
3
UniProt:G2XKQ0 SUMO5
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q96KQ4 PPP1R13B
1
PPP1R13B [nucleoplasm]
(R-HSA-6799775)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q8NA61 CBY2
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q99081-3 TCF12
0.556
3
UniProt:Q13422-7 IKZF1
0.556
3
UniProt:Q9UHG0 DCDC2
0.556
3
UniProt:O14627 CDX4
0.556
3
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.527
4
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.527
2
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.527
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.527
2
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