Reactome | p-T180,Y182-MAPK11 [nucleoplasm]

p-T180,Y182-MAPK11 [nucleoplasm]

Stable Identifier

R-HSA-198741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-T180,Y182-MAP kinase p38 beta, p-MAPK11-1

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        MAPKAPK5 phosphorylates TP53 (Homo sapiens)
        
        phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
        
        p-T180,Y182-MAPK11 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        p38MAPK phosphorylates MSK1 (Homo sapiens)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
        
        p-T180,Y182-MAPK11 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15759 MAPK11

Gene Names

MAPK11, PRKM11, SAPK2, SAPK2B

Chain

chain:1-364

Reference Genes

BioGPS Gene:5600 MAPK11

COSMIC (genes):MAPK11 MAPK11

CTD Gene:5600 MAPK11

dbSNP Gene:5600 MAPK11

ENSEMBL:ENSG00000185386 MAPK11

ENSEMBL_homo_sapiens_GENE:ENSG00000185386.15 MAPK11

HGNC:6873 MAPK11

KEGG Gene (Homo sapiens):5600 MAPK11

Monarch:5600 MAPK11

NCBI Gene:5600 MAPK11

OMIM:602898 MAPK11

UCSC:Q15759 MAPK11

Reference Transcript

RefSeq:NM_002751.6 MAPK11

Other Identifiers

1010_at

11730965_a_at

11730966_at

16936432

206040_PM_s_at

206040_s_at

211499_PM_s_at

211499_s_at

211500_PM_at

211500_at

3965783

3965785

3965786

3965787

3965788

3965789

3965790

3965791

3965793

3965795

3965797

3965798

3965800

3965801

3965802

3965803

3965804

3965805

3965806

3965807

3965808

40033_at

5600

8076978

A_23_P502274

A_33_P3409508

A_33_P3409513

GE88364

GO:0000165

GO:0000166

GO:0001649

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0010628

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0031098

GO:0032735

GO:0033554

GO:0035556

GO:0036211

GO:0038066

GO:0043226

GO:0048856

GO:0051149

GO:0051403

GO:0060038

GO:0060043

GO:0060044

GO:0060348

GO:0071347

GO:0071493

GO:0090398

GO:0098586

GO:0106310

GO:0140096

HMNXSV003058003

ILMN_1724715

ILMN_1735361

PH_hs_0003700

TC22000910.hg

U53442_at

g1469305_3p_at

g1469305_3p_x_at

g2316011_3p_a_at

g4506082_3p_a_at

Participates

as a member of

Other forms of this molecule

MAPK11 [nucleoplasm]

MAPK11 [cytosol]

p-T180,Y182-MAPK11 [cytosol]

Inferred To

p-T180,Y182-Mapk11 [nucleoplasm] (Mus musculus)

phospho-Mapk11 [nucleoplasm] (Rattus norvegicus)

phospho-MAPK11 [nucleoplasm] (Canis familiaris)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Bos taurus)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Danio rerio)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Sus scrofa)

phospho-p-T180,Y182-MAPK11 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 180

Coordinate

180

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 182

Coordinate

182

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002742.3

ZINC - World Drugs

MK11_HUMAN

Guide to Pharmacology - Targets

1500

OpenTargets

ENSG00000185386

ZINC - FDA approved

MK11_HUMAN

ZINC - Substances

MK11_HUMAN

ZINC target

Q15759

PRO

Q15759

PDB

3GP0, 3GC9, 8YGW, 3GC8

ZINC - Investigational

MK11_HUMAN

IntEnz

2.7.11.24

HPA

ENSG00000185386-MAPK11

GeneCards

Q15759

Ensembl

ENST00000330651, ENSG00000185386, ENSP00000379113, ENSP00000333685, ENST00000395764

Pharos - Targets

Q15759

ZINC - Predictions - Purchasable

MK11_HUMAN

HMDB Protein

HMDBP01336

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.643	4
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.547	2

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