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ACO1 [cytosol]
Stable Identifier
R-HSA-5690899
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cytoplasmic aconitate hydratase, ACOC_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
NADPH regeneration (Homo sapiens)
ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)
ACO1:4Fe-4S [cytosol] (Homo sapiens)
ACO1 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
ACO1 binds 4Fe-4S (Homo sapiens)
ACO1 [cytosol] (Homo sapiens)
ACO1:4Fe-4S [cytosol] (Homo sapiens)
ACO1 [cytosol] (Homo sapiens)
ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)
ACO1, IREB2 [cytosol] (Homo sapiens)
ACO1 [cytosol] (Homo sapiens)
ACO1, IREB2:TFRC, ALAD, FTL, FTH1 mRNAs [cytosol] (Homo sapiens)
ACO1, IREB2 [cytosol] (Homo sapiens)
ACO1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21399 ACO1
Gene Names
ACO1, IREB1
Chain
chain:1-889
Reference Genes
BioGPS Gene:48 ACO1
COSMIC (genes):ACO1 ACO1
CTD Gene:48 ACO1
dbSNP Gene:48 ACO1
ENSEMBL:ENSG00000122729 ACO1
HGNC:117 ACO1
KEGG:hsa:48 ACO1
Monarch:48 ACO1
NCBI Gene:48 ACO1
OMIM:100880 ACO1
UCSC:P21399 ACO1
Reference Transcript
RefSeq:NM_001278352.2 ACO1
RefSeq:XM_005251476.1 ACO1
RefSeq:NM_001362840.2 ACO1
RefSeq:NM_002197.3 ACO1
RefSeq:XM_011517888.1 ACO1
RefSeq:XM_054363007.1 ACO1
Other Identifiers
11743758_a_at
11755357_s_at
11764092_at
17084184
207071_PM_s_at
207071_s_at
237622_PM_at
237622_at
3166486
3166490
3166492
3166493
3166494
3166495
3166499
3166501
3166502
3166503
3166506
3166507
3166509
3166510
3166512
3166514
3166515
3166516
3166518
3166519
3166522
3166525
3166526
3166527
3166528
3166529
3166530
3166531
3166536
3166538
3166540
3166541
3166543
3166545
3166547
40077_at
48
58072_at
8154733
A_14_P136455
A_23_P9415
A_23_P9416
GE528028
GE60348
GE865229
GO:0000900
GO:0003723
GO:0003824
GO:0003994
GO:0005515
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005829
GO:0006099
GO:0006101
GO:0006417
GO:0006879
GO:0009791
GO:0010040
GO:0010468
GO:0016829
GO:0017148
GO:0022600
GO:0030350
GO:0043226
GO:0045182
GO:0046872
GO:0050892
GO:0051536
GO:0051538
GO:0051539
GO:0070062
HMNXSV003007327
Hs.104091.0.A1_3p_at
ILMN_1750800
PH_hs_0023784
TC09000128.hg
Z11559_at
g8659554_3p_a_at
Participates
as a member of
ACO1, IREB2 [cytosol] (Homo sapiens)
as a component of
ACO1:4Fe-4S [cytosol] (Homo sapiens)
as an input of
ACO1 binds 4Fe-4S (Homo sapiens)
Inferred To
Irp-1B [cytosol]
(Drosophila melanogaster)
ACO1 [cytosol]
(Bos taurus)
ACO1 [cytosol]
(Canis familiaris)
ACO1 [cytosol]
(Gallus gallus)
ACO1 [cytosol]
(Plasmodium falciparum)
ACO1 [cytosol]
(Sus scrofa)
aco1 [cytosol]
(Danio rerio)
aco1 [cytosol]
(Dictyostelium discoideum)
aco1 [cytosol]
(Xenopus tropicalis)
Aco1 [cytosol]
(Mus musculus)
Aco1 [cytosol]
(Rattus norvegicus)
aco-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001265281.1
,
XP_005251533.1
,
NP_002188.1
,
XP_054218982.1
,
NP_001349769.1
,
XP_011516190.1
ENSEMBL
ENST00000541043
,
ENSP00000438733
,
ENSG00000122729
,
ENST00000309951
,
ENST00000379923
,
ENSP00000309477
,
ENSP00000369255
OpenTargets
ENSG00000122729
GeneCards
ACO1
HPA
ENSG00000122729-ACO1
PRO
P21399
Pharos - Targets
P21399
GlyGen
P21399
HMDB Protein
HMDBP00726
PDB
2B3Y
,
2B3X
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.553
4
UniProt:Q13326 SGCG
2
SGCG [endoplasmic reticulum membrane]
(R-HSA-9913189)
SGCG [plasma membrane]
(R-HSA-9630716)
0.454
2
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