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p-Y1034-JAK1 [cytosol]
Stable Identifier
R-HSA-1112543
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p(Y1034)-JAK1, Tyrosine-protein kinase JAK1, JAK1_HUMAN, Janus kinase 1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23458 JAK1
Gene Names
JAK1, JAK1A, JAK1B
Chain
chain:1-1154
Reference Genes
BioGPS Gene:3716 JAK1
COSMIC (genes):JAK1 JAK1
CTD Gene:3716 JAK1
dbSNP Gene:3716 JAK1
ENSEMBL:ENSG00000162434 JAK1
ENSEMBL:ENSG00000162434.14 JAK1
HGNC:6190 JAK1
KEGG Gene (Homo sapiens):3716 JAK1
Monarch:3716 JAK1
NCBI Gene:3716 JAK1
OMIM:147795 JAK1
UCSC:P23458 JAK1
Reference Transcript
RefSeq:NM_001321852.1 JAK1
RefSeq:NM_001320923.1 JAK1
RefSeq:NM_001321854.1 JAK1
RefSeq:NM_002227.3 JAK1
RefSeq:NM_001321853.1 JAK1
RefSeq:NM_001321856.1 JAK1
RefSeq:NM_001321855.1 JAK1
Other Identifiers
11717685_at
11717686_a_at
11717687_a_at
1457_at
1552610_PM_a_at
1552610_a_at
1552611_PM_a_at
1552611_a_at
16688164
16688214
201648_PM_at
201648_at
2416521
2416523
2416524
2416525
2416526
2416528
2416529
2416530
2416531
2416532
2416534
2416535
2416536
2416537
2416541
2416542
2416544
2416545
2416549
2416553
2416556
2416558
2416559
2416561
2416566
2416568
2416569
2416570
2416593
2416594
2416595
2416709
2416711
34877_at
3716
41594_at
7916747
A_21_P0001139
A_24_P410678
A_33_P3784283
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005126
GO:0005131
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006468
GO:0007155
GO:0007259
GO:0007260
GO:0009898
GO:0010033
GO:0010468
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019897
GO:0019903
GO:0023052
GO:0030154
GO:0030155
GO:0031234
GO:0031410
GO:0031625
GO:0031730
GO:0034112
GO:0035556
GO:0035723
GO:0035771
GO:0036211
GO:0038110
GO:0038113
GO:0038154
GO:0038196
GO:0043226
GO:0046677
GO:0046872
GO:0048856
GO:0051239
GO:0060333
GO:0060337
GO:0070102
GO:0072540
GO:0098542
GO:0098586
GO:0098772
GO:0140096
GO:0140537
GO:0150105
GO:1900182
GO:1903672
HMNXSV003011048
HMNXSV003020647
Hs.50651.0.S2_3p_at
Hs2.50651.1.S1_3p_s_at
Hs2.50651.1.S2_3p_s_at
ILMN_1793384
M64174_at
PH_hs_0025462
TC01002741.hg
TC01002747.hg
TC01005542.hg
p232
Participates
as a member of
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y1034,Y1035-JAK1 [cytosol]
JAK1 [endosome]
p-JAK1 [cytosol]
JAK1 [cytosol]
p-Y-JAK1 [cytosol]
Inferred To
phospho-p-Y1034-JAK1 [cytosol]
(Bos taurus)
phospho-p-Y1034-JAK1 [cytosol]
(Canis familiaris)
phospho-p-Y1034-JAK1 [cytosol]
(Danio rerio)
phospho-p-Y1034-JAK1 [cytosol]
(Mus musculus)
phospho-p-Y1034-JAK1 [cytosol]
(Sus scrofa)
phospho-p-Y1034-JAK1 [cytosol]
(Xenopus tropicalis)
phospho-JAK1 [cytosol]
(Gallus gallus)
phospho-Jak1 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1034
Coordinate
1034
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001308782.1
,
NP_001308785.1
,
NP_001308783.1
,
NP_001308784.1
,
NP_001307852.1
,
NP_002218.2
,
NP_001308781.1
ZINC - World Drugs
JAK1_HUMAN
Guide to Pharmacology - Targets
2047
OpenTargets
ENSG00000162434
ZINC - FDA approved
JAK1_HUMAN
ZINC - Substances
JAK1_HUMAN
ZINC - Biogenic
JAK1_HUMAN
ZINC target
P23458
PRO
P23458
PDB
4K6Z
,
4L00
,
6RSD
,
6ELR
,
6SMB
,
4IVC
,
5KHW
,
6RSC
,
6N7D
,
4E4N
,
4IVB
,
6W8L
,
6N79
,
5WO4
,
6SM8
,
6BBU
,
6AAH
,
4E4L
,
4GS0
,
6HZU
,
6C7Y
,
5L04
,
4K77
,
4EI4
,
3EYH
,
5KHX
,
6N7A
,
4L01
,
4IVD
,
6TPF
,
3EYG
,
6DBN
,
5IXD
,
4EHZ
,
6GGH
,
6TPE
,
4E5W
,
6RSB
,
5HX8
,
6N78
,
6RSH
,
5E1E
,
6N7C
,
4FK6
,
5IXI
,
4I5C
,
6N77
,
6RSE
,
6N7B
ZINC - Investigational
JAK1_HUMAN
GeneCards
P23458
HPA
ENSG00000162434-JAK1
Ensembl
ENST00000342505
,
ENSP00000500296
,
ENSG00000162434
,
ENSP00000500485
,
ENSP00000500841
,
ENSP00000343204
,
ENSP00000514291
,
ENST00000699312
,
ENST00000672434
,
ENST00000672179
,
ENST00000672247
,
ENST00000672751
,
ENSP00000500745
,
ENST00000671954
,
ENST00000671929
,
ENST00000699262
,
ENSP00000499884
,
ENSP00000499900
,
ENSP00000514243
Pharos - Targets
P23458
ZINC - Predictions - Purchasable
JAK1_HUMAN
HMDB Protein
HMDBP01309
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42224 STAT1
7
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.757
6
UniProt:P48551 IFNAR2
0.591
3
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.564
2
UniProt:P40189-1 IL6ST
1
p-5Y-IL6ST-1 [plasma membrane]
(R-HSA-1112580)
0.556
3
UniProt:O75886 STAM2
2
Ub-STAM2 [cytosol]
(R-HSA-6782781)
STAM2 [cytosol]
(R-HSA-182965)
0.502
2
UniProt:O60674 JAK2
8
p-Y1007,Y1008-JAK2 [cytosol]
(R-HSA-9005327)
p-JAK2 [cytosol]
(R-HSA-210621)
p-Y813-JAK2 [cytosol]
(R-HSA-997248)
JAK2 V617F [nucleoplasm]
(R-HSA-5211269)
JAK2 [endosome lumen]
(R-HSA-2002372)
p-12Y-JAK2 [cytosol]
(R-HSA-2586516)
p-Y1007-JAK2 [cytosol]
(R-HSA-873799)
JAK2 [cytosol]
(R-HSA-210620)
0.463
4
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