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PREX2 [cytosol]
Stable Identifier
R-HSA-8850949
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein, P-Rex2, PtdIns(3,4,5)-dependent Rac exchanger 2, DEPDC2, DEP domain-containing protein 2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
PREX2 binds PTEN and inhibits it (Homo sapiens)
PREX2 [cytosol] (Homo sapiens)
PREX2:PTEN,p-3S,2T-PTEN [cytosol] (Homo sapiens)
PREX2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
PREX2 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
PREX2 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
PREX2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q70Z35 PREX2
Gene Names
PREX2, DEPDC2
Chain
chain:1-1606
Reference Genes
BioGPS Gene:80243 PREX2
COSMIC (genes):PREX2 PREX2
CTD Gene:80243 PREX2
dbSNP Gene:80243 PREX2
ENSEMBL:ENSG00000046889 PREX2
ENSEMBL_homo_sapiens_GENE:ENSG00000046889.19 PREX2
HGNC:22950 PREX2
KEGG Gene (Homo sapiens):80243 PREX2
Monarch:80243 PREX2
NCBI Gene:80243 PREX2
OMIM:612139 PREX2
UCSC:Q70Z35 PREX2
Reference Transcript
RefSeq:NM_024870.3 PREX2
RefSeq:NM_025170.5 PREX2
Other Identifiers
11738148_a_at
11740690_at
11750626_a_at
17069728
228692_PM_at
228692_at
233408_PM_at
233408_at
3102097
3102098
3102109
3102112
3102113
3102114
3102117
3102118
3102119
3102120
3102122
3102123
3102124
3102125
3102127
3102128
3102129
3102130
3102131
3102132
3102133
3102137
3102140
3102141
3102143
3102147
3102148
3102149
3102151
3102152
3102153
3102154
3102155
3102156
3102159
3102162
3102163
3102165
3102166
3102170
3102174
3102175
3102181
3102188
3102191
3102192
3102193
3102194
3102195
3102196
3298066
47972_r_at
80243
8146794
A_14_P110140
A_14_P111086
A_14_P116881
A_14_P130275
A_32_P59648
A_33_P3394995
GE83116
GE88771
GO:0005085
GO:0005096
GO:0005515
GO:0005829
GO:0005886
GO:0007186
GO:0008344
GO:0023051
GO:0023052
GO:0030154
GO:0035556
GO:0043491
GO:0048813
GO:0048856
GO:0051056
GO:0098772
HMNXSV003009826
Hs.169943.0.S1_3p_at
Hs.296730.1.S1_3p_at
ILMN_1661806
ILMN_1677652
ILMN_2369179
PH_hs_0010138
PH_hs_0031704
TC08000452.hg
TC08001960.hg
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
as a member of
RAC1 GEFs [cytosol] (Homo sapiens)
as a component of
PREX2:PTEN,p-3S,2T-PTEN [cytosol] (Homo sapiens)
as an input of
PREX2 binds PTEN and inhibits it (Homo sapiens)
Inferred To
PREX2 [cytosol]
(Bos taurus)
PREX2 [cytosol]
(Canis familiaris)
PREX2 [cytosol]
(Gallus gallus)
PREX2 [cytosol]
(Sus scrofa)
Prex2 [cytosol]
(Mus musculus)
Prex2 [cytosol]
(Rattus norvegicus)
prex2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_079146.2
,
NP_079446.3
OpenTargets
ENSG00000046889
GeneCards
Q70Z35
HPA
ENSG00000046889-PREX2
Ensembl
ENST00000288368
,
ENSG00000046889
,
ENSP00000288368
PRO
Q70Z35
Pharos - Targets
Q70Z35
HMDB Protein
HMDBP08343
PDB
6BNM
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