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CDKN2B [cytosol]
Stable Identifier
R-HSA-182586
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
P15-INK4B, Cyclin-dependent kinase 4 inhibitor B, MTS2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
Formation of CDK4/6:CCND complexes (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
INK4 [cytosol] (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)
CDKN2B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42772 CDKN2B
Gene Names
CDKN2B, MTS2
Chain
chain:1-138
Reference Genes
BioGPS Gene:1030 CDKN2B
COSMIC (genes):CDKN2B CDKN2B
CTD Gene:1030 CDKN2B
dbSNP Gene:1030 CDKN2B
ENSEMBL:ENSG00000147883 CDKN2B
ENSEMBL_homo_sapiens_GENE:ENSG00000147883.12 CDKN2B
HGNC:1788 CDKN2B
KEGG Gene (Homo sapiens):1030 CDKN2B
Monarch:1030 CDKN2B
NCBI Gene:1030 CDKN2B
OMIM:600431 CDKN2B
UCSC:P42772 CDKN2B
Reference Transcript
RefSeq:NM_078487.2 CDKN2B
RefSeq:NM_004936.3 CDKN2B
Other Identifiers
1030
11726507_a_at
11726508_a_at
11736163_a_at
1607_at
17092901
207530_PM_s_at
207530_s_at
236313_PM_at
236313_at
3201459
3201460
3201489
3201490
3201491
3201494
3201495
3201496
3201497
3201498
3201499
3201500
3201501
34624_at
54310_at
73132_r_at
75652_at
8160452
A_23_P216812
A_24_P360674
GE81459
GO:0000079
GO:0000278
GO:0001889
GO:0002376
GO:0004861
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0007049
GO:0008285
GO:0014070
GO:0019901
GO:0023052
GO:0030154
GO:0030219
GO:0030511
GO:0030858
GO:0031668
GO:0031670
GO:0034097
GO:0036211
GO:0042326
GO:0043226
GO:0048536
GO:0048856
GO:0050680
GO:0060253
GO:0070316
GO:0071560
GO:0090398
GO:0098772
GO:1902807
GO:2000045
GO:2000134
HMNXSV003044699
Hs.44565.0.A1_3p_at
ILMN_1670111
ILMN_1723198
ILMN_2376723
L36844_at
PH_hs_0004184
TC09000965.hg
g11386206_3p_a_at
Participates
as an output of
Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)
SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)
as a member of
INK4 [cytosol] (Homo sapiens)
Inferred To
Cdkn2b [cytosol]
(Mus musculus)
Cdkn2b [cytosol]
(Rattus norvegicus)
CDKN2B [cytosol]
(Bos taurus)
CDKN2B [cytosol]
(Canis familiaris)
CDKN2B [cytosol]
(Gallus gallus)
CDKN2B [cytosol]
(Sus scrofa)
cdkn2b [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004927.2
,
NP_511042.1
OpenTargets
ENSG00000147883
GeneCards
P42772
HPA
ENSG00000147883-CDKN2B
Ensembl
ENSP00000276925
,
ENSG00000147883
,
ENST00000276925
,
ENSP00000369487
,
ENST00000380142
PRO
P42772
Pharos - Targets
P42772
Orphanet
20850
HMDB Protein
HMDBP14516
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.968
22
UniProt:Q00534 CDK6
3
CDK6 [cytosol]
(R-HSA-68336)
CDK6 [nucleoplasm]
(R-HSA-141283)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.919
19
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.735
7
UniProt:P43364 MAGAB
0.666
4
UniProt:Q00537 CDK17
0.556
3
UniProt:Q53H96 PYCRL
1
PYCRL [cytosol]
(R-HSA-6783934)
0.556
3
UniProt:Q9BVN2 RUSC1
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:Q6P9H4 CNKR3
0.556
3
UniProt:Q9NZD8 SPG21
0.556
6
UniProt:A6ZKI3 RTL8C
0.556
3
UniProt:Q9GZT8 NIF3L
0.556
3
UniProt:Q9UI12 ATP6V1H
2
ATP6V1H [cytosol]
(R-HSA-167578)
ATP6V1H [plasma membrane]
(R-HSA-167602)
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
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