Reactome | CNKSR1 [cytosol]

CNKSR1 [cytosol]

Stable Identifier

R-HSA-5672629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q969H4 CNKSR1

Gene Names

CNKSR1, CNK1

Chain

chain:1-720

Reference Genes

BioGPS Gene:10256 CNKSR1

COSMIC (genes):CNKSR1 CNKSR1

CTD Gene:10256 CNKSR1

dbSNP Gene:10256 CNKSR1

ENSEMBL:ENSG00000142675 CNKSR1

HGNC:19700 CNKSR1

KEGG:hsa:10256 CNKSR1

Monarch:10256 CNKSR1

NCBI Gene:10256 CNKSR1

OMIM:603272 CNKSR1

UCSC:Q969H4 CNKSR1

Reference Transcript

Other Identifiers

10256

11757207_at

16661071

204740_PM_at

204740_at

2326331

2326332

2326333

2326334

2326335

2326336

2326337

2326338

2326339

2326340

2326341

2326342

2326343

2326344

2326345

2326346

2326347

2326348

2326349

2326350

2326351

2326352

2326353

2326354

2326355

2326356

2326357

2326358

2326359

2326360

2326361

2326362

2326363

2326365

2326366

2326367

38221_at

7899101

A_14_P103606

A_14_P114390

A_23_P23341

A_33_P3386242

GE54791

GO:0003824

GO:0005515

GO:0005737

GO:0005886

GO:0005911

GO:0005938

GO:0007169

GO:0016020

GO:0016301

GO:0016740

GO:0030674

GO:0060090

HMNXSV003009956

ILMN_1718813

PH_hs_0001500

TC01000336.hg

TC01004255.hg

g5453622_3p_at

Participates

as a candidate of

RAF/MAPK scaffolds [cytosol] (Homo sapiens)

Inferred To

cnksr1 [cytosol] (Xenopus tropicalis)

Cnksr1 [cytosol] (Mus musculus)

Cnksr1 [cytosol] (Rattus norvegicus)

cnk [cytosol] (Drosophila melanogaster)

cnk-1 [cytosol] (Caenorhabditis elegans)

CNKSR1 [cytosol] (Bos taurus)

CNKSR1 [cytosol] (Canis familiaris)

CNKSR1 [cytosol] (Gallus gallus)

CNKSR1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001284577.1, NP_006305.2, NP_001284576.1

ENSEMBL

ENST00000361530, ENSG00000142675, ENSP00000363371, ENST00000374253, ENSP00000354609

OpenTargets

ENSG00000142675

GeneCards

CNKSR1

HPA

ENSG00000142675-CNKSR1

PRO

Q969H4

Pharos - Targets

Q969H4

PDB

1WWV

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.718	6
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.527	2
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971)	0.471	4

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