p-G464E BRAF

Stable Identifier
R-HSA-8936645
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
B-RAF
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15035987 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Wan, PT, Garnett, MJ, Roe, SM, Lee, S, Niculescu-Duvaz, D, Good, VM, Jones, CM, Marshall, CJ, Springer, CJ, Barford, D, Marais, R

Cell 2004
12068308 Mutations of the BRAF gene in human cancer

Davies, H, Bignell, GR, Cox, C, Stephens, P, Edkins, S, Clegg, S, Teague, J, Woffendin, H, Garnett, MJ, Bottomley, W, Davis, N, Dicks, E, Ewing, R, Floyd, Y, Gray, K, Hall, S, Hawes, R, Hughes, J, Kosmidou, V, Menzies, A, Mould, C, Parker, A, Stevens, C, Watt, S, Hooper, S, Wilson, R, Jayatilake, H, Gusterson, BA, Cooper, C, Shipley, J, Hargrave, D, Pritchard-Jones, K, Maitland, N, Chenevix-Trench, G, Riggins, GJ, Bigner, DD, Palmieri, G, Cossu, A, Flanagan, A, Nicholson, A, Ho, JW, Leung, SY, Yuen, ST, Weber, BL, Seigler, HF, Darrow, TL, Paterson, H, Marais, R, Marshall, CJ, Wooster, R, Stratton, MR, Futreal, PA

Nature 2002
External Reference Information
External Reference
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Transcript
Other Identifiers
11732491_s_at
1328
1654_at
17063631
1UWH
1UWJ
206044_s_at
2FB8
2L05
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076385
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3982166
3982173
3C4C
3D4Q
3IDP
3II5
3NY5
3OG7
3PPJ
3PPK
3PRF
3PRI
3PSB
3PSD
3Q4C
3Q96
3SKC
3TV4
3TV6
40306_at
4552
4CQE
4DBN
4E26
4E4X
4EHE
4EHG
4FC0
4FK3
4G9C
4G9R
4H58
4JVG
4KSP
4KSQ
4MBJ
4MNE
4MNF
4PP7
4R5Y
4RZV
4RZW
4WO5
4XV1
4XV2
4XV3
4XV9
4YHT
5C9C
5CSW
5CSX
5CT7
5FD2
5HI2
5HID
5HIE
5ITA
5J17
5J18
5J2R
5JRQ
5JSM
5JT2
5VAL
5VAM
5VYK
673
6B8U
6CAD
71048
8143417
A_23_P42935
AAA35609
AAA96495
AAD15551
AAD43193
AAI01758
AAI12080
AC006344
AC006347
ACD11489
AM989472
AM989473
AM989474
AM989475
AM989476
AM989477
BC101757
BC112079
BRAF
BRAF-201
CAA46301
CAB004552
CAQ43111
CAQ43112
CAQ43113
CAQ43114
CAQ43115
CAQ43116
CH236950
EAL24023
ENSG00000157764
ENSP00000288602
ENSP00000419060
ENSP00000493543
ENST00000288602
ENST00000496384
ENST00000644905
ENST00000646891
EntrezGene:673
EU600171
g4757867_3p_a_at
GE58163
GO:0000165
GO:0000166
GO:0000186
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0004871
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0008150
GO:0008219
GO:0009887
GO:0009968
GO:0010628
GO:0010828
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0030154
GO:0031434
GO:0033138
GO:0035556
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0046872
GO:0048856
GO:0055085
GO:0070374
GO:0070413
GO:0071277
GO:0090150
HGNC:1097
HPA001328
HPA071048
ILMN_1652472
IPR000719
IPR001245
IPR002219
IPR003116
IPR008271
IPR011009
IPR017441
IPR020454
IPR029071
LRG_299
LRG_299t1
M21001
M95712
M95712_at
MIM:115150
MIM:163950
MIM:164757
MIM:211980
MIM:613706
MIM:613707
PF00130
PF02196
PF07714
PH_hs_0027912
PR00008
SM00109
SM00220
SM00455
TC07001927.hg
uc003vwc.5
UPI000D18C53F
X65187
XR_001744857
Participant Of
Other forms of this molecule
Modified Residues
Name
glycine 464 replaced with L-glutamic acid
Coordinate
464
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
A protein modification that effectively removes or replaces an glycine.
Name
O-phospho-L-serine at 445
Coordinate
445
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
melanoma 1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Cross References
RefSeq
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Metabolites
COSMIC
GeneCards
BRENDA (Homo sapiens)
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q02750 MAP2K1  7 0.976 58
 UniProt:P04049 RAF1  11 0.957 55
 UniProt:P15056 BRAF  34 0.907 13
 UniProt:P63104 YWHAZ  2 0.822 6
 UniProt:P31946 YWHAB  1 0.763 5
 UniProt:P01112 HRAS  8 0.719 4
 UniProt:P61981 YWHAG  1 0.688 3
 UniProt:P27348 YWHAQ  1 0.688 3
 UniProt:P10398 ARAF  4 0.669 3
 UniProt:P36507 MAP2K2  5 0.669 6
 UniProt:Q13233 MAP3K1  2 0.609 2
 UniProt:P01111 NRAS  8 0.591 3
 UniProt:P08238 HSP90AB1  5 0.564 2
 UniProt:P46940 IQGAP1  3 0.544 4
 UniProt:Q61097  5 0.499 3
 UniProt:Q99N57  11 0.499 3