Reactome | ACO1 [cytosol]

ACO1 [cytosol]

Stable Identifier

R-HSA-5690899

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cytoplasmic aconitate hydratase, ACOC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P21399 ACO1

Gene Names

ACO1, IREB1

Chain

chain:1-889

Reference Genes

BioGPS Gene:48 ACO1

COSMIC (genes):ACO1 ACO1

CTD Gene:48 ACO1

dbSNP Gene:48 ACO1

ENSEMBL:ENSG00000122729 ACO1

HGNC:117 ACO1

KEGG:hsa:48 ACO1

Monarch:48 ACO1

NCBI Gene:48 ACO1

OMIM:100880 ACO1

UCSC:P21399 ACO1

Reference Transcript

Other Identifiers

11743758_a_at

11755357_s_at

11764092_at

17084184

207071_PM_s_at

207071_s_at

237622_PM_at

237622_at

3166486

3166490

3166492

3166493

3166494

3166495

3166499

3166501

3166502

3166503

3166506

3166507

3166509

3166510

3166512

3166514

3166515

3166516

3166518

3166519

3166522

3166525

3166526

3166527

3166528

3166529

3166530

3166531

3166536

3166538

3166540

3166541

3166543

3166545

3166547

40077_at

58072_at

8154733

A_14_P136455

A_23_P9415

A_23_P9416

GE528028

GE60348

GE865229

GO:0000900

GO:0003723

GO:0003824

GO:0003994

GO:0005515

GO:0005737

GO:0005739

GO:0005783

GO:0005794

GO:0005829

GO:0006099

GO:0006101

GO:0006417

GO:0006879

GO:0009791

GO:0010040

GO:0010468

GO:0016829

GO:0017148

GO:0022600

GO:0030350

GO:0043226

GO:0045182

GO:0046872

GO:0050892

GO:0051536

GO:0051538

GO:0051539

GO:0070062

HMNXSV003007327

Hs.104091.0.A1_3p_at

ILMN_1750800

PH_hs_0023784

TC09000128.hg

Z11559_at

g8659554_3p_a_at

Participates

as a member of

ACO1, IREB2 [cytosol] (Homo sapiens)

as a component of

ACO1:4Fe-4S [cytosol] (Homo sapiens)

as an input of

ACO1 binds 4Fe-4S (Homo sapiens)

Inferred To

Irp-1B [cytosol] (Drosophila melanogaster)

ACO1 [cytosol] (Bos taurus)

ACO1 [cytosol] (Canis familiaris)

ACO1 [cytosol] (Gallus gallus)

ACO1 [cytosol] (Plasmodium falciparum)

ACO1 [cytosol] (Sus scrofa)

aco1 [cytosol] (Danio rerio)

aco1 [cytosol] (Dictyostelium discoideum)

aco1 [cytosol] (Xenopus tropicalis)

Aco1 [cytosol] (Mus musculus)

Aco1 [cytosol] (Rattus norvegicus)

aco-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001265281.1, XP_005251533.1, NP_002188.1, XP_054218982.1, NP_001349769.1, XP_011516190.1

ENSEMBL

ENST00000541043, ENSP00000438733, ENSG00000122729, ENST00000309951, ENST00000379923, ENSP00000309477, ENSP00000369255

OpenTargets

ENSG00000122729

GeneCards

ACO1

HPA

ENSG00000122729-ACO1

PRO

P21399

Pharos - Targets

P21399

GlyGen

P21399

HMDB Protein

HMDBP00726

PDB

2B3Y, 2B3X

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.553	4
UniProt:Q13326 SGCG	2	SGCG [endoplasmic reticulum membrane] (R-HSA-9913189) SGCG [plasma membrane] (R-HSA-9630716)	0.454	2

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